Rush Alzheimer's Disease Research Center

拉什阿尔茨海默病研究中心

• 批准号: 10669633
• 负责人: JULIE A. SCHNEIDER
• 金额: $ 310.65万
• 依托单位: RUSH UNIVERSITY MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-01 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10669633
• 关键词: Aging; Agreement; Alzheimer disease prevention; Alzheimer' s Disease; Alzheimer' s disease related dementia; Autopsy; Biological; Biological Markers; Biometry; Black Populations; Brain; Caregivers; Cell model; Clergy; Clinical; Cohort Studies; Communities; Data; Data Collection; Data Set; Dementia; Disease model; Education; Enrollment; Ethnic Origin; Evaluation; Exercise; Faculty; Funding; Goals; Grant; Heterogeneity; Human; Impaired cognition; Incentives; Infrastructure; Institution; Latino; Latino Population; Leadership; Magnetic Resonance Imaging; Methodology; Molecular Profiling; Nature; Organ Donations; Participant; Pathogenesis; Patients; Persons; Pilot Projects; Positron-Emission Tomography; Prevention; Procedures; Process; Publishing; Recommendation; Reproducibility; Research; Research Personnel; Research Project Grants; Resources; Science; Source; Specimen; Strategic Planning; Structure; Systems Biology; Trust; Work; cohort; collaborative environment; community based research; computer infrastructure; computerized tools; data harmonization; data management; data sharing; distributed data; education research; ethnic minority; follow-up; human data; innovation; multidisciplinary; neuroimaging; neuropathology; new therapeutic target; open data; outreach; patient engagement; predictive modeling; programs; public health priorities; public-private partnership; racial diversity; racial minority; recruit; relational database; religious order study; repository; statistics; student mentoring; virtual

ABSTRACT – OVERALL The overall goal of the proposed Rush ADRC is to create an inter-disciplinary environment that supports innovative research on the causes, treatments, and prevention of AD/ADRD. While the proposed Rush ADRC is for a new grant, it builds on three decades of work by the current Rush ADCC. The Rush ADRC has eight cores and one component, which align with the recommendations of the 2017 NIA strategic plan, including studies that: 1) recognize the heterogeneity and multifactorial nature of dementias; 2) support extensive molecular profiling to fill the gaps in large-scale human data needed to build predictive models of disease and wellness; 3) employ new research paradigms, e.g., systems biology, human cell modeling; 4) enable rapid and extensive sharing of data, disease models, specimens, and support open and team science; 5) develop computational tools and infrastructure for storage, integration, and analysis of large-scale biological and patient-relevant data; 6) build multidisciplinary translational teams in virtual and real spaces; 7) develop new pre-competitive public-private partnerships; 8) change academic, publishing, and funding incentives to promote collaborative, transparent, and reproducible research; and 9) engage patients, caregivers, and citizens as direct partners in research. The Administrative Core will provide scientific leadership to the Rush ADRC as a whole. The Religious Orders Study (ROS) Core will recruit and conduct annual evaluations of Catholic clergy without dementia who agree to organ donation. The Clinical and Latino Cores will collect data harmonized with on Blacks and Latinos without dementia and work to obtain brain autopsy. The Neuropathology Core will process, store, evaluate and distribute biospecimens obtained by the Clinical, ROS, and Latino Cores. The Outreach, Recruitment, and Engagement Core will provide a wide range of educational programs to support outreach and recruitment of racial and ethnic minorities into the Clinical, ROS and Latino Cores, and other NIA funded initiatives. The Biomarker/Neuroimaging Core will process neuroimaging generated with other funds from all three Cores and affiliated studies, and document neuroimaging and biofluid biomarker data. The new Research and Education Component will provide structured mentoring of students and faculty at all levels. The Data Management and Statistical Core will provide the infrastructure that allows all other Cores and the REC to be maximally successful and impactful and will provide statistical support to users of ADRC resources especially junior investigators and trainees.

摘要 - 总体 拟议的Rush ADRC的总体目标是创建一个支持的跨学科环境 关于AD/ADRD的原因，治疗和预防的创新研究。而拟议的Rush Adrc 它是为了新的赠款，它建立在当前的Rush ADCC的三十年中。 Rush Adrc有八个 核心和一个组成部分，与2017年NIA战略计划的建议保持一致，包括 研究：1）认识痴呆症的异质性和多因素性质； 2）支持广泛 分子分析以填补建立疾病和 健康3）员工新的研究范式，例如系统生物学，人类细胞建模； 4）启用快速和 广泛共享数据，疾病模型，标本和支持开放和团队科学； 5）发展 用于存储，集成和分析的大规模生物学和分析的计算工具和基础架构 与患者有关的数据； 6）在虚拟和真实空间中建立多学科翻译团队； 7）开发新 竞争前公私伙伴关系； 8）改变学术，出版和资金激励措施以促进 协作，透明和可再现的研究； 9）与患者，看护人和公民接触 直接合作伙伴研究。 行政核心将为整个Rush ADRC提供科学领导。宗教命令 研究（ROS）核心将招募并进行同意的无痴呆的天主教徒的年度评估 器官捐赠。临床和拉丁裔核心将收集与黑人和拉丁裔协调的数据 痴呆症并努力获得脑尸检。神经病理学核心将处理，存储，评估和 通过临床，ROS和拉丁裔核心获得的分布式生物测量。外展，招聘，以及 参与核心将提供广泛的教育计划，以支持外展和招募 种族和少数民族进入临床，ROS和拉丁裔核心以及其他NIA资助的计划。这 生物标志物/神经成像核心将处理与所有三个核心的其他资金产生的神经影像学，并 附属研究，并记录神经影像学和生物流体生物标志物数据。新的研究和教育 组成部分将在各个级别提供学生和教师的结构化指导。数据管理和 统计核心将提供允许所有其他内核和REC的基础设施 成功且有影响力，并将为ADRC资源的用户提供统计支持 调查人员和学员。

项目成果

Registry-Managed Care Coordination and Education for Patients With Co-occurring Diabetes and Serious Mental Illness.

• DOI: 10.1176/appi.ps.202000096
• 发表时间: 2021-08-01
• 期刊: PSYCHIATRIC SERVICES
• 影响因子: 3.8
• 作者: Cook, Judith A.;Jonikas, Jessica A.;Steigman, Pamela J.;Glover, Crystal M.;Burke-Miller, Jane K.;Weidenaar, Joni;O'Neill, Sheila;Pavick, Debbie;Jami, Asma;Santos, Charles J.
• 通讯作者: Santos, Charles J.

Digital quantification of the MMSE interlocking pentagon areas: a three-stage algorithm.

MMSE 联锁五边形区域的数字量化：三阶段算法。

• DOI: 10.1038/s41598-024-59194-1
• 发表时间: 2024
• 期刊: Scientific reports
• 影响因子: 4.6
• 作者: Kim,Namhee;Truty,Timothy;DukeHan,S;Heo,Moonseong;Buchman,AronS;Bennett,DavidA;Tasaki,Shinya
• 通讯作者: Tasaki,Shinya

Brain Insulin Signaling is Associated with Late-Life Cognitive Decline.

大脑胰岛素信号传导与晚年认知能力下降有关。

• DOI: 10.14336/ad.2023.1117
• 发表时间: 2023
• 期刊: Aging and disease
• 影响因子: 7.4
• 作者: Tong,Han;Capuano,AnaW;Carmichael,OwenT;Gwizdala,KathrynL;Bennett,DavidA;Ahima,RexfordS;Arnold,StevenE;Arvanitakis,Zoe
• 通讯作者: Arvanitakis,Zoe

A public resource of single cell transcriptomes and multiscale networks from persons with and without Alzheimer's disease.

来自阿尔茨海默病患者和非阿尔茨海默病患者的单细胞转录组和多尺度网络的公共资源。

• DOI: 10.1101/2023.10.20.563319
• 发表时间: 2023
• 期刊: bioRxiv : the preprint server for biology
• 作者: Wang,Qi;Antone,Jerry;Alsop,Eric;Reiman,Rebecca;Funk,Cory;Bendl,Jaroslav;Dudley,JoelT;Liang,WinnieS;Karr,TimothyL;Roussos,Panos;Bennett,DavidA;DeJager,PhilipL;Serrano,GeidyE;Beach,ThomasG;Keuren-Jensen,KendallVan;Mast
• 通讯作者: Mast

A brain proteomic signature of incipient Alzheimer's disease in young APOE ε4 carriers identifies novel drug targets.

• DOI: 10.1126/sciadv.abi8178
• 发表时间: 2021-11-12
• 期刊: Science advances
• 影响因子: 13.6
• 作者: Roberts JA;Varma VR;An Y;Varma S;Candia J;Fantoni G;Tiwari V;Anerillas C;Williamson A;Saito A;Loeffler T;Schilcher I;Moaddel R;Khadeer M;Lovett J;Tanaka T;Pletnikova O;Troncoso JC;Bennett DA;Albert MS;Yu K;Niu M;Haroutunian V;Zhang B;Peng J;Croteau DL;Resnick SM;Gorospe M;Bohr VA;Ferrucci L;Thambisetty M
• 通讯作者: Thambisetty M