Environmental Agents as Modulators of Disease Processes

环境因素作为疾病过程的调节剂

基本信息

批准号：
10852393
负责人：
B Paige Lawrence
金额：
$ 12.81万
依托单位：
UNIVERSITY OF ROCHESTER
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-07-01 至 2026-03-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10852393
关键词：
Acceleration Address Affect Alzheimer&apos s Disease Alzheimer&apos s disease pathology Alzheimer&apos s disease patient American Area Attenuated Award Bioenergetics Biological Assay Biological Models Brain Caenorhabditis elegans Chemical Exposure Clinical Communities Community Health Education Core Facility Data Deferoxamine Development Disease Educational workshop Electron Transport Environment Environmental Exposure Environmental Health Environmental Impact Environmental Pollutants Environmental Risk Factor Epidemiology Exhibits Faculty Failure Fostering Foundations Future Generations Genetic Goals Health Homeostasis Human Incidence Inductively Coupled Plasma Mass Spectrometry Institution International Intervention Ions Iron Iron Chelation Iron Overload Iron-Regulatory Proteins Knowledge Learning Longevity Mediating Mediator Medical Mentors Metals Methods Mission Mitochondria Modeling Modernization Molecular Movement Movement Disorders National Institute of Environmental Health Sciences Nature Neurons Neurophysiology - biologic function Neurosciences Outcome Outcome Measure Output Oxidative Phosphorylation Oxidative Stress Paralysed Parents Pathogenesis Pathway interactions Positioning Attribute Prevention Process Production Professional Organizations Proteins Public Health Regulation Research Research Personnel Resources Risk Role SLC11A2 gene Science Scientist Signal Pathway Stress Stress Response Signaling Swimming Talents Testing Tissues Translating Visualization age related age related neurodegeneration biological adaptation to stress body system career development collaborative environment combat community engagement community partnership divalent metal environmental agent genetic approach healthspan improved in vivo innovation insight inter-institutional knowledge base member mitochondrial dysfunction mutant nervous system disorder neurotoxicity neurotoxicology neurotransmitter biosynthesis next generation novel pharmacologic prevent programs risk mitigation selenoenzyme sensor skills success supportive environment synergism tool uptake

项目摘要

Abstract of Parent Award The overarching goals of the Rochester Environmental Health Sciences Center (EHSC) are to prevent disease and improve health by advancing innovative and impactful translational environmental health research, engaging communities to address environmental health issues, and enhancing career development of talented environmental health investigators. More specifically, the goals of the Center are to: (1) enrich the ability to hypothesize and implement cutting-edge translational environmental health research using modern approaches that also move knowledge into action; (2) advance science by stimulating the prediction and prevention of detrimental exposures on health across the lifespan by developing and using the best available tools and approaches, and integrating new information to understand cumulative risks; (3) promote career development of the next generation of environmental health investigators in a diverse, inclusive, supportive, and collaborative environment; (4) foster interactions of Center members and community partners to cultivate new ideas and respond to issues of concern at the local, national, and international level; and (5) support existing and build new institutional and inter-institutional partnerships. The Rochester EHSC achieves these goals by providing a framework that is anchored in our overall mission to improve public health through the generation of fundamental knowledge and elaboration of mechanisms by which chemical exposures, alone or through interaction with other modifying factors, contribute to cumulative health risk across the life span. A key strength of the Center is that activities are not siloed within the study of a specific organ system or a single disease. As such, the central theme that integrates EHSC research and community engagement programs is the desire to understand how exposures and interactions of environmental factors affect health and disease across the lifespan. This theme weaves together and synergizes Center member efforts, such that the totality of our impact is greater than each part would achieve on its own. Further supporting the Center is a strong tradition of emphasizing and integrating basic mechanistic research in model systems with clinical and epidemiological approaches, which catalyzes multidirectional transformation of new information into actions. The Center also sustains strong community partnerships that develop, advise, and also learn from new methods and engage diverse communities in our region and across the nation. Unique and expanded strengths of our Center combined with emerging new areas underlie proposed Center activities, programs, and use of resources, and provide the foundation for future success. Further supporting our success is the broad- based scientific diversity of our faculty, which ideally positions us to apply integrative and innovative strategies to address critical questions in environmental health sciences.

父母摘要罗切斯特环境健康科学中心（EHSC）的总体目标是预防疾病并改善通过推进创新和有影响力的转化环境健康研究，使社区与社区联系起来环境健康问题，并加强了才华横溢的环境健康调查人员的职业发展。更多的具体而言，该中心的目标是：（1）丰富假设和实施尖端翻译的能力使用现代方法的环境健康研究也将知识转化为行动；（2）推进科学通过开发和使用最好的可用工具和方法，并集成新信息以了解累积风险；（3）促进职业发展下一代环境卫生调查人员，以多样化，包容性，支持性和协作环境；（4）促进中心成员和社区合作伙伴的互动，以培养新想法和回应当地，国家和国际层面的关注问题；（5）支持现有并建立新的机构和机构间合作伙伴关系。罗切斯特EHSC通过提供一个锚定框架来实现这些目标在我们的整体使命中，通过基本知识和阐述来改善公共卫生化学暴露单独或通过与其他修饰因素相互作用的机制有助于整个生命周期的累积健康风险。中心的关键优势是在研究中没有孤立活动特定器官系统或单一疾病。因此，集成了EHSC研究和社区的中心主题参与计划是了解环境因素的暴露和相互作用如何影响健康和整个生命周期的疾病。这个主题编织在一起并协同中心成员的努力，使我们的整体影响要比每个部分自己实现的要大。进一步支持该中心是强调的强烈传统并将模型系统中的基本机械研究与临床和流行病学方法相结合，从而催化将新信息转换为动作。该中心还维持强大的社区伙伴关系这会发展，建议并从新方法中学习，并吸引我们地区和全国各地的各种社区。我们中心的独特和扩展的优势结合了拟议中心活动的新兴领域，计划和使用资源，并为未来的成功奠定了基础。进一步支持我们的成功是广泛的我们教师的基于科学多样性，理想地将我们定位为应用综合和创新策略来解决环境健康科学中的关键问题。