Transcriptional and translational regulation of the neuronal protein tau

神经元蛋白 tau 的转录和翻译调控

• 批准号: DP240101654
• 负责人: Prof Lars Ittner
• 金额: $ 50.91万
• 依托单位: Macquarie University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2024
• 资助国家: 澳大利亚
• 起止时间: 2024-01-01 至 2026-12-31
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP240101654
• 关键词: Transcriptional; translational; regulation; neuronal; protein

The microtubule-associated protein tau is important for brain development and performance. To perform these functions, tau levels and its variants are tightly controlled in brain cells. However, the factors that regulate tau remain largely unknown. This project will employ latest gene technologies to identify the molecular regulators of tau, for each step of the process from DNA to the protein. The outcome of this study will significantly advance our understanding of gene regulation and mechanisms for controlling protein levels and contribute to a deeper understanding of brain function during development and aging.

微管相关的蛋白质TAU对于脑发育和性能很重要。为了执行这些功能，tau水平及其变体在脑细胞中受到严格控制。但是，调节tau的因素仍然在很大程度上未知。该项目将采用最新的基因技术来识别Tau的分子调节剂，以从DNA到蛋白质的过程的每个步骤。这项研究的结果将大大提高我们对控制蛋白质水平的基因调节和机制的理解，并有助于更深入地了解发育和衰老期间的大脑功能。