Global Health Research and Training in Cardiovascular Disease

心血管疾病的全球健康研究和培训

基本信息

批准号：
10655351
负责人：
Margaret Leighton McNairy
金额：
$ 12.42万
依托单位：
WEILL MEDICAL COLL OF CORNELL UNIV
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-07-01 至 2027-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10655351
关键词：
2019-nCoV Adult Amlodipine Antihypertensive Agents Area Blood Blood Pressure Blood Screening COVID-19 COVID-19 complications Cardiac Cardiac Death Cardiovascular Diseases Caring Case/Control Studies Cessation of life Clinic Clinical Clinical Investigator Clinical Trials Cohort Studies Communicable Diseases Communities Consumption Data Development Diabetes Mellitus Diastolic blood pressure Disease Early treatment Echocardiography Environment Event Faculty Family Fellowship Foundations Functional disorder Funding Future General Population Goals HIV Haiti Haitian Health Heart failure Hypertension Incidence Inflammation International Intervention Kidney Diseases Laboratories Lead Lead levels Leadership Learning Longitudinal cohort Mass Spectrum Analysis Mentors Mentorship Mid-Career Clinical Scientist Award (K24)Myocardial Infarction Myocardial dysfunction National Heart, Lung, and Blood Institute National Institute of Allergy and Infectious Disease Natural History Obesity Outcome Participant Persons Population Postdoctoral Fellow Poverty Prevalence Prevention Randomized Reach, Effectiveness, Adoption, Implementation, and Maintenance Recommendation Recording of previous events Research Research Project Grants Research Training Risk Factors Role Safety Serology Severities Site Smoking Sodium Sodium Chloride Source Spottings Stroke Tanzania Testing Time Training Training Programs Tuberculosis Unhealthy Diet United States Urine Woman biobank blood lead cardiovascular disorder epidemiology cardiovascular disorder risk clinical epidemiology clinical implementation cohort design early phase clinical trial environmental Pb exposure experience global health hypertension control hypertension treatment hypertensive immune activation implementation evaluation implementation science improved kidney dysfunction low income country medication compliance mortality occupational lead exposure patient oriented patient oriented research physical inactivity prehypertension premature primary outcome programs randomized trial randomized, clinical trials screening social determinants standard care stool sample training opportunity training project

项目摘要

ABSTRACT: The goals of this K24 proposal are to train clinical investigators in the conduct of patient-oriented cardiovascular disease (CVD) research primarily in Haiti, with a new project in Tanzania and to conduct a new study on environmental lead exposure and CVD risk factors in Haiti (Aim 1). The training also leverages four currently funded CVD research projects in Haiti (Aims 2-5), and a funded CVD research project in Tanzania (Aim 6). United States trainees will spend ~50-60% of their time at international research sites in Haiti and Tanzania, which have onsite Weill Cornell faculty, long-standing international collaborators, and outstanding environments for research training. The common theme of the projects is patient-oriented CVD research in the areas of clinical epidemiology, clinical trials, CVD-infectious diseases, and implementation science. The projects include: 1. Environmental lead exposure and CVD risk factors in Haiti 2. Clinical epidemiology of CVD risk factors, diseases, and poverty-related social determinants in Haiti 3. Randomized clinical trial of early hypertension treatment among persons living with HIV 4. COVID-19 and cardiac dysfunction 5. Implementation of hypertensive screening and management 6. Heart failure in Tanzania The focus of research training will be on postdoctoral clinical investigators who have completed their advanced degree training. Dr. McNairy has an impeccable history of excellence in research mentorship and serves in leadership roles in the Weill Cornell Global Health Research Fellowship and the Weill Cornell Women in Global Health Research Initiative. Trainees will be mentored by Dr. McNairy and will participate in research projects in Haiti (Aims 1-5) and Tanzania (Aim 6). These six projects have both clinical and laboratory aspects and offer trainees a broad research experience. Trainees learn through the conduct of their mentored research project and the opportunity to interact with colleagues working on studies other than their own. The K24 award will allow Dr. McNairy to decrease her administrative and clinical responsibilities and commit 50% effort to CVD- related research and mentorship of US trainees. Her long-term goal is to build a world-class CVD global health research and training program to improve CVD-related health outcomes among the world's poorest populations.

摘要：该 K24 提案的目标是培训临床研究人员进行以患者为导向的研究心血管疾病（CVD）研究主要在海地进行，在坦桑尼亚有一个新项目，并开展一项新的研究海地环境铅暴露和 CVD 风险因素研究（目标 1）。培训还利用了四个目前资助了海地的 CVD 研究项目（目标 2-5），以及坦桑尼亚资助的 CVD 研究项目（目标 6）。美国学员将花费大约 50-60% 的时间在海地和坦桑尼亚，拥有威尔康奈尔大学现场教师、长期国际合作者和杰出的研究培训环境。这些项目的共同主题是以患者为导向的 CVD 研究临床流行病学、临床试验、CVD 传染病和实施科学领域。这项目包括： 1. 海地的环境铅暴露和CVD危险因素 2. 海地CVD危险因素、疾病和与贫困相关的社会决定因素的临床流行病学 3. HIV感染者早期高血压治疗的随机临床试验 4. COVID-19和心脏功能障碍 5. 实施高血压筛查和管理 6. 坦桑尼亚的心力衰竭研究培训的重点将是完成高级研究的博士后临床研究人员学位培训。麦克奈里博士在研究指导方面有着无可挑剔的卓越历史，并在在威尔康奈尔全球健康研究奖学金和威尔康奈尔全球女性研究金中发挥领导作用健康研究倡议。学员将接受 McNairy 博士的指导，并参与以下领域的研究项目：海地（目标 1-5）和坦桑尼亚（目标 6）。这六个项目同时具有临床和实验室方面，并提供学员拥有广泛的研究经验。学员通过指导研究项目进行学习以及与从事其他研究的同事互动的机会。 K24奖将允许 McNairy 博士减少她的行政和临床职责，并将 50% 的精力投入到 CVD- 美国学员的相关研究和指导。她的长期目标是打造世界一流的CVD全球健康中心研究和培训计划旨在改善世界上最贫困人口与心血管疾病相关的健康状况人口。