Core 3: Data Collection & Data Management Core

核心 3：数据收集

• 批准号: 10263897
• 负责人: Maria Mori Brooks
• 金额: $ 429.92万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-30 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10263897
• 关键词: Affect; Aging; Alzheimer' s Disease; Archives; Cardiac; Cardiac health; Cardiovascular Diseases; Characteristics; Clinical; Clinical Data; Cognition; Cognitive; Cognitive deficits; Collection; Data; Data Collection; Data Set; Dementia; Disease; Doctor of Philosophy; Educational workshop; Elderly; Enrollment; Ensure; Event; Follow-Up Studies; Genitourinary system; Goals; Health; Health behavior; Heart failure; Hormones; Human Resources; Impaired cognition; Impairment; Incentives; Incidence; Infrastructure; Laboratories; Language; Lead; Leadership; Life Experience; Link; Longevity; Longitudinal Studies; Longitudinal cohort study; Manuscripts; Measures; Menopause; Monitor; Musculoskeletal; Participant; Physical Function; Physiological; Play; Process; Protocols documentation; Public Health Schools; Quality Control; Quality of life; Reading; Research; Research Personnel; Resources; Risk Factors; Role; Services; Sex Functioning; Sexual Health; Site; Sleep; Sleep disturbances; Specimen; Structure; Study of Women' s Health Across the Nation; Symptoms; Technology; Testing; Training; Universities; Vagina; Vascular Dementia; Vasomotor; Visit; Visuospatial; Well in self; Woman; Women' s Health; Work; actigraphy; age related; bone; cardiometabolism; cardiovascular health; clinical research site; cognitive function; cognitive performance; cohort; critical period; data centers; data management; dementia risk; design; disability; epidemiologic data; experience; follow-up; human old age (65+); improved; instrumental activity of daily living; middle age; mild cognitive impairment; modifiable risk; multi-racial; participant retention; pre-clinical; preservation; psychosocial; racial and ethnic; retention rate; sedentary lifestyle; socioeconomics; success; Affect; Aging; Alzheimer' s Disease; Archives; Cardiac; Cardiac health; Cardiovascular Diseases; Characteristics; Clinical; Clinical Data; Cognition; Cognitive; Cognitive deficits; Collection; Data; Data Collection; Data Set; Dementia; Disease; Doctor of Philosophy; Educational workshop; Elderly; Enrollment; Ensure; Event; Follow-Up Studies; Genitourinary system; Goals; Health; Health behavior; Heart failure; Hormones; Human Resources; Impaired cognition; Impairment; Incentives; Incidence; Infrastructure; Laboratories; Language; Lead; Leadership; Life Experience; Link; Longevity; Longitudinal Studies; Longitudinal cohort study; Manuscripts; Measures; Menopause; Monitor; Musculoskeletal; Participant; Physical Function; Physiological; Play; Process; Protocols documentation; Public Health Schools; Quality Control; Quality of life; Reading; Research; Research Personnel; Resources; Risk Factors; Role; Services; Sex Functioning; Sexual Health; Site; Sleep; Sleep disturbances; Specimen; Structure; Study of Women' s Health Across the Nation; Symptoms; Technology; Testing; Training; Universities; Vagina; Vascular Dementia; Vasomotor; Visit; Visuospatial; Well in self; Woman; Women' s Health; Work; actigraphy; age related; bone; cardiometabolism; cardiovascular health; clinical research site; cognitive function; cognitive performance; cohort; critical period; data centers; data management; dementia risk; design; disability; epidemiologic data; experience; follow-up; human old age (65+); improved; instrumental activity of daily living; middle age; mild cognitive impairment; modifiable risk; multi-racial; participant retention; pre-clinical; preservation; psychosocial; racial and ethnic; retention rate; sedentary lifestyle; socioeconomics; success

SWAN-Aging is designed to determine the extent to which midlife health and characteristics of the menopause transition (MT) affect successful aging in women, including the rate of cognitive decline and the risk of dementia and disability. This application proposes to build upon the rich resources of the Study of Women’s Health Across the Nation (SWAN), a longitudinal cohort study initiated in 1994 to characterize the physiological and psychosocial changes that occur during the MT. In SWAN-Aging, we will extend follow-up of the SWAN cohort into early old age (66-75 years) and expand data collection to include additional domains of cognition to detect cognitive impairment (executive and visual-spatial function, language fluency) and the functional impact of cognitive deficits (cognitively demanding instrumental activities of daily living), cardiac health, and sedentary behavior. It is one of a few studies that can quantify the rate of decline in cognitive performance during midlife and early old age and determine the contribution of modifiable risk factors to the incidence of mild cognitive impairment. SWAN-Aging includes three integrated Projects: Project 1 will evaluate the impact of MT characteristics and midlife health indicators on preservation of cognitive function (avoiding cognitive decline and onset of mild cognitive impairment), sleep, genitourinary and sexual function, and quality of life in early old age; Project 2 will test how the MT relates to cardiac health and cardiovascular disease (CVD) events in women in early old age and test how cardiac health relates to early markers of physical impairment, Alzheimer’s disease, and vascular dementia at a critical period in the lifespan; and Project 3 will examine the role of MT and midlife characteristics on musculoskeletal health and physical functioning. The specific aims of Data Collection and Data Management Core (Core 3) are to: 1) Maintain excellent retention of study participants at all clinical sites; 2) Finalize the participant visit protocol and ensure the collection of high quality data from the clinical sites and reading centers; 3) Implement effective quality control measures and provide analytic datasets to study investigators; and 4) Archive and share the SWAN-Aging data. Core 3 will work with the clinical sites to employ effective strategies to maintain SWAN’s high participant retention rate and develop clear, detailed protocols, on-site personnel trainings and quality control measures to monitor the collection of data and specimens. Core 3 will build on the strengths of the existing SWAN data management structure and incorporate improved technology to improve the efficiency of quality control processes. Core 3 will construct datasets to facilitate a variety of analytic strategies to comprehensively assess the role of MT and midlife factors on cognitive decline, cardiac health and physical functioning and will archive de-identified datasets for public use. Core 3 will play a vital role in conducting the Projects by supporting retention and data collection and ensuring that study data will be high quality and used to identify modifiable factors linked to avoidance of mild cognitive impairment, preservation of functioning, and optimization of quality of life in early old age.

天鹅衰老旨在确定中年健康和更年期过渡（MT）的特征的程度，影响女性的成功衰老，包括认知能力下降的速度以及痴呆症和残疾的风险。这项申请提出的建议是基于全国妇女健康研究的丰富资源（SWAN），这是一项纵向队列研究，于1994年启动，旨在表征MT期间发生的身体和社会心理变化。在天鹅范围内，我们将将天鹅队列的随访扩展到早期（66 - 75年），并扩大数据收集，以包括其他认知领域，以检测认知障碍（执行和视觉空间功能，语言流畅性）和认知能力的功能影响（认知能力障碍的功能影响）（认知要求对日常生活的良好生活）和耐心的健康，既需态度又有良好的健康。这是一些可以量化中年和老年认知表现下降率的研究之一，并确定可修改的危险因素对轻度认知障碍发生率的贡献。 Swan-Aging包括三个综合项目：项目1将评估MT特征和中年健康指标对保存认知功能（避免认知能力下降和轻度认知障碍的发作）的影响，睡眠，刚关节和性功能以及早期的生活质量；项目2将测试MT在老年妇女中与心脏健康和心血管疾病（CVD）事件的关系，并测试心脏健康与生理障碍，阿尔茨海默氏病和血管性痴呆的早期标志与生命周期的关键时期有关；项目3将研究MT和中年特征在肌肉骨骼健康和身体功能方面的作用。数据收集和数据管理核心的具体目的（核心3）是：1）在所有临床部位保持研究参与者的出色保留； 2）最终确定参与方案，并确保从临床站点和阅读中心收集高质量的数据； 3）实施有效的质量控制措施并提供分析数据集来研究研究人员； 4）存档并共享天鹅的数据。 Core 3将与临床站点合作，以保持有效的策略，以维持天鹅的高参与率保留率，并制定清晰，详细的协议，现场人员培训和质量控制措施，以监视数据和规格的收集。 Core 3将基于现有的天鹅数据管理结构的优势，并融合了提高质量控制过程效率的技术。 Core 3将构建数据集，以促进各种分析策略，以全面评估MT和中年因素对认知能力下降，心脏健康和身体功能的作用，并将归类于公共使用的数据集。 Core 3将通过支持保留和数据收集，并确保研究数据将是高质量的，并用于确定与避免轻度认知障碍，功能性的保存以及早期的生活质量优化的可修改因素，将发挥至关重要的作用。