Training Program in Genomic Medicine

基因组医学培训计划

• 批准号: 10415080
• 负责人: Lynn Jorde
• 金额: $ 32.48万
• 依托单位: UNIVERSITY OF UTAH
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-06-01 至 2026-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10415080
• 关键词: Genomic medicine; Training Programs

ABSTRACT The T32 Genomic Medicine Training Program at the University of Utah prepares pre- and postdoctoral trainees to be well-rounded, collaborative leaders in genomic medicine. Building on a strong institutional record of training in genomics and the unique training environment of the multidisciplinary Center for Genomic Medicine at University of Utah Health, the two-year basic research track training program consists of coursework, a mentored research experience, experiential learning activities, extensive interactions with a broad community of genomic medicine researchers, and career development activities. Core courses cover the ethical, legal and social implications of genomic medicine, grant writing techniques, and practical skills for applying computational tools for disease-gene discovery and patient genome interpretation. A mentored genomic medicine research experience in a team science environment is the heart of the training program. Each trainee will have a multidisciplinary mentoring committee, drawn from a mentor pool of 34 MD and PhD genomic medicine researchers. This highly collaborative mentor community possesses expertise in the many disciplines that underpin genomic medicine, including human genetics, bioinformatics, epidemiology, statistics, molecular diagnostics, and pharmacogenomics. Trainees will benefit from several unique resources and collaborators in the Center for Genomic Medicine: the Utah Genome Project, an independently funded research project in which thousands of members of large Utah disease pedigrees are undergoing whole-genome sequencing; the Utah Center for Genetic Discovery, the University’s computational genomics engine and hub for development of software tools and algorithms for genome interpretation; ARUP Laboratories, the University’s national reference lab and a leader in developing genomics-based clinical diagnostic tests; the Penelope Program, the University’s clinic for rare and undiagnosed disease, which is part of the Undiagnosed Disease Network; the Utah NeoSeq Project, an initiative to bring rapid whole genome sequencing to the neonatal intensive care unit; and the Huntsman Cancer Institute, a National Cancer Institute Designated Comprehensive Cancer Center and home to extensive cancer genomics and precision oncology projects. Each of these will provide immersion opportunities in genomic medicine. The overall goals of the T32 program are: to teach trainees to apply cutting-edge bioinformatics and computational tools to analyze genomic datasets; to work productively with interdisciplinary teams in the clinical application of genomic data; to protect and communicate effectively with research participants; and to advance an independent research career in genomic medicine. At steady state, the training program will include five predoctoral and four postdoctoral trainees each year. In the past funding period, nine postdoctoral trainees were appointed, advancing their careers in genomic medicine. Trainee outcomes data are tracked, and best practices and course materials will be disseminated across the NHGRI training network.

抽象的 犹他大学 T32 基因组医学培训计划为博士前和博士后培训生做好准备 以强大的机构培训记录为基础，成为基因组医学领域全面、协作的领导者。 基因组学和多学科基因组医学中心独特的培训环境 犹他大学健康分校，为期两年的基础研究轨道培训计划包括课程作业、指导 研究经验、体验式学习活动、与广泛的基因组学社区的广泛互动 医学研究人员和职业发展活动核心课程涵盖伦理、法律和社会。 基因组医学的影响、资助写作技巧以及应用计算工具的实用技能 用于疾病基因发现和患者基因组解释的指导基因组医学研究。 团队科学环境中的体验是培训计划的核心。 多学科指导委员会，由 34 名基因组医学博士和博士组成的导师库组成 这个高度协作的导师社区拥有许多学科的专业知识。 支撑基因组医学，包括人类遗传学、生物信息学、流行病学、统计学、分子生物学 学员将受益于一些独特的资源和合作者。 基因组医学中心：犹他州基因组计划，一个独立资助的研究项目，其中 犹他州大型疾病谱系的数千名成员正在接受全基因组测序； 遗传发现中心，大学的计算基因组学引擎和开发中心 用于基因组解释的软件工具和算法；ARUP 实验室，该大学的国家参考机构 实验室和开发基于基因组学的临床诊断测试的领导者； 罕见和未确诊疾病诊所，属于犹他州 NeoSeq 的一部分； 项目，一项将快速全基因组测序引入新生儿重症监护病房的举措； 亨斯曼癌症研究所是国家癌症研究所指定的综合癌症中心，也是 广泛的癌症基因组学和精准肿瘤学项目中的每一个都将提供沉浸机会。 T32 项目的总体目标是：教授学员应用尖端技术。 用于分析基因组数据集的生物信息学和计算工具；有效地与跨学科合作 基因组数据临床应用团队；保护研究并有效沟通； 参与者；并在稳定状态下推进基因组医学的独立研究事业。 该项目每年将包括 5 名博士前培训生和 4 名博士后培训生，在过去的资助期内，有 9 名。 任命了博士后学员，推进了他们在基因组医学领域的职业生涯。 跟踪，最佳实践和课程材料将在 NHGRI 培训网络中传播。