Pharmaceutical Sciences and Pharmacogenomics

药物科学和药物基因组学

• 批准号: 10652249
• 负责人: Nadav Ahituv
• 金额: $ 48.62万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-07-01 至 2027-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10652249
• 关键词: Pharmacogenomics; Pharmacologic Substance; Science

PROJECT SUMMARY The Pharmaceutical Sciences and Pharmacogenomics (PSPG) Graduate Program is a unique, dynamic, contemporary program in pharmaceutical sciences and pharmacogenomics at the University of California San Francisco that attracts diverse faculty and students who share a common interest in applying basic sciences to challenging research topics in drug development and precision drug therapy. The graduate program reflects exciting scientific developments in the area of genomics, quantitative and systems pharmacology, therapeutics and computation that have far-reaching implications to the pharmaceutical and pharmacological sciences. The goal of the PSPG graduate program is to educate and train Ph.D. students to conceptualize, design and execute innovative scientific research in the interdisciplinary scientific areas encompassed by modern pharmaceutical sciences. The program brings together 66 well-funded faculty members spanning 17 departments. This multidisciplinary and unique graduate program has a dual focus: 1) pharmaceutical sciences and drug development, including molecular and systems pharmacology, drug delivery and therapeutic bioengineering, gene therapy and pharmacokinetics/pharmacodynamics and modeling; and 2) pharmacogenomics, the application of genetics and genomics for the development of novel therapeutics and the optimal use of drugs in individual patients for precision medicine. The training program includes a series of core courses providing an in-depth understanding of the principles of pharmaceutical sciences and pharmacogenomics, including an innovative new core course in systems pharmacology. Core courses are complemented by electives covering advanced drug delivery and pharmacokinetic principles, principles of genetics and cell biology, bioinformatics, tissue and organ biology, CRISPR therapeutics and computer programming. Students also participate in laboratory rotations that expose them to the diversity of potential projects available for their dissertation research and a university-wide course on responsible conduct of research. The program immerses trainees in the culture of science through a journal club with students across four basic science graduate programs that are focused on quantitative approaches to studying biology, a seminar program which brings in leading academic, regulatory and industrial scientists, student research presentations, and an annual retreat. The program goal is to recruit 8- 12 outstanding Ph.D. students per year, plus at least one student for a combined Pharm.D./Ph.D. degree. Underrepresented minority students are actively recruited through a number of faculty activities and represent 20% of our students. Upon graduation, the new PSPG Ph.D. scientist will have the ethics, knowledge and tools necessary to become independent researchers, and also the passion and enthusiasm to make impactful contributions to the pharmaceutical sciences and pharmacogenomics field throughout their career.

项目摘要 药物科学与药物基因组学（PSPG）研究生课程是一个独特的，动态的， 加利福尼亚大学SAN的药物科学与药物基因组学的当代课程 弗朗西斯科（Francisco 挑战药物开发和精确药物治疗方面的研究主题。研究生课程反映 基因组学，定量和系统药理学，治疗学领域令人兴奋的科学发展 以及对药物和药理学科学具有深远影响的计算。这 PSPG研究生课程的目标是教育和培训博士学位。学生概念化，设计和执行 现代药品所包含的跨学科科学领域的创新科学研究 科学。该计划汇集了66名资助良好的教职员工，跨越了17个部门。这 多学科和独特的研究生课程具有双重重点：1）药物和药物 开发，包括分子和系统药理学，药物输送和治疗生物工程， 基因治疗和药代动力学/药效学和建模； 2）药物基因组学， 遗传学和基因组学用于开发新的治疗剂，并最佳使用药物 个人患者的精确药物。培训计划包括一系列核心课程，提供 对药物和药物基因组学原理的深入了解，包括 创新的系统药理学新核心课程。核心课程由选修课补充 先进的药物输送和药代动力学原理，遗传学和细胞生物学原理，生物信息学， 组织和器官生物学，CRISPR疗法和计算机编程。学生也参加 实验室轮换使他们暴露于他们的论文研究的潜在项目的多样性 以及负责研究的大学范围内的课程。该计划使学员沉浸在文化中 通过期刊俱乐部与四个基础科学研究生课程的学生一起进行科学俱乐部 关于研究生物学的定量方法，这是一个研讨会计划，它带来了领先的学术监管 以及工业科学家，学生研究演讲和年度务虚会。计划的目标是招募8- 12杰出博士每年的学生，再加上至少一名学生参加pharm.d./ph.d的合并。程度。 代表性不足的少数民族学生通过许多教师活动积极招募，并代表 我们20％的学生。毕业后，新的PSPG博士科学家将拥有道德，知识和工具 成为独立研究人员的必要 在整个职业生涯中，对药物科学和药物基因组学领域的贡献。