Neurocognitive mechanisms of reward - motivated memory persistence across age

奖励驱动的跨年龄记忆持久性的神经认知机制

• 批准号: 10662100
• 负责人: Alexandra Cohen
• 金额: $ 11.79万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-08-01 至 2027-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10662100
• 关键词: Address; Adolescence; Adolescent; Adult; Affect; Affective; Age; Behavior; Behavioral; Brain; Child; Child Abuse; Childhood; Cognitive; Computer Models; Consummatory Behavior; Corpus striatum structure; Data; Decision Making; Dependence; Desire for food; Development; Development Plans; Dopamine; Ecological momentary assessment; Exhibits; Foundations; Functional Magnetic Resonance Imaging; Future; Goals; Hippocampus (Brain); Hour; Image; Intervention; Knowledge; Lead; Learning; Link; Maintenance; Measures; Memory; Methodology; Methods; Modeling; Motivation; Multivariate Analysis; Neurocognitive; Neuronal Plasticity; Neurosciences Research; Outcome; Participant; Patient Self-Report; Pattern; Physical activity; Predisposition; Psychological reinforcement; Research; Research Project Grants; Research Training; Rest; Retrieval; Rewards; Risk; Risk Behaviors; Risk-Taking; Rodent; Severity of illness; Shapes; Signal Transduction; Sleep; Stimulus; Substance Use Disorder; Substance abuse problem; System; Thinking; Training; Translating; Ventral Tegmental Area; Work; addiction; age related; behavior influence; career; career development; cognitive neuroscience; experience; high reward; insight; knowledge base; memory encoding; memory process; memory retrieval; mesolimbic system; motivated behavior; neuroimaging; neuromechanism; novel; relating to nervous system; skills; stem; substance use; substance use prevention; translational approach

Project Summary/Abstract My career goal is to a lead a research group that investigates the neurocognitive development of motivationally-salient memory formation and how persistent memories influence behaviors that can increase risk for substance use disorders. To acquire the necessary skills to lead a team pursuing this line of research, I propose a project that aims to examine the neural mechanisms underlying reward-motivated memory, the influence of previously learned reward value on new learning, and the impact of real-world positive affect states on memory processes from childhood to adulthood. My training to date has provided me with a strong methodological and theoretical foundation in developmental cognitive neuroscience and basic behavioral neuroscience research. My career development plan builds on this knowledge base by providing crucial, intensive training in the study of reward-motivated memory and its relation to addiction, multivariate analyses of neuroimaging data, computational modeling, and ecological momentary assessment methods. Completion of the proposed research and training will prepare me to lead a lab that uses a translational approach to study appetitive and aversive motivated memory processes and how they guide future behaviors across development, using sophisticated computational and neuroimaging approaches. Research Project: Experimentation with addictive substances often begins during adolescence, increasing the risk of progression to addiction. Normative developmental changes in mesolimbic dopamine systems, which drive adolescent reward sensitivity and motivated behaviors, alongside changes in hippocampal memory systems may yield vulnerability to substance abuse during adolescence. While a rich body of research has focused on how reward sensitivity drives reactive and consummatory behaviors during adolescence, few studies have investigated how this sensitivity shapes memory and future choices. The goal of the proposed research is to investigate age-related changes in reward-motivated memory persistence that may contribute to substance abuse from childhood to adulthood, spanning the transition into and out of adolescence. We hypothesize that adolescent reward sensitivity enhances the persistence of reward-motivated memories, yielding greater susceptibility to substance abuse. The first study (Aim 1) will identify age-related changes in the neural mechanisms supporting reward-motivated memories. The second study (Aim 2) will determine how reward-motivated experiences and related brain activity influence subsequent learning across age. Finally, the third study will investigate how real-world affective states influence memory and its relation to substance use across age (Aim 3). Understanding the neurocognitive mechanisms through which rewards modulate memory and guide future behaviors across age – both in the lab and in the real-world – may provide key insights into how to help prevent substance use disorders and to promote a healthy transition into adulthood.

项目摘要/摘要 我的职业目标是领导一个研究研究小组的研究小组 以动机为单位的记忆形成以及持续的记忆如何影响可以增加的行为 药物使用障碍的风险。为了获得领导一支追求这一研究的团队的必要技能，我 提案一个旨在检查奖励动机记忆的神经力学的项目， 以前学习的奖励价值对新学习的影响以及现实世界积极影响状态的影响 从童年到成年的记忆过程。迄今为止，我的培训为我提供了强大的 发展性认知神经科学和基本行为的方法论和理论基础 神经科学研究。我的职业发展计划是通过提供关键的知识基础建立的 在研究奖励动机记忆研究及其与成瘾的关系中进行的深入培训，多变量分析 神经影像学数据，计算建模和生态瞬时评估方法。完成 拟议的研究和培训将使我为使用翻译方法研究的实验室做好准备 开胃和厌恶动机的记忆过程以及它们如何指导未来的行为 开发，使用复杂的计算和神经影像学方法。 研究项目：对添加剂物质的实验通常在青少年期间开始 增加成瘾的风险。中唇多巴胺的规范性发展变化 促进青少年奖励灵敏度和融合行为的系统，以及变化 海马记忆系统可能会在青少年期间引起滥用药物滥用的脆弱性。虽然有钱 研究团体的重点是奖励灵敏度如何驱动反应性和完整行为 青少年，很少有研究研究这种敏感性如何塑造记忆和未来选择。目标 拟议的研究是调查与年龄相关的奖励动机记忆持久性变化 可能会导致从童年到成年的药物滥用 青春期的分数。我们假设青少年奖励敏感性增强了奖励动机的持久性 记忆，对药物滥用产生更大的敏感性。第一项研究（AIM 1）将确定与年龄有关的 支持奖励动机记忆的神经机制的变化。第二项研究（AIM 2）将 确定奖励动机的体验和相关的大脑活动如何影响随后的学习 年龄。最后，第三项研究将研究现实世界情感状态如何影响记忆及其与之的关系 跨年龄的物质使用（AIM 3）。了解奖励的神经认知机制 在实验室和现实世界中，调节记忆并指导整个年龄的未来行为 - 可能会提供 关于如何帮助防止药物使用障碍的关键见解，并促进健康过渡到 成年。