The Neural Basis of Active Sensory Gain Suppression in the Somatosensory System

体感系统中主动感觉增益抑制的神经基础

• 批准号: 10656346
• 负责人: Manuel Gomez-Ramirez
• 金额: $ 23.51万
• 依托单位: UNIVERSITY OF ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-07-01 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10656346
• 关键词: Animals; Area; Attention; Attention deficit hyperactivity disorder; Award; Behavior; Behavioral; Brain; Calcium; Cells; Central Nervous System; Cities; Cognitive Science; Communication; Cortical Column; Cutaneous; D Cells; Data; Development; Discrimination; Doctor of Philosophy; Electrodes; Electrophysiology (science); Ensure; Environment; Faculty; Fellowship; Fingers; Functional Magnetic Resonance Imaging; Genetic; Goals; Grant; Hand; Human; Human Resources; Image; Injections; Interneurons; Learning; Link; Location; Macaca mulatta; Manuscripts; Maps; Mediating; Mentors; Methods; Modality; Modeling; Monitor; Monkeys; Mus; Neocortex; Neurons; New York; Optical Methods; Perception; Personnel Management; Persons; Play; Population; Positioning Attribute; Postdoctoral Fellow; Process; Recurrence; Research; Research Training; Role; Scalp structure; Sensory; Series; Signal Transduction; Skin; Somatosensory Cortex; Somatostatin; Stimulus; System; Tactile; Techniques; Testing; Texture; Time; Training; Universities; Viral; Writing; analytical method; attentional control; autism spectrum disorder; brain machine interface; career; cell cortex; college; experimental study; flexibility; haptics; insight; neocortical; neural; neural circuit; neuroprosthesis; neuroregulation; neurotransmission; nonhuman primate; optogenetics; professor; programs; receptive field; receptor; response; role model; selective attention; senior faculty; sensory stimulus; simulation; somatosensory; theories; translational impact; vibration

PROJECT SUMMARY The candidate: Dr. Manuel Gomez-Ramirez is an Assistant Professor in the Department of Brain and Cognitive Sciences (BCS) at the University of Rochester, whose overarching goal is to establish cutting-edge research program focused on studying neural circuits and spiking dynamics that mediate object sensing and manipulation with the hands (i.e., haptics). Dr. Gomez-Ramirez completed his Ph.D. at the City College of the City University of New York studying mechanisms of distracter suppression in humans. He transitioned to studying mechanisms of tactile perception in non-human primates using multi-electrode single-unit recordings at the Johns Hopkins University. He conducted a second post-doctoral fellowship at Brown University to learn calcium-based imaging and optogenetic methods in mice. In his new lab, Dr. Gomez-Ramirez aims to incorporate techniques learned in his post-doctoral fellowships to study haptics in a non-human primate model. Research: In this award, Dr. Gomez-Ramirez will study how selective attention controls the sensory gain of neocortical representations encoding distracter stimuli on the hand. He will use cutting-edge electrophysiological and neuromodulation methods (i.e., optogenetics) to determine the neural circuit, and its dynamics, that mediate sensory suppression of distracting tactile inputs. Aim 1 investigates the granularity of attention to modulate sensory responses via targeting of cells’ receptive field (RF) inhibitory and/or excitatory sub-regions. Aim 2 investigates the precision and flexibility of attention to deploy distracter suppression across different somatotopic representations in the somatosensory system. Aim 3 tests the role of layer 5 SST neurons in mediating sensory gain suppression in supragranular layers, the mayor cortical layer of intra- and inter-area communication. Training, Mentors, Collaborators, and Environment: The major research training goals of this award are to gain expertise in (1) Cutting-edge population decoding methods (e.g., state-space analytical methods), and (2) optogenetic stimulation in monkeys to study the how top-down signals regulate local somatosensory cortical circuits representing relevant vs. irrelevant tactile information. This award will also provide key training in grant and manuscript writing, personnel management, as well as engagement in extracurricular activities that will enhance my career and professional development. The K01 scientific mentoring team comprises world-experts in their respective field of research, and have been role models for mentoring and supporting junior faculty. The Tenure Oversight team is composed additional senior faculty that will provide another layer of monitoring to ensure progress in the activities proposed in the tenure plan. Impact and Significance: Data gathered from studies in this award will inform an R01 application focused on studying how top-down signals modulate cross-cortical somatosensory circuits mediating object sensing and manipulation. This award will help provide training on cutting-edge electrophysiological, computational, and genetic-based optical methods to personnel in the Dr. Gomez-Ramirez’s lab.

项目摘要 候选人：Manuel Gomez-Ramirez博士是大脑和认知系的助理教授 罗切斯特大学的科学（BCS），其总体目标是建立尖端研究 旨在研究介导对象敏感性和操纵的神经元电路和尖峰动态的程序 用手（即触觉）。戈麦斯 - 拉米雷斯博士完成了博士学位。在城市大学的城市学院 纽约研究人类干扰物抑制的机制。他过渡到研究机制 在约翰·霍普金斯（Johns Hopkins）的多电极单单元录音中，非人类素数中的触觉感知 大学。他在布朗大学进行了第二次博士后奖学金，以学习基于钙的成像 和小鼠的光遗传学方法。在他的新实验室中，戈麦斯·拉米雷斯（Gomez-Ramirez）博士旨在纳入从中学到的技术 他在非人类私人模型中学习触觉的博士后研究金。 研究：在该奖项中，戈麦斯 - 拉米雷斯博士将研究选择性注意力如何控制感官增长 新皮层表示，编码手上的干扰物刺激。他将使用尖端的电生理学 和神经调节方法（即光遗传学）来确定神经信号及其动力学，以介导 对分散注意力的触觉输入的感觉抑制。 AIM 1研究了注意的粒度 通过靶向细胞接受场（RF）抑制性和/或兴奋性子区域的感觉反应。目标2 调查注意力抑制分散分散抑制的精确性和灵活性 体感系统中的表示形式。 AIM 3测试第5层SST神经元在介导感觉中的作用 在上层和区域间交流的市长皮层层中获得抑制。 培训，导师，合作者和环境：该奖项的主要研究培训目标是 获得（1）最先进的人口解码方法（例如状态空间分析方法）和（2）的专业知识 猴子中的光遗传学模拟研究自上而下的信号如何调节局部体感皮质 代表相关与无关触觉信息的电路。该奖项还将提供赠款的关键培训 以及手稿写作，人事管理以及参与课外活动 增强我的职业和专业发展。 K01科学心理团队包括世界专家 在各自的研究领域，一直是心理和支持初级教师的榜样。 任期监督团队是额外的高级教师 确保终身计划中提出的活动的进展。 影响和意义：从该奖项中收集的数据收集的数据将为R01申请提供介绍 研究自上而下的信号如何调节跨皮质体感电路介导对象灵敏度和 操纵。该奖项将有助于提供有关尖端电生理，计算和 戈麦斯 - 拉米雷斯博士实验室中人员的基于遗传的光学方法。