A Mentoring Program in Kidney Care for Older Adults

老年人肾脏护理指导计划

• 批准号: 10656289
• 负责人: MANJULA KURELLA TAMURA
• 金额: $ 13.76万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-06-15 至 2027-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10656289
• 关键词: Acute Renal Failure with Renal Papillary Necrosis; Adult; Advance Care Planning; Affect; Age; Aging; Antihypertensive Agents; Area; Award; Benefits and Risks; Blood Pressure; Cardiovascular system; Caring; Cessation of life; Chronic Kidney Failure; Clinical Trials; Data; Decision Analysis; Dedications; Dialysis procedure; Diastolic blood pressure; Discipline; Disease Management; Disease Progression; Education; Elderly; Electrolyte Disorder; Electronic Health Record; Event; Fostering; Frail Elderly; Funding; Future; Glucose; Goals; Grant; Guidelines; Health Services; Hypertension; Impaired cognition; Interdisciplinary Study; Intervention; Investigation; Journals; Kidney; Kidney Diseases; Knowledge; Mentors; Methodology; Methods; Midcareer Investigator Award in Patient-Oriented Research; Mineralocorticoid Receptor; Modeling; Nursing Homes; Outcome; Patient-Focused Outcomes; Patients; Pharmaceutical Preparations; Policies; Policy Maker; Population; Positioning Attribute; Program Sustainability; Publishing; Pulse Pressure; Recommendation; Renal function; Renin-Angiotensin-Aldosterone System; Research; Research Personnel; Research Project Grants; Research Support; Resources; Risk Reduction; Scientist; Serious Adverse Event; Shapes; Sodium; Structure; Study models; Systolic Pressure; Target Populations; Time; Training; Training Programs; United States Department of Veterans Affairs; Universities; Work; antagonist; cardiovascular risk factor; career; career development; clinical center; cohort; comparative; experience; hypertension treatment; inhibitor; mortality; multidisciplinary; next generation; novel; novel strategies; patient oriented; patient population; profiles in patients; programs; randomized trial; skills; symporter; tool; training opportunity; treatment effect

PROJECT SUMMARY/ABSTRACT This proposal for a Midcareer Investigator Award in Patient-Oriented Research (K24) will support the research program of Dr. Manjula Kurella Tamura, a nephrologist at Stanford University and Director of the Veterans Affairs Palo Alto Geriatric Research and Education Clinical Center. The candidate leads a multi-disciplinary research program which is focused on patient-centered outcomes of dialysis treatment in older adults. Her research program, comprised of a health services component and an interventions component, has been supported by five federally funded awards during the past five years, and has produced an extensive portfolio of work to support hypothesis driven mentee research. During this time, the candidate’s research program has provided training opportunities for 13 junior investigators who have successfully obtained funding, published research in high-impact journals, and transitioned into academic positions. In this K24 application, her overarching goal is to grow and sustain this program by: (1) enhancing her skills as a research mentor by obtaining training in key areas, and (2) using her research as a platform to mentor trainees from a range of disciplines, and (3) extending her research to evaluate treatment trade-offs earlier in the course of kidney disease. Recent clinical trials demonstrate that intensive versus standard blood pressure targets reduce mortality and cardiovascular events, but at the expense of kidney function. The scientific goal of this application is to evaluate the comparative harms and benefits of intensive versus standard hypertension treatment and hypertension deprescribing on kidney end-points in two real world older adult cohorts. The secondary goal is to demonstrate the application of novel analytical approaches that extend causal effects from randomized trials to older and sicker populations. The candidate’s mentoring program will integrate resources from the breadth of training programs at Stanford and VA Palo Alto, with unique opportunities tailored to the career development of scientists in aging research.

项目概要/摘要 这项以患者为导向的研究中职业生涯研究者奖 (K24) 的提案将 支持斯坦福大学肾病专家 Manjula Kurella Tamura 博士的研究项目 帕洛阿尔托大学和退伍军人事务部主任老年研究和教育 临床中心候选人领导一个多学科研究项目，重点关注 她的研究项目以患者为中心的老年人透析治疗结果。 由卫生服务部分和干预部分组成 在过去五年中得到了五项联邦资助的奖项的支持，并产生了 在此期间，支持假设驱动的受训者研究的广泛工作组合。 候选人的研究计划为 13 名初级研究员提供了培训机会，他们 已成功获得资助，在高影响力期刊上发表研究成果，并完成转型 在这个 K24 申请中，她的首要目标是发展和维持这一点。 计划通过：（1）通过获得关键领域的培训来提高她作为研究导师的技能， (2) 利用她的研究作为平台来指导各个学科的学员，以及 (3) 将她的研究扩展到评估肾脏疾病早期的治疗权衡。 最近的临床试验表明，强化血压目标与标准血压目标相比会降低 死亡率和心血管事件，但以牺牲肾功能为代价。 该应用程序旨在评估强化与标准的相对危害和益处 两个现实世界中的高血压治疗和高血压对肾脏终点的处方减少 第二个目标是展示新颖的分析方法的应用。 将随机试验的因果效应扩展到老年人和病情较重的人群的方法。 候选人的指导计划将整合各种培训资源 斯坦福大学和弗吉尼亚州帕洛阿尔托的课程，提供适合职业生涯的独特机会 科学家在衰老研究方面的发展。

项目成果

Estimated Effect of Parathyroidectomy on Long-Term Kidney Function in Adults With Primary Hyperparathyroidism.

甲状旁腺切除术对原发性甲状旁腺功能亢进症成人长期肾功能的估计影响。

• DOI: 10.7326/m22-2222
• 发表时间: 2023
• 期刊: Annals of internal medicine
• 影响因子: 39.2
• 作者: Seib,CarolynD;Ganesan,Calyani;Furst,Adam;Pao,AlanC;Chertow,GlennM;Leppert,JohnT;Suh,Insoo;Montez-Rath,MariaE;Harris,AlexHS;Trickey,AmberW;Kebebew,Electron;KurellaTamura,Manjula
• 通讯作者: KurellaTamura,Manjula