Accelerating nerve regeneration with botulinum toxin and electrical stimulation therapies

通过肉毒杆菌毒素和电刺激疗法加速神经再生

• 批准号: 10383674
• 负责人: Colin Franz
• 金额: $ 16.18万
• 依托单位: REHABILITATION INSTITUTE OF CHICAGO D/B/A SHIRLEY RYAN ABILITYLAB
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-04-05 至 2024-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10383674
• 关键词: Acute; Address; Adult; Anatomy; Axon; Behavior; Botulinum Toxin Type A; Botulinum Toxins; Clinic; Clinical; Clinical Research; Clinical Trials; Distal; Dose; Electric Stimulation; Electric Stimulation Therapy; Electrophysiology (science); Event; FDA approved; Foundations; Fracture; Future; Goals; Gunshot wound; Human; Implant; In Vitro; Incidence; Injury; Intramuscular Injections; Left; Lesion; Limb structure; Measures; Modeling; Monitor; Muscle; Natural regeneration; Nerve; Nerve Crush; Nerve Regeneration; Neurons; Operative Surgical Procedures; Organ; Outcome; Paralysed; Pathway interactions; Patients; Peripheral nerve injury; Pharmaceutical Preparations; Phase; Postoperative Period; Process; Proteins; Protocols documentation; Public Health; Randomized Clinical Trials; Recovery; Recovery of Function; Rehabilitation therapy; Rodent; Scientist; Site; Skin; Speed; Structure of tibial nerve; Subgroup; System; Technology; Testing; Time; Tracer; Transgenic Mice; Trauma; Visualization; Work; axon regeneration; base; clinical implementation; clinically relevant; drug repurposing; experimental study; follow-up; functional disability; functional outcomes; hip bone; hip replacement arthroplasty; improved; in vivo; limb amputation; muscle reinnervation; nerve gap; nerve injury; nerve repair; neuromuscular; novel; novel therapeutics; open wound; painful neuropathy; repair model; repaired; sciatic nerve lesion; treatment strategy; wireless

Project Summary Peripheral nerve injuries are an under-appreciated public health problem. There are about 200,000 new cases per year in the USA. Recovery is incomplete for the vast majority of patients who suffer from one because nerve regrowth is slow and inefficient. Unfortunately, there are no approved treatments to improve the process of nerve regeneration. We have identified two complimentary therapies in order to target the (i) early and (ii) late phases of the nerve regeneration process. They each may work as stand-alone therapy or potentially in combination, as we predict they will have an additive benefit on nerve repair. The present proposal will set the stage for a follow up clinical trial to bring the most promising therapy to patients. We believe we can make rapid progress towards this goal because one therapy represents a repurposing of an already FDA-approved drug, and the other therapy is a form of electrical stimulation that already has shown efficacy in small clinical trials for nerve injury. The electrical stimulation therapy is in need of a new mode of delivery to remove barriers to clinical implementation, which we offer by means of novel transient bio-electric implant system. Overall, this proposal will deliver a new horizon in how we can improve the treatment of patients with peripheral nerve injuries to maximize their functional recovery.

项目概要 周围神经损伤是一个未被充分认识的公共卫生问题。有大约 美国每年新增病例 20 万例。绝大多数患者的康复并不完全 由于神经再生缓慢且效率低下而患有这种疾病的人。不幸的是，没有 批准的治疗方法可改善神经再生过程。我们已经确定了两个 补充疗法，以针对 (i) 神经的早期阶段和 (ii) 晚期阶段 再生过程。它们各自可以作为独立疗法或潜在地用于 结合起来，正如我们预测的那样，它们将对神经修复产生额外的好处。现在的 该提案将为后续临床试验奠定基础，以将最有希望的治疗方法带入 患者。我们相信我们可以在实现这一目标方面取得快速进展，因为一种疗法 代表了 FDA 批准的药物的重新利用，而另一种疗法是一种形式 电刺激已经在神经损伤的小型临床试验中显示出疗效。这 电刺激疗法需要一种新的传递方式来消除临床障碍 我们通过新型瞬态生物电植入系统提供实施。全面的， 该提案将为我们如何改善患有糖尿病的患者的治疗提供新的视野 周围神经损伤最大限度地恢复其功能。

项目成果

Implantation and Control of Wireless, Battery-free Systems for Peripheral Nerve Interfacing.

• DOI: 10.3791/63085
• 发表时间: 2021-10-20
• 期刊: Journal of visualized experiments : JoVE
• 作者: Wang H;D'Andrea D;Choi YS;Bouricha Y;Wickerson G;Ahn HY;Guo H;Huang Y;Sandhu MS;Jordan SW;Rogers JA;Franz CK
• 通讯作者: Franz CK

Advanced Materials in Wireless, Implantable Electrical Stimulators that Offer Rapid Rates of Bioresorption for Peripheral Axon Regeneration

• DOI: 10.1002/adfm.202102724
• 发表时间: 2021-05-06
• 期刊: ADVANCED FUNCTIONAL MATERIALS
• 影响因子: 19
• 作者: Guo, Hexia;D'Andrea, Dom;Rogers, John A.
• 通讯作者: Rogers, John A.