Neuroimaging Core

神经影像核心

• 批准号: 10456750
• 负责人: PAUL M THOMPSON
• 金额: $ 50.97万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-07-01 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10456750
• 关键词: Aging; Air Pollutants; Air Pollution; Alzheimer' s Disease; Alzheimer' s disease brain; Alzheimer' s disease risk; American; Amygdaloid structure; Amyloid; Angiography; Animals; Anisotropy; Autopsy; Blood - brain barrier anatomy; Blood Vessels; Brain; Brain imaging; Brain region; Cerebrovascular Circulation; Clinical; Cognition; Cognitive; Cognitive aging; Computer software; Confocal Microscopy; Data; Data Analyses; Diffuse; Diffusion Magnetic Resonance Imaging; Disease; Episodic memory; Equation; Experimental Animal Model; Exposure to; Heterogeneity; Hippocampus (Brain); Human; Image; Image Analysis; Immunofluorescence Microscopy; Impaired cognition; Injury; Lead; MRI Scans; Machine Learning; Magnetic Resonance Imaging; Maps; Measures; Medial; Mediating; Mediation; Mission; Modeling; Mus; Nerve Degeneration; Participant; Pattern; Population; Population Study; Radial; Research; Research Personnel; Risk; Scanning; Scientist; Standardization; Structure; Temporal Lobe; Testing; Thick; Time; Validation; White Matter Hyperintensity; Work; arterial spin labeling; base; biomarker signature; blood-brain barrier permeabilization; brain magnetic resonance imaging; cerebrovascular; cohort; contrast enhanced; data standards; dimensional analysis; executive function; follow-up; frontal lobe; high dimensionality; in vivo; magnetic resonance imaging biomarker; mild cognitive impairment; neuroimaging; neurovascular unit; novel; pre-clinical; prospective; response; tau Proteins; tool; tractography; trait; white matter

Abstract Core B The Imaging Core B (Paul Thompson, Director) provides brain image analysis for Projects 1-4, which analyze neurodegenerative responses to air pollution. Sub-core B1 (M. Braskie) supports Projects 1 and 2 on human brain MR images. Sub-core B2 (B. Zlokovic) supports Projects 3 and 4 on mouse brain. Sub-core B1 Human Neuroimaging Aim 1: Perform standardized structural image analyses in the ADNI, WHIMS and VETSA cohorts to assess voxelwise cortical thickness, volumes of selected Alzheimer's disease (AD)-relevant subcortical structures (hippocampus and amygdala), and regional white matter using FreeSurfer software. We will also assess white matter hyperintensity volumes. In ADNI and VETSA we will analyze diffusion tensor imaging scans. Aim 2: Use machine learning to generate structural MRI cortical signatures and associated predicted risk scores related to risk for preclinical AD, mild cognitive impairment, and AD. Aim 3: Support Projects 1 & 2 in their proposed mediation analyses using both targeted approach in structural equation models (SEM) and agnostic approach with high-dimensional analyses. Sub-Core B2, Mouse brain imaging. Aim 1. Perform in vivo mouse brain imaging to assess cerebral blood flow, blood brain barrier (BBB) permeability, vascular angiography, and MRI tractography. Aim 2. Postmortem studies of the neurovascular unit & BBB by confocal microscopy for immunofluorescence. Aim 3. Ultra-highfield MRI to detect mouse connectivity changes through diffusivity and tractography maps & quantification of BBB permeability by dynamic contrast enhanced (DCE)-MRI. Aim 4 Analyze mouse data from Projects 3 and 4.

抽象核心b Imaging Core B（Paul Thompson，董事）为项目1-4提供了大脑图像分析，该项目分析了 神经退行性对空气污染的反应。亚核B1（M. Braskie）支持人类的项目1和2 脑MR图像。亚核B2（B. Zlokovic）支持小鼠大脑的项目3和4。 亚核B1人神经影像学 目标1：在ADNI，WHIMS和VETSA队列中进行标准化的结构图像分析以评估 体素的皮质厚度，选定阿尔茨海默氏病（AD）的体积 - 皮层下层结构 （海马和杏仁核），以及使用FreeSurfer软件的区域白质。我们还将评估白色 物质高强度体积。在ADNI和VETSA中，我们将分析扩散张量成像扫描。 目标2：使用机器学习来产生结构性MRI皮质签名和相关的预测风险 与临床前广告，轻度认知障碍和AD的风险有关的分数。 AIM 3：在他们提出的调解分析中使用两种有针对性方法的结构中的拟议调解分析中支持项目1和2 具有高维分析的方程模型（SEM）和不可知的方法。 亚核B2，小鼠脑成像。 目标1。进行体内小鼠脑成像以评估脑血流，血脑屏障（BBB） 渗透性，血管血管造影和MRI拖拉学。 AIM 2。通过共聚焦显微镜进行免疫荧光的神经血管单元和BBB的死后研究。 AIM 3。超高场MRI，通过扩散性和拖拉图图检测小鼠连通性的变化＆ 通过动态对比度增强（DCE）-MRI对BBB渗透性进行定量。 AIM 4分析项目3和4的鼠标数据。