2020 Marine Natural Products Gordon Research Conference and Gordon Research Seminar

2020年海洋天然产物戈登研究大会暨戈登研究研讨会

• 批准号: 9907017
• 负责人: Kerry Leigh McPhail
• 金额: $ 2.8万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-12-01 至 2020-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9907017
• 关键词: Academia; Address; Affinity; Anabolism; Area; Basic Science; Bioinformatics; Biological; Biology; California; Cell physiology; Chemicals; Collaborations; Communicable Diseases; Computational Science; Cryoelectron Microscopy; Data; Development; Disabled Persons; Disease; Educational workshop; Environment; Equilibrium; Female; Gender; Gene Cluster; Genetic; Genome; Genomics; Goals; Government; Health; Hour; Human; Individual; Industrialization; Industry; International; Ligands; Malignant Neoplasms; Mass Spectrum Analysis; Medicine; Methodology; Mining; Molecular; Molecular Genetics; Molecular Structure; Molecular Target; Natural Products; Oral; Organism; Outcome; Pain; Participant; Pathway interactions; Phenotype; Physiology; Postdoctoral Fellow; Production; Research; Research Personnel; Roentgen Rays; Role; Science; Scientist; Source; Structure; Students; System; Techniques; Technology; Training; Underrepresented Groups; Underrepresented Minority; United States National Institutes of Health; Woman; Work; bioactive natural products; biological systems; career; career development; clinical application; educational atmosphere; empowerment; experience; graduate student; human disease; immune function; macromolecule; marine natural product; marine organism; meetings; metabolomics; nervous system disorder; new technology; novel; novel strategies; pathogen; posters; preclinical development; programs; scaffold; symposium; therapy design; tool; training opportunity

Project Summary Natural products research is undergoing a transformative period driven by genomics, advances in our understanding of the molecular genetics of natural product biosynthesis, chemical biology solutions to identifying molecular targets and mechanism of action, and new analytical techniques for molecular structure determination. In particular, natural products from marine organisms have delivered unique molecular scaffolds that interact with cellular macromolecules and pathways, altering phenotype and physiology in ways not seen by molecules from other sources. In addition to informing scientists of how biological systems function, the role of natural products as ligands with highly specific affinities for disease-relevant targets has presented opportunities for designing therapies for human disease including cancer, neurological disorders, and many infectious pathogens. With this proposal, support is requested for the 2020 Marine Natural Products Gordon Research Seminar (GRS) and Gordon Research Conference (GRC) to be held in Ventura, California on February 22-28, 2020. The GRS is a unique forum for graduate students and postdocs to present and exchange new data and cutting-edge ideas encompassing the field of marine natural products with applications that range from basic science discoveries to human health impacts. The GRC will bring together early career and established researchers from academia, industry, and government (including all of the GRS participants) to address the discovery, characterization and functional development of marine natural products. Presentations and discussion will focus on how natural products modulate cellular processes and present opportunities to treat human disease; applications of natural product research to medicine and marine conservation; cutting-edge techniques in natural product structure elucidation, synthesis, and determination of modes of action; and the biosynthetic origin of marine natural products including genome mining, heterologous expression, and genetic advances to facilitate the expression of silent gene clusters. Graduate students and postdocs will gain experience in poster and oral presentations at the short-format GRS immediately prior to the GRC, and thus be poised to develop career opportunities and new collaborations during the GRC via direct interaction with established leaders in the field. The collegial atmosphere of the GRS and GRC will facilitate new research directions and training opportunities for early career scientists, and the exchange of ideas among leaders in the field and new participants. NIH support will be directed towards participation of graduate student and postdoctoral presenters and discussion leaders at the GRS and GRC, and female and under-represented minority presenters at the GRC.

项目摘要 天然产品研究正在经历由基因组学驱动的变革时期，我们的进步 了解天然产物生物合成的分子遗传学，化学生物学解决方案 鉴定分子靶标和作用机理，以及分子结构的新分析技术 决心。特别是，来自海洋生物的天然产品提供了独特的分子支架 与细胞大分子和途径相互作用，以未见的方式改变了表型和生理学 通过来自其他来源的分子。除了向科学家告知生物系统的运作方式外 天然产物作为具有高度特异性疾病靶标的配体的配体 设计人类疾病疗法的机会，包括癌症，神经系统疾病和许多 感染性病原体。通过此建议，请求支持2020年海洋天然产品戈登 研究研讨会（GRS）和戈登研究会议（GRC）将于加利福尼亚州的文图拉举行 2020年2月22日至28日。GRS是一个独特的论坛 交换新数据和尖端想法，包括海洋天然产品领域 从基础科学发现到人类健康的影响。 GRC将汇集早期职业 并建立了来自学术界，工业和政府的研究人员（包括所有GRS参与者） 解决海洋天然产品的发现，表征和功能发展。 演示和讨论将集中于天然产品如何调节细胞过程并呈现 治疗人类疾病的机会；自然产品研究在医学和海洋中的应用 保护;自然产品结构中的尖端技术阐明，合成和确定 行动方式；以及海洋天然产品的生物合成起源，包括基因组挖掘，异源 表达和遗传进步，以促进无声基因簇的表达。研究生和 PostDocs将立即在短期GRS的海报和口头演示中获得经验 GRC，因此有望通过直接在GRC期间建立职业机会和新合作 与该领域已建立的领导人的互动。 GRS和GRC的合作气氛将有助于 早期职业科学家的新研究方向和培训机会，以及在 该领域的领导者和新参与者。 NIH支持将针对研究生的参与 以及GRS和GRC的博士后主持人和讨论领袖，女性和代表性不足 GRC的少数派主持人。