Pharmaceutical Sciences and Pharmacogenomics

药物科学和药物基因组学

• 批准号: 10269779
• 负责人: Nadav Ahituv
• 金额: $ 47.61万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-07-01 至 2027-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10269779
• 关键词: Pharmacogenomics; Pharmacologic Substance; Science

PROJECT SUMMARY The Pharmaceutical Sciences and Pharmacogenomics (PSPG) Graduate Program is a unique, dynamic, contemporary program in pharmaceutical sciences and pharmacogenomics at the University of California San Francisco that attracts diverse faculty and students who share a common interest in applying basic sciences to challenging research topics in drug development and precision drug therapy. The graduate program reflects exciting scientific developments in the area of genomics, quantitative and systems pharmacology, therapeutics and computation that have far-reaching implications to the pharmaceutical and pharmacological sciences. The goal of the PSPG graduate program is to educate and train Ph.D. students to conceptualize, design and execute innovative scientific research in the interdisciplinary scientific areas encompassed by modern pharmaceutical sciences. The program brings together 66 well-funded faculty members spanning 17 departments. This multidisciplinary and unique graduate program has a dual focus: 1) pharmaceutical sciences and drug development, including molecular and systems pharmacology, drug delivery and therapeutic bioengineering, gene therapy and pharmacokinetics/pharmacodynamics and modeling; and 2) pharmacogenomics, the application of genetics and genomics for the development of novel therapeutics and the optimal use of drugs in individual patients for precision medicine. The training program includes a series of core courses providing an in-depth understanding of the principles of pharmaceutical sciences and pharmacogenomics, including an innovative new core course in systems pharmacology. Core courses are complemented by electives covering advanced drug delivery and pharmacokinetic principles, principles of genetics and cell biology, bioinformatics, tissue and organ biology, CRISPR therapeutics and computer programming. Students also participate in laboratory rotations that expose them to the diversity of potential projects available for their dissertation research and a university-wide course on responsible conduct of research. The program immerses trainees in the culture of science through a journal club with students across four basic science graduate programs that are focused on quantitative approaches to studying biology, a seminar program which brings in leading academic, regulatory and industrial scientists, student research presentations, and an annual retreat. The program goal is to recruit 8- 12 outstanding Ph.D. students per year, plus at least one student for a combined Pharm.D./Ph.D. degree. Underrepresented minority students are actively recruited through a number of faculty activities and represent 20% of our students. Upon graduation, the new PSPG Ph.D. scientist will have the ethics, knowledge and tools necessary to become independent researchers, and also the passion and enthusiasm to make impactful contributions to the pharmaceutical sciences and pharmacogenomics field throughout their career.

项目概要 药物科学和药物基因组学 (PSPG) 研究生项目是一个独特的、充满活力的、 加州大学圣保罗分校当代药物科学和药物基因组学项目 弗朗西斯科吸引了不同的教师和学生，他们对应用基础科学有共同的兴趣 药物开发和精准药物治疗方面具有挑战性的研究课题。研究生课程反映了 基因组学、定量和系统药理学、治疗学领域令人兴奋的科学发展 和计算对制药和药理学具有深远的影响。这 PSPG 研究生项目的目标是教育和培养博士。学生构思、设计和执行 现代制药所涵盖的跨学科科学领域的创新科学研究 科学。该项目汇集了 17 个系的 66 名资金充足的教员。这 多学科且独特的研究生课程具有双重重点：1）制药科学和药物 开发，包括分子和系统药理学、药物输送和治疗生物工程， 基因治疗和药代动力学/药效学和建模； 2）药物基因组学， 遗传学和基因组学在新疗法开发和药物最佳使用中的应用 个体患者的精准医疗。培训计划包括一系列核心课程，提供 深入了解药物科学和药物基因组学的原理，包括 系统药理学创新的新核心课程。核心课程辅以选修课，涵盖 先进的药物输送和药代动力学原理、遗传学和细胞生物学原理、生物信息学、 组织和器官生物学、CRISPR 疗法和计算机编程。学生也参与 实验室轮换让他们接触到可用于其论文研究的潜在项目的多样性 以及关于负责任的研究行为的全校课程。该计划让学员沉浸在文化中 通过期刊俱乐部与学生一起研究科学，该俱乐部专注于四个基础科学研究生课程 关于研究生物学的定量方法，这是一个研讨会项目，引入了领先的学术、监管 和工业科学家、学生研究报告和年度静修会。该计划的目标是招募 8- 12名优秀博士每年学生，加上至少一名联合药学博士/博士学生。程度。 通过一些教师活动积极招募少数族裔学生并代表 我们学生的20%。毕业后，新的 PSPG 博士。科学家将拥有道德、知识和工具 成为独立研究人员所必需的，以及做出有影响力的热情和热情 在他们的整个职业生涯中对药物科学和药物基因组学领域做出了贡献。