Impacting the oral HPV continuum: prevention, screening, and early detection

影响口腔 HPV 连续体：预防、筛查和早期检测

• 批准号: 10658898
• 负责人: Gypsyamber D'Souza
• 金额: $ 104.79万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-23 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10658898
• 关键词: Behavioral; Biological; Biological Markers; Blood; Cancer Detection; Development; Early Diagnosis; HPV oropharyngeal cancer; HPV-High Risk; Human Papillomavirus; Human papillomavirus 16; Incidence; Individual; Infection; Knowledge; Lesion; Methods; Oral; Oropharyngeal; Persons; Prevention; Risk Factors; Salivary; Screening for cancer; United States; high risk; malignant oropharynx neoplasm; oral HPV; oral HPV infection; prevent; progression risk; screening

Human papillomavirus (HPV) causes the majority of oropharyngeal cancers in the United States, but we do not yet have any effective screening methods to detect these cancers. This knowledge gap is in part due to difficulties identifying oropharyngeal precursor lesions. However, several promising salivary and blood biomarkers have recently emerged that may be good markers of persistent oral HPV16 infection, the presumed pre-cursor to HPV-related oropharyngeal cancer. Given the increasing incidence of HPV-related oropharyngeal cancer, I propose to study the oral HPV continuum to answer the following 4 questions: 1) who is at high- risk for HPV-OPC and would benefit from screening, 2) What are the biologic and behavioral factors promoting oral HPV persistence and how can we reduce their effects, 3) how to optimally screen for persistent oral HPV16 infection and HPV-OPC, and 4) How to follow and treat people who screen positive for these biomarkers to prevent the development of HPV-related oropharyngeal cancer.

在美国，大多数口咽癌是由人乳头瘤病毒 (HPV) 引起的 但我们还没有任何有效的筛查方法来检测这些癌症。这 知识差距的部分原因是难以识别口咽部先兆病变。 然而，最近出现了几种有前途的唾液和血液生物标志物，它们可能是 持续性口腔 HPV16 感染的良好标志物，被认为是 HPV 相关的前体 口咽癌。鉴于 HPV 相关口咽癌的发病率不断增加，我 建议研究口腔 HPV 连续体，以回答以下 4 个问题：1) 谁处于高- HPV-OPC 的风险，并会从筛查中受益，2) 生物学和行为学有何影响？ 促进口腔 HPV 持续存在的因素以及我们如何减少其影响，3) 如何最佳地 筛查持续性口腔 HPV16 感染和 HPV-OPC，以及 4) 如何跟踪和治疗患者 对这些生物标记物进行阳性筛查以预防 HPV 相关疾病的发展 口咽癌。

项目成果

Adjuncts for the evaluation of potentially malignant disorders in the oral cavity: Diagnostic test accuracy systematic review and meta-analysis-a report of the American Dental Association.

• DOI: 10.1016/j.adaj.2017.08.045
• 发表时间: 2017-11
• 期刊: Journal of the American Dental Association (1939)
• 作者: Lingen MW;Tampi MP;Urquhart O;Abt E;Agrawal N;Chaturvedi AK;Cohen E;D'Souza G;Gurenlian J;Kalmar JR;Kerr AR;Lambert PM;Patton LL;Sollecito TP;Truelove E;Banfield L;Carrasco-Labra A
• 通讯作者: Carrasco-Labra A

Differences in the Prevalence of Human Papillomavirus (HPV) in Head and Neck Squamous Cell Cancers by Sex, Race, Anatomic Tumor Site, and HPV Detection Method.

• DOI: 10.1001/jamaoncol.2016.3067
• 发表时间: 2017-02-01
• 期刊: JAMA oncology
• 影响因子: 28.4
• 作者: D'Souza G;Westra WH;Wang SJ;van Zante A;Wentz A;Kluz N;Rettig E;Ryan WR;Ha PK;Kang H;Bishop J;Quon H;Kiess AP;Richmon JD;Eisele DW;Fakhry C
• 通讯作者: Fakhry C

Head and neck squamous cell cancers in the United States are rare and the risk now is higher among white individuals compared with black individuals.

• DOI: 10.1002/cncr.31322
• 发表时间: 2018-05-15
• 期刊: Cancer
• 影响因子: 6.2
• 作者: Fakhry C;Krapcho M;Eisele DW;D'Souza G
• 通讯作者: D'Souza G

Prognostic factors for human papillomavirus-positive and negative oropharyngeal carcinomas.

• DOI: 10.1002/lary.27130
• 发表时间: 2018-08
• 期刊: The Laryngoscope
• 作者: Yin LX;D'Souza G;Westra WH;Wang SJ;van Zante A;Zhang Y;Rettig EM;Ryan WR;Ha PK;Wentz A;Koch W;Eisele DW;Fakhry C
• 通讯作者: Fakhry C

Timing, number, and type of sexual partners associated with risk of oropharyngeal cancer.

• DOI: 10.1002/cncr.33346
• 发表时间: 2021-04-01
• 期刊: Cancer
• 影响因子: 6.2
• 作者: Drake VE;Fakhry C;Windon MJ;Stewart CM;Akst L;Hillel A;Chien W;Ha P;Miles B;Gourin CG;Mandal R;Mydlarz WK;Rooper L;Troy T;Yavvari S;Waterboer T;Brenner N;Eisele DW;D'Souza G
• 通讯作者: D'Souza G