Washington University Neurosurgery Resident Research Education Program

华盛顿大学神经外科住院医师研究教育计划

• 批准号: 10661573
• 负责人: GREGORY J ZIPFEL
• 金额: --
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-09-30 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10661573
• 关键词: Academic Medical Centers; Academic Training; Award; Basic Science; Benchmarking; Caring; Clinical; Clinical Medicine; Clinical Research; Clinical Sciences; Communities; Country; Dedications; Development; Education; Education Projects; Ensure; Environment; Etiology; Extramural Activities; Face; Faculty; Feedback; Fellowship; Fostering; Funding; Future; Future Generations; Goals; Grant; Healthcare; Individual; Infrastructure; Institution; Instruction; K-Series Research Career Programs; Laboratories; Leadership; Mentors; Mentorship; Minority; Monitor; National Institute of Neurological Disorders and Stroke; Neurologic; Neurologist; Neurology; Neurosciences; Neurosciences Research; Neurosurgeon; Outcome Measure; Participant; Patients; Physicians; Positioning Attribute; Preparation; Private Practice; Process; Program Evaluation; Qualifying; Records; Research; Research Personnel; Research Support; Research Training; Residencies; Resources; Science; Scientist; Secure; Series; Structure; Time; Training; Translational Research; United States National Institutes of Health; Universities; Washington; Woman; candidate selection; career; career development; economic incentive; education research; experience; faculty mentor; improved; innovation; interest; medical schools; meetings; member; nervous system disorder; neurosurgery; next generation; programs; recruit; responsible research conduct; success

Abstract Young investigators are critical to maintaining the physician-scientist workforce, but keeping this pipeline robust faces a myriad of challenges. These include expanding bureaucracy, greater clinical demands, diminishing research time, rapid pace of advancement in basic science, and limited funding for research training. To create a more seamless pipeline for physician-scientist training in Neurosurgery and Neurology at Washington University School of Medicine (WUSM), we have established this Research Education Program that aims to train and develop the future generation of neurosurgeon- and neurologist-scientists essential for future advances in basic, translational, and clinical neuroscience. The structure of the Research Education Program proposed in this renewal application builds upon the strengths and successes of our original program, but changes it in one fundamental way – the program is now expanded to include both neurosurgery and neurology faculty and trainees. In the first iteration of our program, we focused solely on preparing neurosurgeon-scientists for independent investigative careers. In the current application, we now propose to prepare both neurosurgeon- and neurologist-scientists for investigative careers by enlisting full participation and leadership from the Department of Neurology at WUSM. What has not changed is the overarching goal of the WUSM Resident Education Program: to recruit and prepare the next generation of physician-neuroscientists so that they successfully compete for the best junior faculty positions in the country, secure extramural career development funding including K series grants from the NIH, and ultimately become highly successful physician-scientists. The Departments of Neurosurgery and Neurology at WUSM provide an excellent institutional environment for basic, translational, and clinical neuroscience research and education. Both departments have long and distinguished track records of training academic physician-neuroscientists spanning many decades. This success has been particularly strong over the past 10 years. In Neurosurgery, over 70% of graduates have entered academic practice and nearly 20% of graduates have become successful NIH-funded neurosurgeon- scientists. In Neurology, 66% of graduates have taken positions at academic medical centers, and 30% have received independent fellowship grants, K awards, and/or R01 grants. The proposed Neurosurgery and Neurology Research Education Program leverages our past educational experiences and the strong neuroscience community at WUSM in order to develop an enhanced and distinct research training pipeline, specifically for neurosurgeons and neurologists interested in academic careers as independent researchers, with the overall long-term goal of ensuring that highly-trained physician-scientists will be available to make future advances to reduce the burden of neurological diseases.

抽象的 年轻的研究人员对于维持医师科学家队伍至关重要，但要保持这条管道的稳健 这些挑战包括不断扩大的官僚机构、更大的临床需求、不断减少的挑战。 研究时间长、基础科学进步快、研究培训经费有限。 华盛顿神经外科和神经病学医师科学家培训的更无缝渠道 大学医学院（WUSM），我们建立了这个研究教育计划，旨在培训 培养下一代神经外科医生和神经病学家科学家，这对未来的进步至关重要 基础、转化和临床神经科学。 本次更新申请中提出的研究教育计划的结构建立在以下优势之上 以及我们最初计划的成功，但以一种根本性的方式改变了它——该计划现在得到了扩展 在我们项目的第一次迭代中，我们重点关注神经外科和神经病学的教师和实习生。 在当前的应用程序中，我们仅致力于为神经外科医生科学家做好独立研究职业的准备。 现在建议通过招募充分的人来为神经外科医生和神经病学家的研究生涯做好准备 WUSM 神经病学系的参与和领导没有改变。 WUSM 住院医师教育计划的总体目标：招募和培养下一代 医生神经科学家，以便他们成功竞争全国最好的初级教员职位， 确保获得校外职业发展资金，包括 NIH 的 K 系列补助金，并最终成为 非常成功的医学科学家。 WUSM 的神经外科和神经内科为学生提供了良好的机构环境。 这两个系都有长期的基础、转化和临床神经科学研究和教育。 几十年来在培训学术医师神经科学家方面取得了杰出的记录。 过去 10 年，神经外科领域的成功尤为显着，超过 70% 的毕业生取得了成功。 进入学术实践，近 20% 的毕业生已成为 NIH 资助的成功神经外科医生 在神经病学领域，66% 的毕业生已在学术医疗中心任职，30% 的毕业生已在学术医疗中心任职。 获得独立研究金、K 奖和/或 R01 资助。 神经病学研究教育计划利用我们过去的教育经验和强大的 WUSM 的神经科学社区旨在开发增强且独特的研究培训渠道， 特别针对对作为独立研究人员的学术职业感兴趣的神经外科医生和神经科医生， 确保训练有素的医师科学家能够为未来做出贡献的总体长期目标 减轻神经系统疾病负担的进展。

项目成果

Endothelial nitric oxide synthase mediates endogenous protection against subarachnoid hemorrhage-induced cerebral vasospasm.

• DOI: 10.1161/strokeaha.110.607200
• 发表时间: 2011-03
• 期刊: Stroke
• 影响因子: 8.3
• 作者: Vellimana AK;Milner E;Azad TD;Harries MD;Zhou ML;Gidday JM;Han BH;Zipfel GJ
• 通讯作者: Zipfel GJ

Completion of Gamma Knife radiosurgery for AVM treatment after unplanned interruption-technical note.

意外中断后完成伽玛刀放射外科治疗 AVM 技术说明。

• DOI: 10.1007/s00701-018-3493-0
• 发表时间: 2018
• 期刊: Acta neurochirurgica
• 影响因子: 2.4
• 作者: Raman,HariS;Santanam,Lakshmi;Vellimana,AnanthK;Drzymala,RobertE;Tsien,ChristinaI;Zipfel,GregoryJ
• 通讯作者: Zipfel,GregoryJ

Minocycline protects against delayed cerebral ischemia after subarachnoid hemorrhage via matrix metalloproteinase-9 inhibition.

• DOI: 10.1002/acn3.492
• 发表时间: 2017-12
• 期刊: Annals of clinical and translational neurology
• 影响因子: 5.3
• 作者: Vellimana AK;Zhou ML;Singh I;Aum DJ;Nelson JW;Harris GR;Athiraman U;Han BH;Zipfel GJ
• 通讯作者: Zipfel GJ

Sirtuin 1 Mediates Protection Against Delayed Cerebral Ischemia in Subarachnoid Hemorrhage in Response to Hypoxic Postconditioning.

• DOI: 10.1161/jaha.121.021113
• 发表时间: 2021-10-19
• 期刊: Journal of the American Heart Association
• 影响因子: 5.4
• 作者: Diwan D;Vellimana AK;Aum DJ;Clarke J;Nelson JW;Lawrence M;Han BH;Gidday JM;Zipfel GJ
• 通讯作者: Zipfel GJ

Resting-State Functional Magnetic Resonance Imaging Networks as a Quantitative Metric for Impact of Neurosurgical Interventions.

• DOI: 10.3389/fnins.2021.665016
• 发表时间: 2021
• 期刊: Frontiers in neuroscience
• 影响因子: 4.3
• 作者: Yang PH;Hacker CD;Patel B;Daniel AGS;Leuthardt EC
• 通讯作者: Leuthardt EC