CWRU Center for Excellence on the Impact of Substance Use on HIV

CWRU 物质使用对艾滋病毒影响卓越中心

基本信息

批准号：
10632089
负责人：
Alan David Levine
金额：
$ 321.57万
依托单位：
CASE WESTERN RESERVE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-09-15 至 2026-05-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10632089
关键词：
Acceleration Acquired Immunodeficiency Syndrome Affect Award Basic Science Behavioral Behavioral Research Bioinformatics Biometry Biomimetics Brain Cannabis Capital Caring Cell model Cells Cities Clinic Clinical Clinical Investigator Clinical Research Cocaine misuse Communities Community Outreach Complex Computational Biology County Databases Development Diagnosis Discipline Disease Drug usage Education Equipment Exposure to Faculty Foundations Functional disorder Funding Grant HIV HIV/HCV Health Hepatitis C co-infection Hospitals Immune Immunologics Immunosuppression Individual Infrastructure International Investigation Leadership Link Medical center Medicine Memory impairment Mental Health Mentors Methamphetamine Methods Modeling Molecular Motivation Mucous Membrane Myelogenous National Institute of Drug Abuse Neurocognitive Deficit Neurologic Neurological outcome Opioid Outcome Pathogenesis Patient Recruitments Patients Persons Physician Executives Positioning Attribute Prevention Research Prevention education Process Proteomics Public Health Reporting Research Research Personnel Research Support Resources Risk Rural Schools Services Social Sciences Strategic Planning Substance Use Disorder Surveys Systems Biology Teacher Professional Development Technology Tissues Translational Research Trauma Underserved Population United States Department of Veterans Affairs Universities University Hospitals Victimization Violence behavioral health intervention behavioral outcome biobank career clinical database cocaine use cohort collaborative environment comorbidity design experience gastrointestinal immune reconstitution induced pluripotent stem cell induced pluripotent stem cell technology innovation insight interdisciplinary collaboration lecturer lipidomics marijuana use medical schools metabolomics methamphetamine use microbiome neuroAIDS neuroinflammation new technology next generation opioid use programs service intervention sexual risk behavior stem cells substance misuse substance use suburb symposium synergism three-dimensional modeling transcriptomics violence prevention

项目摘要

Project Summary - Overview The newly developed CWRU (Case Western Reserve University) Center for Excellence on the Impact of Substance Use on HIV was conceived in August 2017 and was initiated to effectively promote excellence in basic, translational, and clinical research concerning the intersection between substance use and HIV. The Center for Excellence includes 12 NIDA-funded Investigators who collectively hold 9 R01, 2 DP1, 3 R34, 2 R44, 1 U01, and 2 K01 drawn from the CWRU School of Medicine, University Hospitals Cleveland Medical Center, MetroHealth Medical Center, the Cleveland Clinic Foundation, the Louis Stokes Cleveland Veterans Administration Medical Center, the CWRU Mandel School of Applied Social Sciences, the Begun Center for Violence Prevention Research and Education, and the Cuyahoga County, Lorain County, and City of Cleveland Departments of Health. Major research strengths in the Center for Excellence include impact of drug use on HIV immunopathogenesis, HIV latency and Cure, NeuroAIDS, gastrointestinal dysfunction, sexual risk behavior, and HIV and HCV co-infections. Our studies are anchored by advanced computational, systems biology, biomimetic models, and induced pluripotent stem cell (iPSC) technologies that provide the opportunity to perform meta-omics analyses of the impact of opioid, methamphetamine, cannabis, and cocaine misuse on several clinical, virological, immunological, behavioral, and neurological outcomes of HIV disease. The Center for Excellence has the following Specific Aims: • Provide scientific leadership to position the Center at the forefront of substance use disorder research and function as a national research resource for the study of drug use in persons with HIV. • Establish an administrative infrastructure that maintains fiscal and management oversight of the Cores. • Apply advanced Computational Biology, Primary Cells, Biomimetic models, and iPSC- derived Cells to study of the impact of substance use on HIV disease. • Support translational, clinical, and behavioral research through access to unique clinical cohorts of persons with substance use disorder with HIV and at risk for HIV. • Accelerate junior faculty development and encourage experienced faculty to enter the substance use research arena to support the next generation of investigators. • Participate in community outreach.

项目摘要 - 概述新开发的CWRU（Case Western Reserve University） 2017年8月构思了物质使用对艾滋病毒的影响，并有效地发起了促进有关基础，翻译和临床研究的卓越，涉及物质使用和艾滋病毒。卓越中心包括12位NIDA资助的调查人员从CWRU学校中绘制的9 R01、2 DP1、3 R34、2 R34、2 R44、1 U01和2 K01 医学，大学医院克利夫兰医疗中心，克利夫兰甲都有卫生医疗中心临床基金会，路易斯·斯托克斯克利夫兰退伍军人管理局医疗中心，CWRU 曼德尔应用社会科学学院，开端的暴力预防研究中心，教育，洛兰县的库亚霍加县和克利夫兰市卫生部门。卓越中心的主要研究优势包括吸毒对艾滋病毒的影响免疫致病，艾滋病毒潜伏和治愈，神经辅助，胃肠道功能障碍，性风险行为以及艾滋病毒和HCV共同感染。我们的研究是由高级计算的基础系统生物学，仿生模型和诱导多能干细胞（IPSC）技术提供了对OID，甲基苯丙胺的影响进行荟萃分析的机会大麻和可卡因在几种临床，病毒学，免疫学，行为和艾滋病毒疾病的神经学结果。卓越中心具有以下具体目标： •提供科学领导才能将中心放在物质使用的最前沿障碍研究和功能是用于吸毒研究的国家研究资源在艾滋病毒的人身上。 •建立一个管理财政和管理监督的行政基础设施核心。 •应用先进的计算生物学，原代细胞，仿生模型和IPSC- 衍生细胞研究物质使用对HIV疾病的影响。 •通过获得独特的临床，支持翻译，临床和行为研究患有艾滋病毒和艾滋病毒风险的药物使用障碍的人群。 •加速初级教师的发展，并鼓励有经验的教师进入药物使用研究领域来支持下一代研究人员。 •参加社区外展。