2020 Marine Natural Products Gordon Research Conference and Gordon Research Seminar

2020年海洋天然产物戈登研究大会暨戈登研究研讨会

基本信息

批准号：
9907017
负责人：
Kerry Leigh McPhail
金额：
$ 2.8万
依托单位：
GORDON RESEARCH CONFERENCES
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-12-01 至 2020-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9907017
关键词：
Academia Address Affinity Anabolism Area Basic Science Bioinformatics Biological Biology California Cell physiology Chemicals Collaborations Communicable Diseases Computational Science Cryoelectron Microscopy Data Development Disabled Persons Disease Educational workshop Environment Equilibrium Female Gender Gene Cluster Genetic Genome Genomics Goals Government Health Hour Human Individual Industrialization Industry International Ligands Malignant Neoplasms Mass Spectrum Analysis Medicine Methodology Mining Molecular Molecular Genetics Molecular Structure Molecular Target Natural Products Oral Organism Outcome Pain Participant Pathway interactions Phenotype Physiology Postdoctoral Fellow Production Research Research Personnel Roentgen Rays Role Science Scientist Source Structure Students System Techniques Technology Training Underrepresented Groups Underrepresented Minority United States National Institutes of Health Woman Work bioactive natural products biological systems career career development clinical application educational atmosphere empowerment experience graduate student human disease immune function macromolecule marine natural product marine organism meetings metabolomics nervous system disorder new technology novel novel strategies pathogen posters preclinical development programs scaffold symposium therapy design tool training opportunity

项目摘要

Project Summary Natural products research is undergoing a transformative period driven by genomics, advances in our understanding of the molecular genetics of natural product biosynthesis, chemical biology solutions to identifying molecular targets and mechanism of action, and new analytical techniques for molecular structure determination. In particular, natural products from marine organisms have delivered unique molecular scaffolds that interact with cellular macromolecules and pathways, altering phenotype and physiology in ways not seen by molecules from other sources. In addition to informing scientists of how biological systems function, the role of natural products as ligands with highly specific affinities for disease-relevant targets has presented opportunities for designing therapies for human disease including cancer, neurological disorders, and many infectious pathogens. With this proposal, support is requested for the 2020 Marine Natural Products Gordon Research Seminar (GRS) and Gordon Research Conference (GRC) to be held in Ventura, California on February 22-28, 2020. The GRS is a unique forum for graduate students and postdocs to present and exchange new data and cutting-edge ideas encompassing the field of marine natural products with applications that range from basic science discoveries to human health impacts. The GRC will bring together early career and established researchers from academia, industry, and government (including all of the GRS participants) to address the discovery, characterization and functional development of marine natural products. Presentations and discussion will focus on how natural products modulate cellular processes and present opportunities to treat human disease; applications of natural product research to medicine and marine conservation; cutting-edge techniques in natural product structure elucidation, synthesis, and determination of modes of action; and the biosynthetic origin of marine natural products including genome mining, heterologous expression, and genetic advances to facilitate the expression of silent gene clusters. Graduate students and postdocs will gain experience in poster and oral presentations at the short-format GRS immediately prior to the GRC, and thus be poised to develop career opportunities and new collaborations during the GRC via direct interaction with established leaders in the field. The collegial atmosphere of the GRS and GRC will facilitate new research directions and training opportunities for early career scientists, and the exchange of ideas among leaders in the field and new participants. NIH support will be directed towards participation of graduate student and postdoctoral presenters and discussion leaders at the GRS and GRC, and female and under-represented minority presenters at the GRC.

项目概要天然产物研究正在经历一个由基因组学、我们的进步推动的变革时期了解天然产物生物合成的分子遗传学、化学生物学解决方案识别分子靶点和作用机制，以及分子结构的新分析技术决心。特别是，来自海洋生物的天然产物提供了独特的分子支架与细胞大分子和通路相互作用，以前所未见的方式改变表型和生理学来自其他来源的分子。除了让科学家了解生物系统如何运作之外，它的作用天然产物作为对疾病相关靶点具有高度特异性亲和力的配体的研究已提出设计针对人类疾病（包括癌症、神经系统疾病和许多疾病）的疗法的机会传染性病原体。在此提案中，请求支持 2020 年海洋天然产品戈登研究研讨会（GRS）和戈登研究会议（GRC）将于2017年在加利福尼亚州文图拉举行 2020 年 2 月 22 日至 28 日。GRS 是研究生和博士后展示和展示成果的独特论坛交流海洋天然产物及其应用领域的新数据和前沿思想其范围从基础科学发现到人类健康影响。 GRC 将汇集早期职业生涯以及来自学术界、工业界和政府的知名研究人员（包括所有 GRS 参与者）解决海洋天然产品的发现、表征和功能开发问题。演示和讨论将重点关注天然产品如何调节细胞过程并呈现治疗人类疾病的机会；天然产物研究在医学和海洋中的应用保护;天然产物结构解析、合成和测定的尖端技术行动方式；以及海洋天然产物的生物合成起源，包括基因组挖掘、异源表达和遗传进展以促进沉默基因簇的表达。研究生和博士后将在会议之前在简短的 GRS 中获得海报和口头演示的经验 GRC，从而准备在 GRC 期间通过直接方式发展职业机会和新的合作与该领域的知名领导者进行互动。 GRS 和 GRC 的学院氛围将促进为早期职业科学家提供新的研究方向和培训机会，以及相互之间的思想交流该领域的领导者和新参与者。 NIH 支持将针对研究生的参与 GRS 和 GRC 的博士后演讲者和讨论领袖，以及女性和代表性不足的人 GRC 的少数族裔演讲者。