Training Program in Genomic Medicine

基因组医学培训计划

• 批准号: 9278223
• 负责人: Lynn Jorde
• 金额: $ 30.18万
• 依托单位: UNIVERSITY OF UTAH
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-06-01 至 2021-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9278223
• 关键词: Genomic medicine; Training Programs

 DESCRIPTION (provided by applicant): The University of Utah Health Sciences (UUHS) T32 Training Program in Genomic Medicine will prepare physicians and basic scientists to be leaders in genomic medicine. Building on a strong institutional record of training in genomics, the two-year basic research track training program consists of coursework, a mentored research experience, extensive interactions with a broad community of genomic medicine researchers, and career development activities. The coursework includes foundational training in genetics, statistics, epidemiology, data management, and clinical trial design. Two newly designed courses focus on key aspects of genomic medicine. One explores the ethical, legal and social implications (ELSI) of genomic medicine, including the challenges of communicating genomic information to research participants. The other teaches practical skills for applying computational tools for disease-gene discovery, patient genome interpretation, and big data management in research and clinical settings. A mentored research experience in a team science environment is the heart of the training program. Each trainee will have a multidisciplinary mentoring committee, drawn from a mentor pool of 33 MD and PhD genomic medicine researchers. This highly collaborative mentor community possesses expertise in the many disciplines that underpin genomic medicine, including human genetics, bioinformatics, epidemiology, statistics, molecular diagnostics, and pharmacogenomics. The research experiences will include structured exposure to practical applications of genomic medicine in both clinical and diagnostic laboratory settings. Trainees will benefit from several unique resources: the Utah Genome Project, an independently funded research project in which thousands of members of large Utah disease pedigrees are undergoing whole-genome sequencing; ARUP Laboratories, the University's national reference lab and a leader in developing genomics-based clinical diagnostic tests; and four UUHS hospitals committed to integrating genomic medicine to improve health care. Each of these will provide immersion opportunities in genomic medicine. The overall goals of the T32 program are: to teach trainees to apply cutting-edge bioinformatics and computational tools to analyze genomic datasets; to use genomic medicine data standards to facilitate integration of genomic data into electronic health records; to work productively with interdisciplinary teams in the clinical application of genomic data; to communicate effectively with human participants in genomic medicine research; and to advance an independent research career in genomic medicine. The training program will have three training slots in year 1 and six slots in years 2-5, to train a total of 15 MDs and PhDs. Trainee outcomes data will be tracked, and best practices and course materials will be disseminated across the NHGRI training network to help to produce basic and clinical scientists who can seamlessly integrate all aspects of genomic medicine in their research and clinical practice.

 描述（由申请人提供）：犹他大学健康科学大学 (UUHS) T32 基因组医学培训计划将帮助医生和基础科学家成为基因组学领域的领导者，该项目建立在基因组学培训机构的良好记录基础上，为期两年的基础培训。研究轨道培训计划包括课程作业、指导研究经验、与广泛的基因组医学研究人员的广泛互动以及职业发展活动。课程作业包括遗传学、统计学、流行病学、数据管理和临床试验方面的基础培训。两门新设计的课程侧重于基因组医学的关键方面，其中一门探讨基因组医学的伦理、法律和社会影响（ELSI），包括向研究参与者传达基因组信息的挑战。培训计划的核心是在研究和临床环境中进行疾病基因发现、患者基因组解释以及大数据管理。由 33 名医学博士和博士基因组医学研究人员组成。高度协作的导师社区拥有支持基因组医学的许多学科的专业知识，包括人类遗传学、生物信息学、流行病学、统计学、分子诊断和药物基因组学。研究经验将包括结构化地接触基因组医学在临床和诊断实验室的实际应用。学员将受益于一些独特的资源：犹他州基因组项目，这是一个独立资助的研究项目，其中数千名犹他州大型疾病谱系的成员正在进行全基因组测序；大学的国家参考实验室和开发基于基因组学的临床诊断测试的领导者；以及致力于整合基因组医学以改善医疗保健的四家 UUHS 医院。 T32 计划的总体目标是：教导学员应用尖端的生物信息学和计算工具来分析基因组数据集；使用基因组医学数据标准来促进基因组数据整合到电子健康记录中；与跨学科团队在基因组数据的临床应用中进行富有成效的合作；有效地与人类参与者一起参与基因组医学研究；并推进基因组医学的独立研究事业。该培训计划将在第一年提供 3 个培训名额，在第 2-5 年提供 6 个培训名额，总共培训 15 名人员。 医学博士和博士生的成果数据将被跟踪，最佳实践和课程材料将在 NHGRI 培训网络中传播，以帮助培养能够将基因组医学的各个方面无缝整合到研究和临床实践中的基础和临床科学家。