Histology and Imaging Core

组织学和成像核心

• 批准号: 10414548
• 负责人: DEREK C MOLLIVER
• 金额: $ 26.03万
• 依托单位: UNIVERSITY OF NEW ENGLAND
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-06-01 至 2027-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10414548
• 关键词: Academia; Advisory Committees; Antibodies; Applications Grants; Award; Biological; Biomedical Research; Brain; Businesses; Caliber; Caring; Centers of Research Excellence; Collaborations; Communication; Communities; Computer software; Contract Services; Contracts; Data; Densitometry; Development; Ensure; Equipment; Evaluation; Extramural Activities; Faculty; Fee-for-Service Plans; Feedback; Fees; Fluorescence; Freezing; Funding; Goals; Grant; Histologic; Histology; Human Resources; Image; Image Analysis; Immunohistochemistry; Income; Industry; Institutes; Institution; Investments; Laboratories; Laboratory Personnel; Maine; Maintenance; Medical center; Methods; Microscope; Microtome - medical device; New England; Pain; Paraffin Embedding; Performance; Phase; Plastic Embedding; Procedures; Provider; Publications; Reproducibility; Research; Research Institute; Research Methodology; Research Personnel; Research Project Grants; Research Support; Resources; Role; Sampling; Scanning; Secure; Sensory; Service delivery model; Services; Slide; Stains; Strategic Planning; Stream; Students; System; Technical Expertise; Time; Tissue Embedding; Training; United States National Institutes of Health; Universities; Validation; Wages; Work; base; bone; cryostat; experience; experimental study; imaging capabilities; industry partner; instrumentation; outreach; programs; quantitative imaging; research facility; success; synergism; two photon microscopy; two-photon; voucher

Prior to the initiation of this COBRE, there were no research cores at the University of New England (UNE). Phase 1 and 2 COBRE support resulted in the development of the Histology and Imaging Core (HIC) into a critical resource for COBRE investigators and the broader research community at UNE and the region. The Core's histology instrumentation includes tissue embedding equipment, microtomes, vibratomes, cryostats and slide staining workstations. Imaging equipment includes brightfield, widefield fluorescence, slide-scanning, confocal and 2-photon microscopes. Technical services include tissue embedding, sectioning, conventional histology stains, immunohistochemistry, and antibody optimization and validation. In Phase 2, the HIC provided services to 38 investigators (15 UNE-COBRE, 8 UNE-non- COBRE, 10 in external academia and 5 in industry), and trained 175 laboratory personnel. Also in Phase 2, a fee-for- service model was initiated, and strong partnerships with other IDeA institutions at Brown University and Maine Medical Center Research Institute were developed that, in combination with internal users, have the potential to be long-term sustaining providers of Core income. Special care has been taken to ensure that the Core capabilities do not duplicate those offered by other COBRE- and INBRE-supported research cores. Instead, the Core has strategically specialized in unique services such the processing of brain samples, bone samples and marine-derived samples. In Phase 3, the HIC will maintain its current outstanding level of performance, critically assess its performance, continue to develop its personnel professionally, and hire an additional technician to keep pace with the needs of its broadening user base. The HIC will also undertake a rigorous strategic planning program under the direction of a UNE expert in small business strategy, with the goal of completing its transition to post-award sustainability. The HIC has secured critical additional institutional support, including guarantees of post-Phase 3 salary for key Core personnel, protected time for Directors, laboratory space, assistance with maintenance and service contracts, and an internally funded core voucher program and continuation of the UNE mini-grant program for those striving for extramural support. Through these efforts, the UNE HIC will continue to provide excellent critical research support to its many users, ensuring maximum utility to UNE and the broader research community in Phase 3 and beyond.

在启动此毛绒之前，新英格兰大学（UNE）没有研究核心。阶段1和 2毛线支持导致组织学和成像核心（HIC）发展为关键资源 联合国UNE和该地区的COBRE研究人员和更广泛的研究社区。核心的组织学仪器 包括组织嵌入设备，微失位，振动剂，低温器和幻灯片染色工作站。成像 设备包括Brightfield，广阔的荧光，幻灯片扫描，共焦和2光子显微镜。技术的 服务包括组织嵌入，切片，常规组织学染色，免疫组织化学和抗体 优化和验证。在第2阶段，HIC为38位调查人员提供了服务（15个UNE-COBRE，8 une-non-- 柯布雷，外部学术界10个，行业中有5个），并培训了175名实验室人员。同样在第2阶段，收费 服务模型已启动，并与布朗大学和缅因州医学的其他想法机构建立了牢固的合作伙伴关系 开发了中心研究所，与内部用户相结合，有可能长期 维持核心收入的提供者。已经特别注意确保核心功能不复制 那些由其他杂es和近亲支持的研究核心提供的核心。相反，核心在战略上专门从事 独特的服务，例如脑样本，骨骼样本和海洋衍生样品的处理。在第3阶段，HIC将 保持其当前出色的绩效水平，严格评估其绩效，继续发展其人员 专业，并聘请一名额外的技术人员来跟上其扩大用户群的需求。 HIC会 还在UNE小型企业策略专家的指导下进行严格的战略规划计划，并 完成其过渡到后可持续性的目标。 HIC确保了关键的额外机构 支持，包括保证关键核心人员的阶段3工资，为董事，实验室保护时间 空间，维护和服务合同的协助以及内部资助的核心凭证计划和延续 努力寻求壁外支持的人的UNE迷你节目计划。通过这些努力，UNE HIC将会 继续向许多用户提供出色的关键研究支持，确保最大的效用UNE和 在第3阶段及以后的更广泛的研究社区。