Genetic modifiers of the Mediterranean-DASH diet Intervention for Neurodegenerative Delay (MIND) response

地中海 DASH 饮食的基因修饰神经退行性延迟 (MIND) 反应干预

基本信息

批准号：
10402905
负责人：
Marilyn C Cornelis
金额：
$ 54.02万
依托单位：
NORTHWESTERN UNIVERSITY AT CHICAGO
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-09-15 至 2025-04-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10402905
关键词：
Adherence Affect Age-Years Age-associated memory impairment Aging Alzheimer&apos s Disease Alzheimer&apos s disease risk Alzheimer’s disease biomarker Amyloid Animals Autopsy Berry Biological Brain Brain-Derived Neurotrophic Factor Carotenoids Characteristics Cholesterol Cholesterol Homeostasis Clinical Cognitive Communities Complex Consumption DASH diet Data Dementia Diet Dietary Fiber Dietary Intervention Dietary Practices Disease Disease susceptibility Domestic Fowls Effectiveness Environmental Risk Factor Epidemiology Folic Acid Food Genes Genetic Genotype Health Immune Targeting Immune response Immunity Impaired cognition Impairment Individual Inflammation Intake Interleukin-6 Intervention Knowledge Literature Magnetic Resonance Imaging Measures Mediating Metabolism Nerve Degeneration Nutrient Nuts Olive oil preparation Participant Pathologic Pathway interactions Patient Self-Report Persons Play Population Predisposition Preventive measure Prospective Studies Research Risk Role Seafood Single Nucleotide Polymorphism Structure Subgroup Symptoms Unsaturated Fatty Acids Variant Vegetables Vitamin E Vitamin K Wine Woman base bean circulating biomarkers cognitive change epidemiologic data folic acid metabolism genetic information genome wide association study glucose metabolism indexing individual variation insight men mild cognitive impairment neuropathology nutrient metabolism polyphenol population based preventive intervention response saturated fat tool vitamin metabolism

项目摘要

ABSTRACT Age-associated cognitive decline varies in extent among individuals, and this variation likely arises from a complex interplay of genetic and environmental factors. The Mediterranean-DASH Diet Intervention for Neurodegenerative Delay (MIND) is based on the most compelling evidence in the diet-dementia field. Epidemiological data suggest that greater adherence to the MIND diet slows the rate of cognitive decline and reduces the risk of Alzheimer's disease (AD). Genome-wide association studies of AD are enriched with variants mapping to genes implicated in immune response and cholesterol metabolism, which may result in different responses to preventive measures such as diet. Foods and nutrients emphasized by MIND have also been shown to have beneficial effects on the brain, potentially mediated by immunity or cholesterol pathways. Genetic factors contributing to between-person variation in metabolism of key MIND components may also enhance or limit their efficacy and ultimately impact response to this diet. MIND associations with cognitive health are modest overall but, when combined with individual genetic information concerning AD susceptibility and MIND-component metabolism, may reveal subgroups of the population who especially benefit when adhering to this diet. Our proposal leverages the first, ongoing MIND trial as well as existing community- and population-based data to examine how genetic differences in (a) AD predisposition and (b) nutrient metabolism modify the response to the MIND diet. Our research will provide mechanistic insights into the role that MIND may play in slowing cognitive decline and will also inform the implementation of MIND for optimal effectiveness.

抽象的年龄相关的认知下降在个体之间的程度上有所不同，这种差异可能来自遗传和环境因素的复杂相互作用。地中海 - 划线饮食干预神经退行性延迟（思维）是基于饮食降解领域中最引人注目的证据。流行病学数据表明，对思维饮食的依从性更大会减慢认知能力下降的速度和降低了阿尔茨海默氏病（AD）的风险。全基因组关联研究富含映射到与免疫反应和胆固醇代谢有关的基因的映射，这可能导致对饮食等预防措施的反应不同。心灵强调的食物和营养也被证明对大脑具有有益的作用，可能是由免疫或胆固醇途径介导的。遗传因素导致关键思维成分代谢中间变化的遗传因素也可能增强或限制其功效，并最终影响对这种饮食的反应。与认知健康的思维联系总体上是适中的，但是与个体遗传结合在一起时有关广告敏感性和思维成分代谢的信息可能揭示遵守这种饮食时特别受益的人口。我们的建议利用了第一个持续的思想试验以及现有的社区和基于人群的数据，以研究（a）广告中的遗传差异易感性和（b）营养代谢改变了对思维饮食的反应。我们的研究将提供对思维在减慢认知能力下降中可能扮演的作用的机械洞察力，也将为实施思维以获得最佳有效性。