Mayo Alzheimer's Disease Research Center

梅奥阿尔茨海默病研究中心

基本信息

批准号：
10657549
负责人：
RONALD C PETERSEN
金额：
$ 321.81万
依托单位：
MAYO CLINIC ROCHESTER
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-07-01 至 2024-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10657549
关键词：
Acceleration Address Alzheimer disease prevention Alzheimer&apos s Disease Alzheimer&apos s disease patient Alzheimer&apos s disease related dementia Alzheimer’s disease biomarker Area Basic Science Biological Biological Markers Biological Models Cells Clinic Clinical Dementia Development Diagnosis Disease Environment Evolution Florida Frontotemporal Lobar Degenerations Functional disorder General Population Genes Genetic Geographic Locations Goals Grant Image Industrialization Institution Investigation Lewy Body Dementia Lewy Body Disease Link Liquid substance Minnesota National Institute on Aging Neurodegenerative Disorders Participant Pathologic Patient Recruitments Process Randomized, Controlled Trials Research Research Personnel Resources Site Stem Cell Research Structure Theoretical model Training Translations cohort data management education research education resources effective therapy frontotemporal degeneration heuristics induced pluripotent stem cell innovation monocyte neuroimaging neuropathology operation outreach peripheral blood recruit research and development

项目摘要

PROJECT SUMMARY/ABSTRACT - OVERALL The overall goal of Mayo Clinic Alzheimer's Disease Research Center (ADRC) is to provide a structured environment that supports innovative research and enables translation aimed at accelerating the development of effective treatment and prevention for AD patients at all stages of the disease. Our comprehensive ADRC is located in Rochester, Minnesota (MCR), and Jacksonville, Florida (MCF), and shares its operations in all of the Cores between the two geographic sites. The sites are linked electronically yielding a seamless operation. The ADRC will be comprised of seven cores: Administrative Core, Clinical Core, Neuropathology Core, Data Management and Statistical Core, Outreach, Recruitment and Engagement Core, Neuroimaging Core and a new Biomarker Core. In addition, the Center will have a Research Education Component. The Mayo ADRC focuses on both Alzheimer's disease (AD) and Alzheimer's disease related dementias (ADRD) such as frontotemporal lobar degeneration and Lewy body disorders. As such, the theme of the ADRC is Similarities and Differences among Neurodegenerative Diseases. This focus will expand on previous accomplishments of the ADRC across the neurodegenerative disease spectra. The acquisition and development of new biomarkers for the neurodegenerative diseases will be a major focus of the Center, and the recruitment of research participants in all three disorders will enhance randomized controlled trial studies. A major emphasis of the new grant period will be the development of the Research Education Component with activities for trainees at all levels. Mayo Clinic has extensive educational resources for both local and national impact and these resources will be leveraged to attract and retain early stage investigators and those who are new to dementia research with an emphasis on diversity. The Mayo ADRC will interact with other ADRCs on various collaborative efforts and will continue to be a major contributor to the field.

项目概要/摘要 - 总体梅奥诊所阿尔茨海默病研究中心 (ADRC) 的总体目标是提供支持创新研究并实现旨在加速翻译的结构化环境为 AD 患者在疾病的各个阶段开发有效的治疗和预防方法。我们的综合 ADRC 位于明尼苏达州罗彻斯特 (MCR) 和佛罗里达州杰克逊维尔 (MCF)，并且在两个地理位置之间的所有核心中共享其运营。这些网站已链接以电子方式实现无缝操作。 ADRC 将由七个核心组成：行政核心、临床核心、神经病理学核心、数据管理和统计核心、外展、招聘和参与核心、神经影像核心和新的生物标记核心。在此外，该中心还将设有研究教育部分。梅奥 ADRC 重点关注这两方面阿尔茨海默病 (AD) 和阿尔茨海默病相关痴呆 (ADRD)，例如额颞叶痴呆脑叶变性和路易体疾病。因此，ADRC 的主题是相似性和神经退行性疾病之间的差异。这一重点将扩大以前的成就 ADRC 跨越神经退行性疾病谱。新产品的收购和开发神经退行性疾病的生物标志物将成为该中心的主要关注点，并且招募所有三种疾病的研究参与者将加强随机对照试验研究。一个专业新资助期的重点将是研究教育部分的发展为各级学员开展的活动。梅奥诊所拥有广泛的教育资源，适用于当地和国家影响力和这些资源将被用来吸引和留住早期研究人员那些刚接触痴呆症研究并强调多样性的人。梅奥 ADRC 将互动与其他 ADRC 进行各种合作，并将继续成为该领域的主要贡献者。

项目成果

期刊论文数量（5）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Progressive supranuclear palsy can mimic idiopathic normal pressure hydrocephalus: A case series.

DOI：
10.1093/jnen/nlad090
发表时间：
2023-11-20
期刊：
Journal of neuropathology and experimental neurology
影响因子：
3.2
作者：
通讯作者：

Computerized Cognitive Training (CCT) versus Yoga Impact on 12 Month Post Intervention Cognitive Outcome in Individuals with Mild Cognitive Impairment.

DOI：
10.3390/brainsci11080988
发表时间：
2021-07-27
期刊：
Brain sciences
影响因子：
3.3
作者：
Phatak VS;Smith GE;Locke D;Shandera-Ochsner A;Dean PM;Ball C;Gutierrez G;Chandler MJ
通讯作者：
Chandler MJ

Charting the meningeal lymphatic network.