Global Health Research and Training in Cardiovascular Disease

心血管疾病的全球健康研究和培训

基本信息

批准号：
10655351
负责人：
Margaret Leighton McNairy
金额：
$ 12.42万
依托单位：
WEILL MEDICAL COLL OF CORNELL UNIV
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-07-01 至 2027-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10655351
关键词：
2019-nCoV Adult Amlodipine Antihypertensive Agents Area Blood Blood Pressure Blood Screening COVID-19 COVID-19 complications Cardiac Cardiac Death Cardiovascular Diseases Caring Case/Control Studies Cessation of life Clinic Clinical Clinical Investigator Clinical Trials Cohort Studies Communicable Diseases Communities Consumption Data Development Diabetes Mellitus Diastolic blood pressure Disease Early treatment Echocardiography Environment Event Faculty Family Fellowship Foundations Functional disorder Funding Future General Population Goals HIV Haiti Haitian Health Heart failure Hypertension Incidence Inflammation International Intervention Kidney Diseases Laboratories Lead Lead levels Leadership Learning Longitudinal cohort Mass Spectrum Analysis Mentors Mentorship Mid-Career Clinical Scientist Award (K24)Myocardial Infarction Myocardial dysfunction National Heart, Lung, and Blood Institute National Institute of Allergy and Infectious Disease Natural History Obesity Outcome Participant Persons Population Postdoctoral Fellow Poverty Prevalence Prevention Randomized Reach, Effectiveness, Adoption, Implementation, and Maintenance Recommendation Recording of previous events Research Research Project Grants Research Training Risk Factors Role Safety Serology Severities Site Smoking Sodium Sodium Chloride Source Spottings Stroke Tanzania Testing Time Training Training Programs Tuberculosis Unhealthy Diet United States Urine Woman biobank blood lead cardiovascular disorder epidemiology cardiovascular disorder risk clinical epidemiology clinical implementation cohort design early phase clinical trial environmental Pb exposure experience global health hypertension control hypertension treatment hypertensive immune activation implementation evaluation implementation science improved kidney dysfunction low income country medication compliance mortality occupational lead exposure patient oriented patient oriented research physical inactivity prehypertension premature primary outcome programs randomized trial randomized, clinical trials screening social determinants standard care stool sample training opportunity training project

2019-nCoV Adult Amlodipine Antihypertensive Agents Area Blood Blood Pressure Blood Screening COVID-19 COVID-19 complications Cardiac Cardiac Death Cardiovascular Diseases Caring Case/Control Studies Cessation of life Clinic Clinical Clinical Investigator Clinical Trials Cohort Studies Communicable Diseases Communities Consumption Data Development Diabetes Mellitus Diastolic blood pressure Disease Early treatment Echocardiography Environment Event Faculty Family Fellowship Foundations Functional disorder Funding Future General Population Goals HIV Haiti Haitian Health Heart failure Hypertension Incidence Inflammation International Intervention Kidney Diseases Laboratories Lead Lead levels Leadership Learning Longitudinal cohort Mass Spectrum Analysis Mentors Mentorship Mid-Career Clinical Scientist Award (K24)Myocardial Infarction Myocardial dysfunction National Heart, Lung, and Blood Institute National Institute of Allergy and Infectious Disease Natural History Obesity Outcome Participant Persons Population Postdoctoral Fellow Poverty Prevalence Prevention Randomized Reach, Effectiveness, Adoption, Implementation, and Maintenance Recommendation Recording of previous events Research Research Project Grants Research Training Risk Factors Role Safety Serology Severities Site Smoking Sodium Sodium Chloride Source Spottings Stroke Tanzania Testing Time Training Training Programs Tuberculosis Unhealthy Diet United States Urine Woman biobank blood lead cardiovascular disorder epidemiology cardiovascular disorder risk clinical epidemiology clinical implementation cohort design early phase clinical trial environmental Pb exposure experience global health hypertension control hypertension treatment hypertensive immune activation implementation evaluation implementation science improved kidney dysfunction low income country medication compliance mortality occupational lead exposure patient oriented patient oriented research physical inactivity prehypertension premature primary outcome programs randomized trial randomized, clinical trials screening social determinants standard care stool sample training opportunity training project

展开

项目摘要

ABSTRACT: The goals of this K24 proposal are to train clinical investigators in the conduct of patient-oriented cardiovascular disease (CVD) research primarily in Haiti, with a new project in Tanzania and to conduct a new study on environmental lead exposure and CVD risk factors in Haiti (Aim 1). The training also leverages four currently funded CVD research projects in Haiti (Aims 2-5), and a funded CVD research project in Tanzania (Aim 6). United States trainees will spend ~50-60% of their time at international research sites in Haiti and Tanzania, which have onsite Weill Cornell faculty, long-standing international collaborators, and outstanding environments for research training. The common theme of the projects is patient-oriented CVD research in the areas of clinical epidemiology, clinical trials, CVD-infectious diseases, and implementation science. The projects include: 1. Environmental lead exposure and CVD risk factors in Haiti 2. Clinical epidemiology of CVD risk factors, diseases, and poverty-related social determinants in Haiti 3. Randomized clinical trial of early hypertension treatment among persons living with HIV 4. COVID-19 and cardiac dysfunction 5. Implementation of hypertensive screening and management 6. Heart failure in Tanzania The focus of research training will be on postdoctoral clinical investigators who have completed their advanced degree training. Dr. McNairy has an impeccable history of excellence in research mentorship and serves in leadership roles in the Weill Cornell Global Health Research Fellowship and the Weill Cornell Women in Global Health Research Initiative. Trainees will be mentored by Dr. McNairy and will participate in research projects in Haiti (Aims 1-5) and Tanzania (Aim 6). These six projects have both clinical and laboratory aspects and offer trainees a broad research experience. Trainees learn through the conduct of their mentored research project and the opportunity to interact with colleagues working on studies other than their own. The K24 award will allow Dr. McNairy to decrease her administrative and clinical responsibilities and commit 50% effort to CVD- related research and mentorship of US trainees. Her long-term goal is to build a world-class CVD global health research and training program to improve CVD-related health outcomes among the world's poorest populations.

摘要：该K24提案的目标是培训临床研究人员以患者为导向的心血管疾病（CVD）研究主要在海地，在坦桑尼亚进行了一个新项目，并进行了新的项目海地环境铅暴露和CVD风险因素的研究（AIM 1）。培训还利用四个目前在海地资助的CVD研究项目（AIMS 2-5），以及坦桑尼亚的资助CVD研究项目（目标6）。美国学员将在海地的国际研究地点花费约50-60％的时间坦桑尼亚（Tanzania 研究培训的环境。项目的共同主题是面向患者的CVD研究临床流行病学，临床试验，CVD感染性疾病和实施科学领域。这项目包括： 1。海地环境潜在客户暴露和CVD风险因素 2。CVD风险因素，疾病和与贫困相关的社会决定因素的临床流行病学 3。艾滋病毒患者早期高血压治疗的随机临床试验 4。COVID-19和心脏功能障碍 5。实施高血压筛查和管理 6。坦桑尼亚的心力衰竭研究培训的重点将放在已经完成高级的博士后临床研究人员身上学位培训。 McNairy博士拥有无可挑剔的研究指导历史，并在 Weill Cornell全球健康研究奖学金和Weill Cornell妇女在全球的领导角色健康研究计划。学员将由McNairy博士指导，并将参加研究项目海地（目标1-5）和坦桑尼亚（目标6）。这六个项目既有临床和实验室方面，并提供学员是广泛的研究经验。学员通过他们的指导研究项目的行为学习以及与自己从事研究以外的其他研究的同事互动的机会。 K24奖将允许McNairy博士降低她的行政和临床责任，并付出50％的努力来CVD- 美国学员的相关研究和指导。她的长期目标是建立世界一流的CVD全球健康研究与培训计划，以改善世界上最贫穷的CVD相关的健康成果人群。