The tau interactome

tau 相互作用组

• 批准号: DP170100781
• 负责人: Prof Lars Ittner
• 金额: $ 36.27万
• 依托单位: Macquarie University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP170100781
• 关键词: tau; interactome

This project aims to decipher tau-dependent mechanisms at the molecular level to understand its pivotal role in neuronal integrity and function. Tau is a predominantly axonal protein with microtubule stabilising properties and has been implicated in several neurodegenerative disorders, including Alzheimer’s disease. Knowledge of its other physiological roles in the brain is limited, although it seems to be involved in signalling processes. The expected outcome of this study is a deeper understanding of brain function during development and aging, which may ultimately contribute to new preventive treatments and medical care strategies.

该项目旨在破译tau依赖性机制，以了解其在神经元完整性和功能中的关键作用。 Tau是一种主要具有微管稳定特性的轴突蛋白，已在包括阿尔茨海默氏病在内的几种神经退行性疾病中实施。尽管它似乎参与了信号传导过程，但了解其在大脑中其他身体角色的知识是有限的。这项研究的预期结果是对开发和衰老期间大脑功能的更深入了解，这最终可能有助于新的预防治疗和医疗策略。