A longitudinal cohort study to evaluate cardiovascular risk factors and disease in Haiti

评估海地心血管危险因素和疾病的纵向队列研究

基本信息

批准号：
10653445
负责人：
Margaret Leighton McNairy
金额：
$ 2.63万
依托单位：
WEILL MEDICAL COLL OF CORNELL UNIV
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-08-01 至 2023-08-24
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10653445
关键词：
AIDS prevention Acquired Immunodeficiency Syndrome Address Adult Age of Onset Biological Black American Cardiac Death Cardiovascular Diseases Cholera Chronic Disease Clinical Clinical Research Clinical Trials Cohort Studies Collaborations Data Diabetes Mellitus Disease Dyslipidemias Enrollment Epidemic Event Feces Future Goals HIV HIV Infections Haiti Haitian Health Heart failure Hypertension Immigrant Incidence Individual Infection Inflammation Intervention Kidney Diseases Knowledge Longitudinal cohort Longitudinal cohort study Measures Mental Depression Myocardial Infarction Natural History Obesity Outcome Persons Pilot Projects Plasma Population Poverty Prevalence Prevention Prevention strategy Public Health Reporting Reproductive Health Research Research Infrastructure Risk Factors Role Saliva Sampling Sanitation Serum Smoking Social isolation Stress Stroke Time Translating Tuberculosis Unhealthy Diet United States United States National Institutes of Health Universities Urine Whole Blood aged antiretroviral therapy biobank cardiovascular disorder epidemiology cardiovascular disorder risk cardiovascular risk factor cigarette smoking cohort combat design early onset environmental Pb exposure epidemiology study fighting follow-up food insecurity improved insight lead exposure mortality novel nutrition physical inactivity population based prevent psychologic response social social determinants treatment strategy young adult

项目摘要

ABSTRACT: Cardiovascular disease (CVD) is now the leading cause of mortality in Haitian adults. Our preliminary data suggest that hypertension is the single most important CVD risk factor in Haiti and may be driven by poverty-related social and environmental determinants. However, the prevalence, incidence, major risk factors, and social and environmental determinants are unknown. Longitudinal cohort studies are urgently needed to address these knowledge gaps in order to develop interventions to prevent CVD and improve health outcomes of Haitians in both Haiti and in the United States. We propose to fill this gap by establishing the first longitudinal cohort to study the natural history of CVD in Haiti. The cohort will include 3,000 adults >18 years in Port-au-Prince using multistage random sampling, and follow them for 2 to 3.5 years depending on the timing of study enrollment. We anticipate that hypertension prevalence will be ≥10% in 18-30 year olds, that hypertension incidence will be >10 events/1000 person years, and that both prevalent and incident hypertension will be associated with poverty-related social and environmental determinants. We will also examine the association of determinants and risk factors with CVD. We will biobank whole blood, serum, plasma, saliva, stool, and urine samples for future studies. Our Specific Aims are to: 1. Establish a population-based cohort of 3,000 adults in Port-au-Prince and assess the prevalence of CVD risk factors and diseases and their association with social and environmental determinants. a. Cardiovascular risk factors include hypertension, diabetes, obesity, dyslipidemia, kidney disease, poor diet, cigarette smoking, physical inactivity, and inflammation. b. Cardiovascular diseases include myocardial infarction, heart failure, stroke, and CVD mortality. c. Determinants include stress, social isolation, depression, food insecurity, and lead exposure. 2. Determine the incidence of CVD risk factors and diseases and their association with social and environmental determinants. This study will provide important insights into the epidemiology of CVD in Haiti. The study also builds a platform for future research by establishing a population-based cohort, collecting data on other important chronic diseases in Haiti (e.g. diabetes, renal disease), creating a biobank, and using measures and outcomes that are directly comparable to existing US CVD cohorts. Our ultimate goal is to translate new research findings from this study into pragmatic prevention and treatment interventions to fight the CVD epidemic in Haiti and in Haitian immigrants in the US.

摘要：心血管疾病 (CVD) 目前是海地成年人死亡的主要原因。初步数据表明，高血压是海地最重要的 CVD 危险因素，并且可能是然而，贫困的发生率、发生率、主要因素是由与贫困相关的社会和环境决定因素驱动的。风险因素以及社会和环境决定因素尚不清楚。需要弥补这些知识差距，以便制定预防心血管疾病和改善健康的干预措施海地人在海地和美国的成果。我们建议通过建立第一个纵向队列来研究 CVD 的自然史来填补这一空白。海地该队列将包括太子港 3,000 名 18 岁以上的成年人，采用多阶段随机抽样，以及根据研究入组的时间，我们预计高血压会持续 2 至 3.5 年。 18-30岁人群患病率≥10%，高血压发病率>10次/1000人年，高血压的患病率和发病率都与贫困相关的社会和我们还将研究环境决定因素和风险因素与 CVD 的关联。我们将对全血、血清、血浆、唾液、粪便和尿液样本进行生物样本库，以供未来研究之用。我们的具体目标是： 1. 在太子港建立一个由 3,000 名成年人组成的人群队列，并评估以下疾病的患病率： CVD 危险因素和疾病及其与社会和环境决定因素的关联。 a. 心血管危险因素包括高血压、糖尿病、肥胖、血脂异常、肾病、贫困饮食、吸烟、缺乏运动和炎症。 b. 心血管疾病包括心肌梗塞、心力衰竭、中风和CVD死亡率。 c. 决定因素包括压力、社会孤立、抑郁、食品不安全和铅暴露。 2. 确定CVD危险因素和疾病的发生率及其与社会和文化的关系环境决定因素。这项研究将为海地的 CVD 流行病学提供重要见解。通过建立基于人群的队列、收集其他重要的数据来为未来的研究提供平台海地的慢性病（例如糖尿病、肾病），创建生物库，并采取措施和我们的最终目标是转化新的结果，与美国现有的 CVD 队列直接比较。这项研究的研究结果涉及对抗心血管疾病的务实预防和治疗干预措施该流行病在海地和美国的海地移民中流行。