Center Core Grant for Vision Research

视觉研究中心核心资助

• 批准号: 10714512
• 负责人: Mahnaz Shahidi
• 金额: $ 65.23万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-30 至 2028-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10714512
• 关键词: Animal Model; Biology; California; Center Core Grants; Data Science Core; Dedications; Diagnosis; Emerging Technologies; Engineering; Ensure; Environment; Eye diseases; Fostering; Functional disorder; Funding; Goals; Grant; Interdisciplinary Study; K-Series Research Career Programs; Knowledge; Mentors; Productivity; Research; Research Personnel; Research Project Grants; Resource Sharing; Resources; Technical Expertise; Therapeutic; Tissue imaging; United States National Institutes of Health; Universities; Vision research; Visual System; Visual impairment; cellular imaging; collaborative environment; experience; imaging science; in vivo imaging; innovation; innovative technologies; instrumentation; novel diagnostics; novel therapeutic intervention; programs; success; vision development; vision science

PROJECT SUMMARY: OVERALL CENTER CORE The overarching goal of the Center Core Grant for Vision Research is to support, strengthen and broaden basic and translational vision science research at the University of Southern California. The Center Core will provide shared resources accessible to a group of 28 outstanding investigators, dedicated to elucidating mechanisms, diagnosis, and treatment of ocular diseases. Currently, these participating investigators cumulatively hold 28 NIH-funded research grants, consisting of 21 grants from NEI (13 R01s, 1 R21, 7 K- awards) and 7 grants from other institutes (4 R01s, 1 R21, 1 RF1, 1 K08). The Center Core will support 3 highly integrated Resource Cores: 1) Ophthalmic Therapeutics Engineering Core, 2) Cell & Tissue Imaging and Data Science Core, 3) Animal Models and In Vivo Imaging Core. These Cores will offer exceptional facilities, instrumentation and expertise that are essential resources to enhance and expand the research programs of participating investigators, aid established investigators in pursuing research in new emerging fields, and assist new investigators in developing vision research projects. The Center Core will also coordinate and integrate Core activities, promote utilization of innovative emerging technologies, and facilitate collaborative inter-disciplinary vision research. The Center Core will serve as a cornerstone for conduct of impactful basic and translational vision research focused on advancing knowledge of the biology and pathophysiology of the visual system and development of novel diagnostic and therapeutic approaches for vision impairment.

项目概要：整体中心核心 视觉研究中心核心拨款的总体目标是支持、加强和扩大 南加州大学的基础和转化视觉科学研究。中心核心将 为 28 名杰出研究人员提供可访问的共享资源，致力于阐明 眼部疾病的机制、诊断和治疗。目前，这些参与研究人员 累计持有 28 项 NIH 资助的研究经费，其中 21 项来自 NEI（13 R01s、1 R21、7 K- 奖）和其他机构的 7 项资助（4 R01、1 R21、1 RF1、1 K08）。中心核心将支持 3 高度集成的资源核心：1) 眼科治疗工程核心，2) 细胞和组织成像 和数据科学核心，3) 动物模型和体内成像核心。这些核心将提供卓越的 设施、仪器和专业知识是加强和扩大研究的重要资源 参与研究人员的计划，援助已建立的研究人员在新兴领域进行研究 领域，并协助新研究人员开发视觉研究项目。中心核心还将 协调和整合核心活动，促进创新新兴技术的利用，并促进 合作的跨学科视觉研究。中心核心将作为开展以下活动的基石 有影响力的基础和转化视觉研究，专注于推进生物学和 视觉系统的病理生理学以及新型诊断和治疗方法的开发 视力障碍。

项目成果

Loss of 15-Lipoxygenase in Retinodegenerative RCS Rats.

视网膜变性 RCS 大鼠中 15-脂氧合酶的丧失。

• 发表时间: 2024-02-15
• 影响因子: 5.6
• 作者: Mead, Andrew James;Ahluwalia, Kabir;Ebright, Brandon;Zhang, Zeyu;Dave, Priyal;Li, Zeyang;Zhou, Eugene;Naik, Aditya Anil;Ngu, Rachael;Chester, Catherine;Lu, Angela;Asante, Isaac;Pollalis, Dimitrios;Martinez, Juan Carlos;Humayun, Mark;Louie
• 通讯作者: Louie

Design and Simulation of a Ring Transducer Array for Ultrasound Retinal Stimulation.

用于超声视网膜刺激的环形换能器阵列的设计和仿真。

• 发表时间: 2022-09-16
• 影响因子: 3.4
• 作者: Xu, Chenlin;Lu, Gengxi;Kang, Haochen;Humayun, Mark S;Zhou, Qifa
• 通讯作者: Zhou, Qifa

A retinal imaging system for combined measurement of optic nerve head vascular pulsation and stimulated vasodilation in humans.

一种视网膜成像系统，用于联合测量人类视神经乳头血管搏动和刺激血管舒张。

• 发表时间: 2023-10-10
• 影响因子: 4.6
• 作者: Felder, Anthony E;Rahimi, Mansour;Nankali, Amir;Matei, Nathanael;Abdolahi, Farzan;Blair, Norman P;Shahidi, Mahnaz
• 通讯作者: Shahidi, Mahnaz

Isolation and Characterization of Extracellular Vesicles Through Orthogonal Approaches for the Development of Intraocular EV Therapy.

通过正交方法分离和表征细胞外囊泡以开发眼内 EV 疗法。

• 发表时间: 2024-03-05
• 影响因子: 4.4
• 作者: Leung, Justin;Pollalis, Dimitrios;Nair, Gopa K G;Bailey, Jeffrey K;Pennington, Britney O;Khan, Amir I;Kelly, Kaitlin R;Yeh, Ashley K;Sundaram, Kartik S;Clegg, Dennis O;Peng, Chen;Xu, Liya;Lee, Sun Young
• 通讯作者: Lee, Sun Young

Ultrasonic Retinal Neuromodulation and Acoustic Retinal Prosthesis.

超声视网膜神经调节和声学视网膜假体。

• 发表时间: 2020-10-13
• 影响因子: 3.4
• 作者: Lo, Pei;Huang, Kyana;Zhou, Qifa;Humayun, Mark S;Yue, Lan
• 通讯作者: Yue, Lan