SCH: INT: Collaborative Research: Context-Adaptive Multimodal Informatics for Psychiatric Discharge Planning

SCH：INT：合作研究：用于精神病出院计划的上下文自适应多模态信息学

基本信息

批准号：
10392429
负责人：
JUSTIN T BAKER
金额：
$ 28.42万
依托单位：
MCLEAN HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-04-15 至 2025-02-28
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10392429
关键词：
Address Back Behavior Behavioral Biological Markers Caring Chronic Disease Clinical Clinical Research Complex Computer software Data Data Set Dependence Development Diagnostic Discharge Plannings Disease Ensure Equipment Goals Healthcare Healthcare Systems Hospitalization Hospitals Human Individual Informatics Inpatients Intelligence Interview Judgment Knowledge Linear Models Measurement Measures Medical Mental Health Mental Health Services Mental disorders Methods Mission Modality Modeling Monitor Names National Institute of Mental Health Outcome Patients Population Process Protocols documentation Proxy Psychiatry Psychotic Disorders Readiness Research Resources Self Perception Shapes Social Environment Symptoms System Technology Telemedicine Testing Time Universities Validation Work acceptability and feasibility behavior measurement behavioral health biomarker development care delivery clinical care clinical decision-making clinical encounter clinical practice computer framework cost fundamental research health assessment improved insight longitudinal dataset multimodality neural model novel novel strategies predict clinical outcome predictive marker prognostic provider behavior psychiatric symptom remote sensing scaffold severe mental illness social trustworthiness

项目摘要

Which psychiatric symptoms and behaviors are the most important to assess and manage during critical points in psychiatric healthcare, such as the time leading up to hospital discharge? At present, psychiatry lacks objective tests that could inform this and other clinically challenging–and potentially costly– decisions. Establishing valid objective markers of psychiatric disease processes is especially challenging compared with the development of biomarkers in other 5elds. One key challenge is lack of available data from psychiatrically ill patients during key periods in their care trajectory, which the present project seeks to address. A second major challenge, also addressed as a core feature in this project, is the complex, context-dependence of human behavioral expression, which greatly complicates efforts to establish robust, objective measures that re6ect underlying mental health disease processes. This project will address both barriers, introducing a new computational framework, named Context-Adaptive Multimodal Informatics, to identify and evaluate behavioral biomarkers related to discharge-readiness and symptoms in severe mental illness. The project aims to address 5ve fundamental research challenges: (1) Acquire a multimodal psychiatric discharge-planning dataset of 400 inpatients with severe mental illness; (2) Create self-aware linear and neural models to identify multimodal behavioral biomarkers; (3) Develop context-sensitive linear and neural models to contextualize behavioral biomarkers and quantify the in6uence of context on behavior; (4) Build a new adaptive assessment planning framework which creates a personalized patient analysis to rank contexts and modalities for the next assessment session; (5) Assess the trustworthiness and generalizability of our measurements, models, and insights. This research will improve basic understanding of social context and behavioral biomarkers, build objective measures for mental health assessment, and more broadly, pave the way for a restructured care-delivery system in which resources are allocated intelligently to ensure assessments are informative with respect to desired clinical objectives.

在关键时期，哪些精神病症状和行为是评估和管理最重要的精神病医疗保健的观点，例如进入医院出院的时间？目前，精神病学缺乏客观的测试，这些测试可能会为这一和其他临床挑战以及可能成本高昂的挑战提供依据 - 决定。建立有效的精神疾病过程的客观标记尤其具有挑战性与其他5种生物标志物的发展相比。一个主要挑战是缺乏可用数据从精神病患者的关键时期中的护理轨迹中，本项目寻求该轨迹解决。第二个主要挑战，也作为该项目的核心功能，是复杂的，人类行为表达的上下文依赖性，这极大地复杂化建立了强大的客观措施可以重新进行基本的心理健康疾病过程。这个项目将解决两个障碍，引入了一个新的计算框架，名为上下文自适应多模式信息学，识别和评估与排放准备和有关的行为生物标志物和严重精神疾病的症状。该项目旨在应对5ve基本研究挑战：（1）获取400名住院患者的多模式精神释放计划数据集疾病; （2）创建自我意识的线性和神经模型以识别多模式行为生物标志物；（3）开发上下文敏感的线性和神经模型，以将行为生物标志物进行背景化并量化关于行为的上下文的6个；（4）建立一个新的自适应评估计划框架创建个性化的患者分析，以对下一次评估会议进行对上下文和方式进行排名；（5）评估我们的测量，模型和见解的可信度和普遍性。这项研究将改善对社会环境和行为生物标志物的基本理解，建立精神健康评估的客观测量，更广泛地为恢复的方式铺平了道路智能分配资源以确保评估的护理递送系统关于所需的临床目标的信息。