University of Texas Southwestern - Stimulating Access to Research in Residency (UT-StARR) Program

德克萨斯大学西南分校 - 促进住院医师研究 (UT-StARR) 计划

• 批准号: 10655275
• 负责人: DWIGHT A. TOWLER
• 金额: $ 33.48万
• 依托单位: UT SOUTHWESTERN MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-07-01 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10655275
• 关键词: Address; Adult; Affect; Asian; Asian Indian; Biomedical Research; Black race; Blood; Breeding; Bronchopulmonary Dysplasia; Cardiovascular Diseases; Cessation of life; Childhood; Chronic Disease; Clinical; Clinical Research; Communities; Conceptions; Congenital Heart Defects; Cystic Fibrosis; Detection; Development; Diagnostic; Disease; Doctor of Medicine; Ensure; Environment; Equilibrium; Evaluation; Faculty; Foundations; Funding; Future; Hawaiian; Health; Heart; Heart Diseases; Hemophilia A; Hispanic; Hospitalization; Hospitals; Human; Individual; Institution; Internal Medicine; Intervention; Investigation; Laboratories; Longevity; Lung; Lung diseases; Maintenance; Medical Students; Mentors; Minority; Monitor; Outcome; Patient Recruitments; Patients; Pediatrics; Physicians; Population; Population Heterogeneity; Population Research; Prevention; Race; Research; Research Personnel; Research Priority; Research Training; Residencies; Risk; Scientist; Teaching Hospitals; Texas; Training; Training Programs; Translational Research; Underrepresented Populations; United States National Institutes of Health; Universities; Woman; career; design; disability; disease prognosis; experience; faculty mentor; health disparity; human disease; improved; innovation; interest; medical schools; member; multidisciplinary; next generation; patient population; personalized medicine; population health; programs; recruit; skills; strength training

Project Abstract Despite decades of research in the understanding and treatment of diseases of the heart and lung, cardiovascular and pulmonary diseases remain the leading causes of hospitalization, disability, and death in the U.S. Notably, growing numbers of patients with childhood-onset chronic illnesses, such as congenital heart defects, cystic fibrosis, bronchopulmonary dysplasia, and hemophilia, are surviving into adulthood, making it imperative to conduct research encompassing the lifespan. Against this background of critical research needs, there is a strikingly growing shortage of M.D.-scientists, such that the proportion of M.D.s that remain primarily in research careers has decreased by 3-fold in the last 3 decades, despite the climbing number of total physicians in practice. The pipeline of M.D.-scientist development is also at risk: fewer medical students express interest in a research career, and fewer graduates apply for NIH funding. Importantly, relative to the overall physician workforce, women and minorities are disproportionately underrepresented in the proportion of M.D.-scientists. These challenges require the implementation of innovative recruitment and training strategies to feed the M.D.- scientist pipeline and ensure that women and minorities are well-represented. To help fill these critical gaps, we will establish the University of Texas Southwestern (UTSW) - Stimulating Access to Research in Residency (UT-StARR) training program to recruit and train a diverse group of Internal Medicine and Pediatrics residents that will become the next generation of M.D.-scientists conducting laboratory-based, translational, clinical, and population health research to detect, treat, and prognosticate diseases affecting the heart, lungs, and blood of diverse populations throughout the lifespan. Our institution will provide an ideal environment with a multidisciplinary cadre of funded research; robust didactic training program; and diverse patient population. We hypothesize that the 3 axes of diversity at UTSW - M.D. trainees, mentors, and patient community - afford the unique opportunity to address unmet needs in M.D. research training, personalized medicine, and population health. The following Aims organize our approach: Aim 1. To provide broad-based comprehensive mentored research training for a group of diverse Internal Medicine and Pediatric resident-investigators in the conception, design, and implementation of laboratory-based, translational, clinical, and population research in diseases affecting the heart, lungs and blood, encompassing detection, prevention, treatment, and outcomes to improve the health of individuals and populations throughout the human lifespan; Aim 2. To provide the essential research training and mentoring platform needed to build a strong foundation allowing successful transition of residents to independent M.D.-scientists conducting biomedical research in the heart, lung, and blood fields; Aim 3. To enhance the participation and persistence of M.D.s from underrepresented groups in research by implementation and maintenance of institutional mentored residency training programs involving diverse residents, mentors, and patients through evaluation and monitoring the progress of UT-StARR and other institutional training programs.

项目摘要 尽管在理解和治疗心脏和肺部疾病方面进行了数十年的研究，但 心血管和肺部疾病仍然是住院，残疾和死亡的主要原因 美国尤其是，越来越多的儿童慢性病患者，例如先天性心脏 缺陷，囊性纤维化，支气管肺发育不良和血友病，已存活到成年 必须进行涵盖寿命的研究。在关键研究需求的背景下 M.D.科学家的短缺大大不足，因此主要保持的M.D.的比例 在过去的3年中，研究职业在3倍中下降了3倍，尽管医师总数有所攀升 实践。医学博士学位发展的管道也有风险：较少的医学生对 研究职业，较少的毕业生申请NIH资金。重要的是，相对于整体医师 劳动力，妇女和少数民族在医学博士学位的比例中的人数不足。 这些挑战需要实施创新的招聘和培训策略，以喂养医学博士 - 科学家管道，并确保妇女和少数民族的代表性很好。为了填补这些关键空白，我们 将建立德克萨斯大学西南大学（UTSW） - 刺激研究的访问 居住（UT-Starr）培训计划，旨在招募和培训各种各样的内科和儿科 将成为下一代医学博士学位的居民 临床和人群健康研究以检测，治疗和预后疾病影响心脏，肺， 在整个生命周期中的血液和多样化人群的血液。我们的机构将提供一个理想的环境 资助研究的多学科干部；强大的教学培训计划；和多样化的患者人数。我们 假设UTSW -M.D.学员，导师和患者社区的三个多样性轴线负担得起 在医学博士研究培训，个性化医学和人群中解决未满足需求的独特机会 健康。以下目的组织了我们的方法：目标1。提供广泛的综合指导 在构想中，针对一组多样的内科和小儿居民评估者的研究培训， 疾病中基于实验室，转化，临床和人群研究的设计和实施 影响心脏，肺和血液，包括检测，预防，治疗和结果 整个人类寿命的个人和人口的健康；目标2。提供基本的研究 培训和指导平台需要建立坚实的基础，以成功地过渡居民 独立的医学博士学家在心脏，肺和血田中进行生物医学研究；目标3 通过实施来增强代表性不足的小组中的M.D.s的参与和持久性 以及维护机构导师的居住培训计划，涉及多元化居民，导师和 通过评估和监测UT-Starr和其他机构培训计划的进度来患者。

项目成果

Novel Biomarkers of Kidney Disease in Advanced Heart Failure: Beyond GFR and Proteinuria.

• DOI: 10.1007/s11897-022-00557-y
• 发表时间: 2022-08
• 期刊: Current heart failure reports

Association of Ratio of eGFR by Cystatin C and Creatinine with Mortality in Heart Failure.

胱抑素 C 和肌酐的 eGFR 比率与心力衰竭死亡率的关联。

• DOI: 10.34067/kid.0000000000000384
• 发表时间: 2024
• 期刊: Kidney360
• 作者: Roehm,Bethany;McAdams,Meredith;Gordon,Jonathan;Grodin,JustinL;Hedayati,SSusan
• 通讯作者: Hedayati,SSusan

Specific Gravity Improves Identification of Clinically Significant Quantitative Proteinuria from the Dipstick Urinalysis.

比重可改善试纸尿液分析中临床显着的定量蛋白尿的识别。

• DOI: 10.34067/kid.0000000000000452
• 发表时间: 2024
• 期刊: Kidney360
• 作者: McAdams,MeredithC;Gregg,LParker;Xu,Pin;Zhang,Song;Li,Michael;Carroll,Ella;Kannan,Vaishnavi;Willett,DuWayneL;Hedayati,SSusan
• 通讯作者: Hedayati,SSusan

Patterns of Referral and Postdischarge Utilization of Cardiac Rehabilitation Among Patients Hospitalized With Heart Failure: An Analysis From the GWTG-HF Registry.

心力衰竭住院患者的转诊和出院后心脏康复利用模式：来自 GWTG-HF 登记处的分析。

• DOI: 10.1161/circheartfailure.122.010144
• 发表时间: 2023
• 期刊: Circulation. Heart failure
• 作者: Keshvani,Neil;Subramanian,Vinayak;Wrobel,ChristopherA;Solomon,Nicole;Alhanti,Brooke;Greene,StephenJ;DeVore,AdamD;Yancy,ClydeW;Allen,LarryA;Fonarow,GreggC;Pandey,Ambarish
• 通讯作者: Pandey,Ambarish