Trigeminal nociceptors: Neural intersection of chronic pain and alveolar bone remodeling

三叉神经伤害感受器：慢性疼痛和牙槽骨重塑的神经交叉

基本信息

批准号：
10645196
负责人：
Man-Kyo Chung
金额：
$ 102.92万
依托单位：
UNIVERSITY OF MARYLAND BALTIMORE
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-09-08 至 2028-06-30
项目状态：
未结题

项目摘要

Orofacial tissues are richly innervated by nociceptive primary afferents (or nociceptors). Nociceptors transmit pain signals into brain in response to harmful stimuli. Nociceptors also intricately regulate homeostasis of innervated tissues by controlling host responses. Under injury or infection, dysfunctional nociceptors lead to the development of pathological chronic pain and abnormal destructive responses of affected tissues. Dr. Chung’s unique R35 program addresses dual roles of trigeminal nociceptors in two fundamental areas in oral health. Dr. Chung is a dentist scientist, who has devoted his career to craniofacial neuroscience research focused on trigeminal nociceptors. He will continue his ongoing craniofacial pain studies by testing the hypothesis that long-term silencing of nociceptive afferents is analgesic, and that the effects are sufficient to reverse maladaptive neuroplastic changes of brain regions associated with chronic pain. Moreover, Dr. Chung is revisiting his long-term interest in tooth-related neurobiology, and will investigate the neuroimmune and neuroskeletal regulatory mechanisms of alveolar bone destruction and remodeling. He hypothesizes that nociceptive afferents regulate periodontal host responses under periodontal infection or orthodontic force to control pathophysiological remodeling of alveolar bone. Dr. Chung’s research in these areas is aimed at elucidating the mechanisms of chronic pain and alveolar bone remodeling, and their intersection with trigeminal nociceptors. The anticipated outcomes will likely have significant impact, not only in elucidating basic mechanisms but also in translational areas including development of novel methods to control chronic pain and alveolar bone remodeling by regulating nociceptive afferents or nociceptor-enriched molecules.

口面组织通过伤害感受的原发性传入（或伤害感受器）来支配。伤害感受器会发射响应有害刺激的疼痛信号进入大脑。伤害感受器还错综复杂地调节了通过控制宿主反应来支配组织。在受伤或感染下，功能失调的伤害感受器导致病理慢性疼痛和受影响组织的破坏性反应异常的发展。博士 Chung独特的R35计划解决了口头两个基本区域中三叉神经摄影师的双重角色健康。 Chung博士是一位牙医科学家，他的职业生涯致力于颅面神经科学研究专注于三叉神经感受器。他将通过测试假设伤害性传入的长期沉默是镇痛的，并且影响足以使与慢性疼痛相关的大脑区域的反向不良的神经塑性变化。而且，钟博士正在重新审视他对牙齿相关神经生物学的长期兴趣，并将调查神经免疫性和肺泡骨破坏和重塑的神经骨骼调节机制。他假设这一点伤害性传入调节牙周感染或正畸力下的牙周宿主反应控制肺泡骨的病理生理重塑。 Chung博士在这些领域的研究针对阐明慢性疼痛和肺泡骨重塑的机制，并与三叉神经相交伤害感受器。预期的结果可能会产生重大影响，不仅在阐明基本的方面机制，但在转化领域，包括开发用于控制慢性疼痛和的新方法通过控制伤害感受传入剂或富含伤害感受器的分子来重塑牙槽骨。