Environmental Agents as Modulators of Disease Processes

环境因素作为疾病过程的调节剂

基本信息

批准号：
10852393
负责人：
B Paige Lawrence
金额：
$ 12.81万
依托单位：
UNIVERSITY OF ROCHESTER
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-07-01 至 2026-03-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10852393
关键词：
Acceleration Address Affect Alzheimer&apos s Disease Alzheimer&apos s disease pathology Alzheimer&apos s disease patient American Area Attenuated Award Bioenergetics Biological Assay Biological Models Brain Caenorhabditis elegans Chemical Exposure Clinical Communities Community Health Education Core Facility Data Deferoxamine Development Disease Educational workshop Electron Transport Environment Environmental Exposure Environmental Health Environmental Impact Environmental Pollutants Environmental Risk Factor Epidemiology Exhibits Faculty Failure Fostering Foundations Future Generations Genetic Goals Health Homeostasis Human Incidence Inductively Coupled Plasma Mass Spectrometry Institution International Intervention Ions Iron Iron Chelation Iron Overload Iron-Regulatory Proteins Knowledge Learning Longevity Mediating Mediator Medical Mentors Metals Methods Mission Mitochondria Modeling Modernization Molecular Movement Movement Disorders National Institute of Environmental Health Sciences Nature Neurons Neurophysiology - biologic function Neurosciences Outcome Outcome Measure Output Oxidative Phosphorylation Oxidative Stress Paralysed Parents Pathogenesis Pathway interactions Positioning Attribute Prevention Process Production Professional Organizations Proteins Public Health Regulation Research Research Personnel Resources Risk Role SLC11A2 gene Science Scientist Signal Pathway Stress Stress Response Signaling Swimming Talents Testing Tissues Translating Visualization age related age related neurodegeneration biological adaptation to stress body system career development collaborative environment combat community engagement community partnership divalent metal environmental agent genetic approach healthspan improved in vivo innovation insight inter-institutional knowledge base member mitochondrial dysfunction mutant nervous system disorder neurotoxicity neurotoxicology neurotransmitter biosynthesis next generation novel pharmacologic prevent programs risk mitigation selenoenzyme sensor skills success supportive environment synergism tool uptake

项目摘要

Abstract of Parent Award The overarching goals of the Rochester Environmental Health Sciences Center (EHSC) are to prevent disease and improve health by advancing innovative and impactful translational environmental health research, engaging communities to address environmental health issues, and enhancing career development of talented environmental health investigators. More specifically, the goals of the Center are to: (1) enrich the ability to hypothesize and implement cutting-edge translational environmental health research using modern approaches that also move knowledge into action; (2) advance science by stimulating the prediction and prevention of detrimental exposures on health across the lifespan by developing and using the best available tools and approaches, and integrating new information to understand cumulative risks; (3) promote career development of the next generation of environmental health investigators in a diverse, inclusive, supportive, and collaborative environment; (4) foster interactions of Center members and community partners to cultivate new ideas and respond to issues of concern at the local, national, and international level; and (5) support existing and build new institutional and inter-institutional partnerships. The Rochester EHSC achieves these goals by providing a framework that is anchored in our overall mission to improve public health through the generation of fundamental knowledge and elaboration of mechanisms by which chemical exposures, alone or through interaction with other modifying factors, contribute to cumulative health risk across the life span. A key strength of the Center is that activities are not siloed within the study of a specific organ system or a single disease. As such, the central theme that integrates EHSC research and community engagement programs is the desire to understand how exposures and interactions of environmental factors affect health and disease across the lifespan. This theme weaves together and synergizes Center member efforts, such that the totality of our impact is greater than each part would achieve on its own. Further supporting the Center is a strong tradition of emphasizing and integrating basic mechanistic research in model systems with clinical and epidemiological approaches, which catalyzes multidirectional transformation of new information into actions. The Center also sustains strong community partnerships that develop, advise, and also learn from new methods and engage diverse communities in our region and across the nation. Unique and expanded strengths of our Center combined with emerging new areas underlie proposed Center activities, programs, and use of resources, and provide the foundation for future success. Further supporting our success is the broad- based scientific diversity of our faculty, which ideally positions us to apply integrative and innovative strategies to address critical questions in environmental health sciences.

家长奖摘要罗切斯特环境健康科学中心 (EHSC) 的总体目标是预防疾病和改善健康通过推进创新和有影响力的转化环境健康研究，让社区参与解决问题环境健康问题，并促进有才华的环境健康调查人员的职业发展。更多的具体来说，中心的目标是：（1）丰富前沿转化假设和实施的能力使用现代方法进行环境健康研究，并将知识转化为行动； (2) 推动科学发展通过开发和使用刺激预测和预防整个生命周期中对健康有害的暴露最佳可用工具和方法，并整合新信息以了解累积风险；（三）促进事业发展以多元化、包容性、支持性和包容性的方式培养下一代环境卫生调查员协作环境； (4) 促进中心成员和社区合作伙伴的互动，以培育新思想和回应地方、国家和国际层面关注的问题； (5) 支持现有的和建立新的机构和机构间伙伴关系。罗切斯特 EHSC 通过提供一个锚定的框架来实现这些目标我们的总体使命是通过生成基础知识和阐述来改善公共卫生化学品暴露单独或通过与其他改变因素相互作用导致的机制整个生命周期的累积健康风险。该中心的一个关键优势是，活动不是孤立在某个研究范围内的。特定器官系统或单一疾病。因此，整合 EHSC 研究和社区的中心主题参与计划是了解环境因素的暴露和相互作用如何影响健康和疾病贯穿一生。这个主题将中心成员的努力编织在一起并发挥协同作用，从而使我们的整体影响比每个部分单独实现的影响更大。进一步支持该中心是强调并将模型系统中的基础机制研究与临床和流行病学方法相结合，从而促进将新信息多向转化为行动。该中心还维持强大的社区伙伴关系开发新方法、提供建议并学习新方法，并吸引我们地区和全国各地的不同社区参与。我们中心的独特和扩展的优势与新兴的新领域相结合，构成了拟议的中心活动的基础，计划和资源的使用，并为未来的成功奠定基础。进一步支持我们成功的是广泛的基于我们教师的科学多样性，这使我们能够应用综合和创新策略来解决环境健康科学中的关键问题。