Training in Cellular & Molecular Biology

蜂窝培训

• 批准号: 10654830
• 负责人: Andrew Atwell Oberst
• 金额: $ 95.98万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-07-01 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10654830
• 关键词: Cellular biology; Molecular Biology; Training

Abstract The Cellular and Molecular Biology (CMB) training program offers doctoral candidates a multidisciplinary education in molecular and cellular biology at institutions located within the Seattle biomedical corridor. Administered out of the University of Washington (UW), this interdisciplinary program also supports predoctoral trainees at the Fred Hutchinson Cancer Research Center (Fred Hutch) and partner institutions. The primary objectives of the CMB program are to recruit a diverse group of enthusiastic and motivated students who are passionate about the biomedical sciences and to provide personalized training across a range of disciplines pertaining to basic and translational aspects of molecular and cellular biology. These talented individuals have the opportunity to be mentored by 63 faculty members who are experts in a range of disciplines. Students are drawn from seven participating graduate programs that include Biochemistry, Genome Sciences, Immunology, Microbiology, Molecular and Cellular Biology, Neuroscience, and Pharmacology. CMB trainees enter the program in Year 2 of graduate school after holistic selection through written and oral components of the annual application competition. Trainees complete mandatory coursework in biostatistics and fundamentals of molecular biology; participate in the Biomedical Research Integrity Lecture series; attend a monthly student organized research conference with speaking and networking opportunities; receive training in scientific rigor and reproducibility, gain scientific writing skills, participate in a peer mentoring program and take part in the annual CMB Training Grant retreat. Traditionally, the CMB program has successfully partnered with several minority advocacy groups to promote diversity on all campuses. We continue to expand the under-represented minority (URM) footprint and are now additionally emphasizing the recruitment and retention of students who are the first in their families to attend college (first generation) and students with disabilities. This innovative graduate training environment encourages trainees to pursue scientific excellence and endorses peer mentorship and the exploration of alternative career paths. The intended outcome is to nurture a diverse close-knit group of students who are equipped to become the next generation of scientific leaders.

抽象的 细胞和分子生物学（CMB）培训计划为博士生提供多学科的培训 在西雅图生物医学走廊内的机构进行分子和细胞生物学教育。 这个跨学科项目由华盛顿大学 (UW) 管理，还支持博士前课程 弗雷德·哈钦森癌症研究中心 (Fred Hutch) 和合作机构的实习生。初级 CMB 项目的目标是招募一群充满热情和积极进取的多元化学生，他们 对生物医学科学充满热情，并提供跨学科的个性化培训 有关分子和细胞生物学的基础和转化方面。这些才华横溢的人有 有机会接受 63 名各学科专家的教员的指导。学生们是 来自七个参与的研究生项目，包括生物化学、基因组科学、免疫学、 微生物学、分子和细胞生物学、神经科学和药理学。 CMB学员进入 通过年度书面和口头部分的整体选择后，研究生院第二年的课程 应用竞赛。学员完成生物统计学和基础知识的必修课程 分子生物学；参加生物医学研究诚信讲座系列；参加每月一次的学生 组织研究会议，提供演讲和交流机会；接受科学严谨的培训 和可重复性，获得科学写作技能，参加同行指导计划并参加 年度 CMB 培训补助金静修会。传统上，CMB 计划已与多家公司成功合作 少数群体倡导团体促进所有校园的多样性。我们继续扩大代表性不足的群体 少数族裔（URM）的足迹，现在还额外强调招募和保留少数族裔学生 家庭中第一个上大学的人（第一代）和残疾学生。这位富有创新精神的毕业生 培训环境鼓励受训者追求科学卓越，并支持同行指导和 探索替代职业道路。预期的结果是培养一个多元化、紧密团结的学生群体 他们有能力成为下一代科学领袖。

项目成果

Mass Spectrometry Identification of Biomarkers in Extracellular Vesicles From Plasmodium vivax Liver Hypnozoite Infections.

• DOI: 10.1016/j.mcpro.2022.100406
• 发表时间: 2022-10
• 期刊: MOLECULAR & CELLULAR PROTEOMICS
• 影响因子: 7
• 作者: Gualdron-Lopez, Melisa;Diaz-Varela, Miriam;Zanghi, Gigliola;Aparici-Herraiz, Iris;Steel, Ryan W. J.;Schafer, Carola;Cusco, Pol;Chuenchob, Vorada;Kangwangransan, Niwat;Billman, Zachary P.;Olsen, Tayla M.;Gonzalez, Juan R.;Roobsoong, Wanlapa;Sattabongkot, Jetsumon;Murphy, Sean C.;Mikolajczak, Sebastian A.;Borras, Eva;Sabido, Eduard;Fernandez-Becerra, Carmen;Flannery, Erika L.;Kappe, Stefan H., I;del Portillo, Hernando A.
• 通讯作者: del Portillo, Hernando A.

Conserved and Taxon-Specific Patterns of Phenotypic Modularity in the Mammalian Dentition.

• DOI: 10.1093/iob/obac017
• 发表时间: 2022
• 期刊: INTEGRATIVE ORGANISMAL BIOLOGY
• 影响因子: 1.5
• 作者: Takenaka, Risa;Clay, Selene M.;Yoo, Sunwoo;Hlusko, Leslea J.
• 通讯作者: Hlusko, Leslea J.

Stalled but not forgotten: Bacterial exotoxins inhibit translation to activate NLRP1.

停滞但未被遗忘：细菌外毒素抑制翻译以激活 NLRP1。

• DOI: 10.1084/jem.20231160
• 发表时间: 2023
• 期刊: The Journal of experimental medicine
• 作者: Tibble,Ryan;Yonemitsu,MarisaA;Mitchell,PatrickS
• 通讯作者: Mitchell,PatrickS

Longitudinal TprK profiling of in vivo and in vitro-propagated Treponema pallidum subsp. pallidum reveals accumulation of antigenic variants in absence of immune pressure.

• DOI: 10.1371/journal.pntd.0009753
• 发表时间: 2021-09
• 期刊: PLoS neglected tropical diseases
• 影响因子: 3.8
• 作者: Lin MJ;Haynes AM;Addetia A;Lieberman NAP;Phung Q;Xie H;Nguyen TV;Molini BJ;Lukehart SA;Giacani L;Greninger AL
• 通讯作者: Greninger AL

Plasmodium vivax latent liver infection is characterized by persistent hypnozoites, hypnozoite-derived schizonts, and time-dependent efficacy of primaquine.

• DOI: 10.1016/j.omtm.2022.07.016
• 发表时间: 2022-09-08
• 期刊: MOLECULAR THERAPY METHODS & CLINICAL DEVELOPMENT
• 作者: Flannery, Erika L.;Kangwanrangsan, Niwat;Chuenchob, Vorada;Roobsoong, Wanlapa;Fishbaugher, Matthew;Zhou, Kevin;Billman, Zachary P.;Martinson, Thomas;Olsen, Tayla M.;Schaefer, Carola;Campo, Brice;Murphy, Sean C.;Mikolajczak, Sebastian A.;Kappe, Stefan H. I.;Sattabongkot, Jetsumon
• 通讯作者: Sattabongkot, Jetsumon