2022 Marine Natural Products Gordon Research Conference and Seminar

2022年海洋天然产物戈登研究会议暨研讨会

基本信息

批准号：
10391748
负责人：
Kerry Leigh McPhail
金额：
$ 2.85万
依托单位：
GORDON RESEARCH CONFERENCES
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-12-15 至 2022-12-14
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10391748
关键词：
Academia Address Affinity Agriculture Anabolism Animals Antimalarials Antiparasitic Agents Area Artemisinins Biological Biological Process Biology Biotechnology California Cells Chemicals Clinical Collaborations Communicable Diseases Complex Complex Mixtures Data Development Discipline Disease Educational workshop Engineering Enhancement Technology Environment Equilibrium Evolution Female Fostering Gender Goals Government Health Hour Human Industrialization Industry Informatics Interdisciplinary Study International Investigation Lead Ligands Machine Learning Malignant Neoplasms Methodology Molecular Molecular Evolution Molecular Genetics Molecular Structure Molecular Target Natural Products Natural Products Chemistry Neurologic Oral Organism Outcome Pain Participant Personal Satisfaction Persons Phenotype Physiology Plants Postdoctoral Fellow Production Research Research Personnel Resolution Science Scientist Signal Pathway Source Structure Students Synthesis Chemistry System Technology Therapeutic Agents Training Translations Underrepresented Minority Underrepresented Populations United States National Institutes of Health Woman Work analytical tool avermectin bioactive natural products biological systems career career development climate change clinical development combat complex biological systems computerized data processing computerized tools data access data integration data tools educational atmosphere experience frontier graduate student human disease innovation inquiry-based learning lens macromolecule marine natural product metabolomics molecular imaging multiple omics nervous system disorder peer posters preclinical development programs scaffold screening social symposium synthetic biology tool training opportunity translation to humans

项目摘要

Project Summary Natural products research has contributed tremendously to human health and well-being, providing unique opportunities in animal health and agriculture as well as human disease treatment, as exemplified by the work of Nobel Laureates Tu Youyou (anti-malarial artemisinin) Satoshi Õmura (anti-parasitic avermectin). The evolution of natural products as potentially multifunctional ligands with highly specific affinities for disease- relevant targets has provided opportunities to develop therapeutic agents for cancers, infectious diseases and neurological disorders in particular. Natural products from the marine environment have provided unique molecular scaffolds that interact with cellular macromolecules and signaling pathways to effect changes in phenotype and physiology distinct from those caused by molecules from other sources. Multi-omics era transformational advances in the molecular genetics of natural product biosynthesis, and analytical technologies for characterizing natural products in the context of complex biological systems, stand to be leveraged further by computational tools that incorporate machine learning for accelerated and early determination of natural product structure and biological function. The 2022 Marine Natural Products Gordon Research Seminar (GRS) and Gordon Research Conference (GRC) is planned for March 6-11, 2022, in Ventura, California. The GRS is a unique forum for graduate students and postdocs to present and exchange new data and innovative ideas across the scope of basic and applied marine natural products research for human health and well-being. The GRC will bring together early career and established researchers from academia, industry, and government (including all of the GRS participants) to address the discovery, characterization and functional development of marine natural products. Presentations and discussion will address the molecular targets of biologically active natural products, including super resolution molecular imaging for natural product mechanisms; computational approaches to functional natural products discovery from complex mixtures; phenotypic screening for natural products discovery, synthetic biology for natural product engineering, synthetic strategies for natural product lead development, marine natural products in clinical development, and climate change and environmental solutions. Graduate students and postdocs will gain experience in poster and oral presentations at the short-format GRS immediately prior to the GRC, and thus be poised to develop career opportunities and new collaborations during the GRC via direct interaction with established leaders in the field. The collegial atmosphere of the GRS and GRC will foster innovative collaborations that bridge scientific disciplines and exchange of ideas among leaders in the field and new participants. NIH support will be directed towards participation of graduate student and postdoctoral presenters and discussion leaders at the GRS and GRC, as well as GRC presenters who are female and or from under-represented groups.

项目摘要天然产品研究为人类健康和福祉做出了巨大贡献，提供了独特的这项工作的例证，动物健康和农业以及人类疾病治疗的机会诺贝尔奖获得者Tu Youyou（抗al虫青蒿素）satoshi市场（抗寄生虫）。这天然产物作为潜在的多功能配体的进化，具有高度特异性的疾病亲和力相关目标为开发癌症，传染病和特别是神经系统疾病。海洋环境的天然产品提供了独特的与细胞大分子和信号通路相互作用的分子支架，以影响变化表型和生理学与其他来源分子引起的不同。多词时代天然产物生物合成和分析技术的分子遗传学的转化进步用于在复杂的生物系统中表征天然产品，以进一步利用合并机器学习的计算工具，以加速和早期确定天然产品结构和生物学功能。 2022年海洋天然产品戈登研究研讨会（GRS）和戈登研究会议（GRC）计划于2022年3月6日至11日在加利福尼亚州的文图拉。 GRS是为研究生和博士后提供独特的论坛，以介绍和交换新的数据和创新想法基本和应用的海洋天然产品研究的范围是人类健康和福祉。 GRC会汇集早期职业和学术界，工业和政府的既定研究人员（包括所有人 GRS参与者）解决海洋自然的发现，表征和功能发展产品。演讲和讨论将解决生物活性天然产物的分子靶标，包括自然产品机制的超级分辨率分子成像；计算方法从复杂混合物中发现功能性天然产品；天然产品的表型筛选发现，自然产品工程的合成生物学，自然产品铅的合成策略开发，临床开发中的海洋天然产品以及气候变化和环境解决方案。研究生和博士后将在短期GRS上获得海报和口头演示的经验紧接GRC之前，因此被毒死以建立职业机会和新的合作 GRC通过与该领域已建立的领导者的直接互动。 GRS和 GRC将促进创新的合作，以弥合领导者之间的科学学科和思想交流在现场和新参与者中。 NIH支持将针对研究生和 GRS和GRC的博士后演示者和讨论领袖以及女性的GRC演示者或来自代表性不足的群体。