Administrative Core A

行政核心A

• 批准号: 10304583
• 负责人: Alan David Levine
• 金额: $ 69.74万
• 依托单位: CASE WESTERN RESERVE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-15 至 2026-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10304583
• 关键词: Administrative Personnel; Advertising; Advisory Committees; Anti-Inflammatory Agents; Astrocytes; Attenuated; Automobile Driving; Award; Behavioral; Big Data; Biomimetics; Blood - brain barrier anatomy; Cannabis; Capital; Cardiovascular system; Cell model; Cells; Chronic; Cities; Clinical; Cocaine; Collaborations; Communication; Communities; Community Outreach; Computational Biology; Computer software; Corpus striatum structure; County; Data Collection; Databases; Diagnosis; Disease; Dopamine; Dose; Dose-Limiting; Drug usage; Equipment; Evaluation; Excision; Exercise; Exposure to; Faculty; Faculty Recruitment; Functional disorder; Funding; Gap Junctions; Genetic; Gliosis; Growth; HIV; Health; Immunosuppression; Individual; Inflammation; Institution; International; Investments; Leadership; Mediating; Medicine; Memory impairment; Mental Health; Mentors; Mentorship; Methamphetamine; Microglia; Modification; Motivation; National Institute of Drug Abuse; Neurocognitive Deficit; Opioid; Oxidative Stress; Participant; Pathology; Persons; Policies; Positioning Attribute; Predisposition; Process; Proteomics; Public Health; Publishing; Recommendation; Reproducibility; Research; Research Activity; Research Personnel; Research Project Grants; Research Support; Resources; Science; Scientist; Services; Strategic Planning; Suggestion; Surveys; System; Systems Biology; Training; Training Programs; United States National Institutes of Health; Ursidae Family; Virus; Virus Latency; Virus Replication; base; biobank; comorbidity; equipment acquisition; glial activation; gray matter; immune reconstitution; improved; induced pluripotent stem cell; innovation; lipidomics; medical schools; member; metabolomics; microbiome; neuroAIDS; neuroinflammation; novel; organizational structure; outreach; outreach program; programs; recruit; responsible research conduct; single cell analysis; substance use; technological innovation; transcriptomics; viral rebound; web site

Project Summary Core A – Administrative Core The CWRU Center for Excellence on the Impact of Substance Use on HIV Administrative Core is responsible for driving the direction of Substance Use in HIV research at our institutions by being responsive to the evolving research needs of Center investigators. The Administrative Core provides the leadership and organizational structure to coordinate, support, and enhance the efforts of the Center members and bears responsibility for the scientific, administrative, budgetary, and operational aspects of the Center. The major strengths of the Center include scientific and technological innovation and expertise to pursue our four main objectives in studying the impact of Substance Use on HIV: (i) Methamphetamine & HIV and immunosuppression on neurocognitive impairment, due to glial activation, oxidative stress, astrocyte gliosis, neuroinflammation, and HIV reactivation. (ii) Cocaine & HIV dysregulation of the fronto-striatal dopamine circuit in microglia, driving the progression of motivational dysfunction and increasing susceptibility to HIV and favoring HIV replication and latency. (iii) Opioid & HIV modulation of viral replication, virus-mediated pathology, blood-brain- barrier, immunosuppression, viral latency, and viral rebound. (iv) Hormetic effect of Cannabis & HIV, as anti-inflammatory at low doses, limiting HIV viral replication and attenuating HIV-related immunosuppression and inflammation, and at high or chronic doses, associating with reduced gray matter volume and memory deficits. The Administrative Core A has developed a forward-looking Strategic Planning process that includes input from Center members and leadership, as well as institutional administrative personnel. Implementation of the Strategic Plan includes (a) organizing, managing, and advertising the Research Support Cores, (b) obtaining and effectively using institutional funds to further invest in junior and underrepresented investigators in medicine with novel research programs in a team science setting, (c) exercise fiscal constraint and advance external funding, (d) develop educational, policy, and outreach activities that fully engage Center investigators and local departments of publish health, and (e) fairly apply well-publicized, agreed upon evaluations. The Specific Aims for the Center Administrative Core A are: • To coordinate and implement a rigorous annual review and strategic planning process. • To leverage institutional support to enhance Substance Use research at our institutions. • To support our significant footprint in systems biology and ‘big data’ collection, management, storage, and analysis. • To stimulate training, educational, and community outreach activities throughout the Center for Excellence. • To improve communications throughout the Center and oversee responsible, rigorous, and reproducible research activities. • To serve as national research resource in the drug use in HIV research field.

项目摘要核心A - 行政核心 CWRU卓越中心对物质使用对艾滋病毒行政的影响 核心负责推动我们机构的艾滋病毒研究中的物质使用方向 通过响应中心研究人员不断发展的研究需求。行政 核心提供了协调，支持和增强的领导和组织结构 中心成员的努力，负责科学，行政， 预算和中心的运营方面。中心的主要优势包括 科学和技术创新和专业知识，以追求我们的四个主要目标 研究药物使用对艾滋病毒的影响： （i）甲基苯丙胺和艾滋病毒以及神经认知障碍的免疫抑制， 由于神经胶质激活，氧化应激，星形胶质细胞神经病，神经炎症和HIV 重新激活。 （ii）可卡因和HIV失调的额叶多巴胺回路小胶质细胞， 推动动机功能障碍的进展和对 艾滋病毒并喜欢艾滋病毒复制和潜伏期。 （iii）病毒复制，病毒介导的病理学，血脑验的阿片类药物和HIV调节 屏障，免疫抑制，病毒潜伏期和病毒反弹。 （iv）大麻和艾滋病毒的刺激性作用，作为低剂量的抗炎作用，限制HIV 病毒复制和衰减HIV相关的免疫抑制和炎症， 并以高剂量或慢性剂量，与灰质体积减少相关 内存定义。 行政核心A制定了一个前瞻性的战略规划过程 包括中心成员和领导力的意见以及机构行政 人员。战略计划的实施包括（a）组织，管理和 广告研究支持核心，（b）获得并有效地使用机构资金 通过新的研究进一步投资于医学的初级和代表性不足的研究者 团队科学环境中的计划，（c）行使财政限制并提高外部资金， （d）开发教育，政策和外展活动，使中心调查人员完全参与 以及当地出版健康部门，（e）公布良好的商定，同意 评估。中心行政核心A的具体目标是： •协调和实施严格的年度审查和战略规划过程。 •利用机构支持来增强我们机构的药物使用研究。 •为了支持我们在系统生物学和“大数据”收集方面的重要足迹， 管理，存储和分析。 •刺激整个过程中的培训，教育和社区外展活动 卓越中心。 •改善整个中心的沟通，并监督负责任的，严格的， 和可再现的研究活动。 •作为HIV研究领域药物使用的国家研究资源。