Neurocognitive mechanisms of reward - motivated memory persistence across age

奖励驱动的跨年龄记忆持久性的神经认知机制

• 批准号: 10662100
• 负责人: Alexandra Cohen
• 金额: $ 11.79万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-08-01 至 2027-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10662100
• 关键词: Address; Adolescence; Adolescent; Adult; Affect; Affective; Age; Behavior; Behavioral; Brain; Child; Child Abuse; Childhood; Cognitive; Computer Models; Consummatory Behavior; Corpus striatum structure; Data; Decision Making; Dependence; Desire for food; Development; Development Plans; Dopamine; Ecological momentary assessment; Exhibits; Foundations; Functional Magnetic Resonance Imaging; Future; Goals; Hippocampus (Brain); Hour; Image; Intervention; Knowledge; Lead; Learning; Link; Maintenance; Measures; Memory; Methodology; Methods; Modeling; Motivation; Multivariate Analysis; Neurocognitive; Neuronal Plasticity; Neurosciences Research; Outcome; Participant; Patient Self-Report; Pattern; Physical activity; Predisposition; Psychological reinforcement; Research; Research Project Grants; Research Training; Rest; Retrieval; Rewards; Risk; Risk Behaviors; Risk-Taking; Rodent; Severity of illness; Shapes; Signal Transduction; Sleep; Stimulus; Substance Use Disorder; Substance abuse problem; System; Thinking; Training; Translating; Ventral Tegmental Area; Work; addiction; age related; behavior influence; career; career development; cognitive neuroscience; experience; high reward; insight; knowledge base; memory encoding; memory process; memory retrieval; mesolimbic system; motivated behavior; neuroimaging; neuromechanism; novel; relating to nervous system; skills; stem; substance use; substance use prevention; translational approach

Project Summary/Abstract My career goal is to a lead a research group that investigates the neurocognitive development of motivationally-salient memory formation and how persistent memories influence behaviors that can increase risk for substance use disorders. To acquire the necessary skills to lead a team pursuing this line of research, I propose a project that aims to examine the neural mechanisms underlying reward-motivated memory, the influence of previously learned reward value on new learning, and the impact of real-world positive affect states on memory processes from childhood to adulthood. My training to date has provided me with a strong methodological and theoretical foundation in developmental cognitive neuroscience and basic behavioral neuroscience research. My career development plan builds on this knowledge base by providing crucial, intensive training in the study of reward-motivated memory and its relation to addiction, multivariate analyses of neuroimaging data, computational modeling, and ecological momentary assessment methods. Completion of the proposed research and training will prepare me to lead a lab that uses a translational approach to study appetitive and aversive motivated memory processes and how they guide future behaviors across development, using sophisticated computational and neuroimaging approaches. Research Project: Experimentation with addictive substances often begins during adolescence, increasing the risk of progression to addiction. Normative developmental changes in mesolimbic dopamine systems, which drive adolescent reward sensitivity and motivated behaviors, alongside changes in hippocampal memory systems may yield vulnerability to substance abuse during adolescence. While a rich body of research has focused on how reward sensitivity drives reactive and consummatory behaviors during adolescence, few studies have investigated how this sensitivity shapes memory and future choices. The goal of the proposed research is to investigate age-related changes in reward-motivated memory persistence that may contribute to substance abuse from childhood to adulthood, spanning the transition into and out of adolescence. We hypothesize that adolescent reward sensitivity enhances the persistence of reward-motivated memories, yielding greater susceptibility to substance abuse. The first study (Aim 1) will identify age-related changes in the neural mechanisms supporting reward-motivated memories. The second study (Aim 2) will determine how reward-motivated experiences and related brain activity influence subsequent learning across age. Finally, the third study will investigate how real-world affective states influence memory and its relation to substance use across age (Aim 3). Understanding the neurocognitive mechanisms through which rewards modulate memory and guide future behaviors across age – both in the lab and in the real-world – may provide key insights into how to help prevent substance use disorders and to promote a healthy transition into adulthood.

项目概要/摘要 我的职业目标是领导一个研究小组，研究神经认知发展 动机显着的记忆形成以及持久记忆如何影响可以增加的行为 为了获得领导团队进行这一研究的必要技能，我 一个旨在研究奖励驱动记忆背后的神经机制的项目 先前学到的奖励值对新学习的影响，以及现实世界积极情感状态的影响 迄今为止，我对从童年到成年的记忆过程的训练为我提供了强大的力量。 发展认知神经科学和基本行为的方法论和理论基础 我的职业发展计划建立在这个知识基础上，提供重要的、 奖励动机记忆及其与成瘾关系研究的强化训练，多变量分析 神经影像数据、计算模型和生态瞬时评估方法。 拟议的研究和培训将使我准备好领导一个使用转化方法进行研究的实验室 食欲和厌恶动机的记忆过程以及它们如何指导未来的行为 使用复杂的计算和神经成像方法进行开发。 研究项目：成瘾物质的实验通常在青春期开始， 增加中脑边缘多巴胺的正常发育变化的风险。 系统，它驱动青少年奖励敏感性和动机行为，以及变化 海马体记忆系统可能在青春期容易遭受药物滥用。 研究主体集中于奖励敏感性如何驱动反应和完成行为 在青春期，很少有研究调查这种敏感性如何影响记忆和未来的选择。 拟议研究的目的是调查奖励驱动的记忆持久性与年龄相关的变化 可能会导致从童年到成年的药物滥用，跨越进入和退出的过渡 我们发现青少年的奖励敏感性增强了奖励动机的持久性。 第一项研究（目标 1）将确定与年龄相关的情况。 第二项研究（目标 2）将支持奖励驱动记忆的神经机制发生变化。 确定奖励驱动的经历和相关的大脑活动如何影响随后的学习 最后，第三项研究将调查现实世界的情感状态如何影响记忆及其与年龄的关系。 跨年龄层的物质使用（目标 3）。 调节记忆并指导跨年龄段的未来行为——无论是在实验室还是在现实世界中——可能会提供 关于如何帮助预防物质使用障碍和促进健康过渡的关键见解 成年期。