Core 1: Administrative Core

核心 1：行政核心

基本信息

批准号：
10471453
负责人：
Maria Mori Brooks
金额：
$ 123.46万
依托单位：
UNIVERSITY OF PITTSBURGH AT PITTSBURGH
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-09-30 至 2025-02-28
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10471453
关键词：
Activities of Daily Living Affect Age Age-Years Aging Alzheimer&apos s Disease Alzheimer&apos s disease related dementia Ancillary Study Cardiac health Cardiovascular Diseases Characteristics Clinical Communication Communities Country Creativeness Data Data Collection Databases Dementia Disease Doctor of Philosophy Educational workshop Elderly Enrollment Ensure Epidemiology Event Follow-Up Studies Fostering Foundations Future Genitourinary system Health Health Personnel Impaired cognition Impairment Incidence Infrastructure Institution Institutional Review Boards Intervention Investigation Joints K-Series Research Career Programs Laboratories Lead Leadership Life Life Experience Link Longevity Longitudinal Studies Longitudinal cohort study Manuscripts Measures Menopause Methods Monitor Musculoskeletal Observational Study Outcome Participant Perimenopause Physical Function Physiological Prevention Productivity Public Health Schools Publications Quality of life Reporting Research Research Design Research Personnel Research Support Resources Risk Factors Role Science Secure Sex Functioning Site Sleep disturbances Strategic Planning Structure Study of Women&apos s Health Across the Nation System Testing Translating Translations United States Universities Vascular Dementia Visit Woman Women&apos s Health Work Writing age related base career development clinical practice clinical research site clinically relevant cognitive function cohort critical period data centers dementia risk design disability epidemiologic data follow-up heart function human old age (65+)innovation investigator training middle age mild cognitive impairment modifiable risk multi-racial multiple chronic conditions novel operation organizational structure participant retention participant safety physical conditioning physically handicapped preservation psychosocial racial and ethnic research study socioeconomics success welfare

项目摘要

SWAN-Aging is designed to determine the extent to which midlife health and characteristics of the menopause transition (MT) affect successful aging in women, including the rate of cognitive decline and the risk of dementia and disability. Studies on aging highlight the midlife (age 40-65 years) as a critical life stage for prevention of cognitive impairment, Alzheimer’s disease, Alzheimer’s disease related dementia, physical disability and multi-morbidity in old age. This U19 proposal will extend follow-up of the Study of Women’s Health Across the Nation (SWAN), a longitudinal study initiated in 1994 to characterize the physiological and psychosocial changes that occur during the MT, into early old age (66-75 years). It will expand data collection to link midlife health characteristics and modifiable risk factors to early and rapid cognitive decline, incidence of mild cognitive impairment, cardiac health, and physical function in early old age. SWAN-Aging will leverage the existing SWAN scientific expertise and organizational structure to create three integrated Projects. Project 1 will evaluate the impact of MT characteristics and midlife health indicators on preservation of cognitive function (avoiding cognitive decline and onset of mild cognitive impairment), sleep, genitourinary and sexual function, and quality of life in early old age; Project 2 will test how the MT relates to cardiac health and cardiovascular disease (CVD) events in women in early old age and test how cardiac health relates to early markers of physical impairment, Alzheimer’s disease, and vascular dementia at a critical period in the lifespan; and Project 3 will examine the role of the MT and midlife characteristics on musculoskeletal health and physical functioning. The specific aims of Administrative Core (Core 1) are to: 1) Provide leadership, strategic planning, and organizational infrastructure for SWAN-Aging; 2) Facilitate investigator interaction, creativity, and productivity; 3) Disseminate SWAN and SWAN-Aging results and enhance translation; 4) Ensure broad use of SWAN data and support career development; and 5) Monitor and protect participant safety. Core 1 will coordinate and support research efforts across the Projects and Cores and will supply the required resources to execute study operations. Core 1 will support an Integrative Sciences Committee that will facilitate cross-cutting investigations of the interrelationships between cognitive, cardiac, and physical function, and their joint impact on activities of daily living disability. Core 1 will also lead a new Translation and Dissemination Committee in which experts in women’s health will develop methods for disseminating rigorous research results focused on the enhancement of physical health and the prevention of dementia and disability for clinical and lay communities. The Administrative Core will provide the structure required for the SWAN-Aging Projects to successfully conduct their studies, produce meaningful research results, and translate clinically relevant findings to facilitate identification of midlife prevention targets to delay or avoid mild cognitive impairment, preserve functioning, maintain independence, and optimize quality of life in early old age.

SWAN-Aging 旨在确定中年健康和更年期过渡 (MT) 特征对女性成功老龄化的影响程度，包括认知能力下降的速度以及痴呆和残疾的风险。 40-65岁）作为预防认知障碍、阿尔茨海默病、阿尔茨海默病相关痴呆、身体残疾和老年多种疾病的关键生命阶段。这项U19提案将延长女性健康研究的后续工作。全国范围 (SWAN) 是一项于 1994 年启动的纵向研究，旨在描述 MT 期间到老年早期（66-75 岁）发生的生理和心理变化，它将扩大数据收集范围，将中年健康特征和可改变的风险联系起来。 SWAN-Aging 将利用现有的 SWAN 科学专业知识和组织结构来创建三个综合项目，项目 1 将评估其影响。的MT 特征和中年健康指标，涉及认知功能的保存（避免认知能力下降和轻度认知障碍的发生）、睡眠、泌尿生殖和性功能以及早年生活质量；项目 2 将测试 MT 与心脏健康的关系；老年妇女的心血管疾病 (CVD) 事件，并测试心脏健康与生命周期关键时期身体损伤、阿尔茨海默氏病和血管性痴呆的早期标志物之间的关系，项目 3 将研究心脏健康的作用； MT 和中年特征对肌肉骨骼健康和身体功能的影响管理核心（核心 1）的具体目标是： 1) 为 SWAN-Aging 提供领导力、战略规划和组织基础设施； 2) 促进研究者的互动、创造力和生产力。 3) 传播 SWAN 和 SWAN-Aging 结果并加强翻译； 4) 确保 SWAN 数据的广泛使用并支持职业发展；以及 5) 监控和保护参与者的安全。 1 将协调和支持跨项目和核心的研究工作，并将提供执行研究操作所需的资源。核心 1 将支持综合科学委员会，该委员会将促进认知、心脏和身体功能之间相互关系的跨领域调查。核心 1 还将领导一个新的翻译和传播委员会，其中妇女健康专家将制定传播严格研究成果的方法，重点是增强身体健康和预防痴呆和残疾。行政核心将为 SWAN-Aging 项目提供成功开展研究、产生有意义的研究结果并转化临床相关发现以促进确定中年预防目标以延迟或避免轻度认知障碍所需的结构。、保持功能、保持独立并优化老年早期的生活质量。