MIRDCalc – A Community Tool for Deriving and Reporting Patient Organ Doses in Nuclear Medicine, Computed Tomography, and Hybrid Imaging

MIRDCalc — 用于导出和报告核医学、计算机断层扫描和混合成像中患者器官剂量的社区工具

• 批准号: 10456116
• 负责人: WESLEY E BOLCH
• 金额: $ 62.22万
• 依托单位: SLOAN-KETTERING INST CAN RESEARCH
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-13 至 2024-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10456116
• 关键词: Address; Adoption; Animals; Architecture; Archives; Back; Benefits and Risks; Big Data; Biodistribution; Biomedical Research; Childhood; Clinical; Clinical Research; Code; Communities; Complex; Computed Tomography Scanners; Computer software; Costs and Benefits; Data; Databases; Derivation procedure; Detection; Development; Diagnostic; Diagnostic Imaging; Diagnostic radiologic examination; Digital Imaging and Communications in Medicine; Discipline of Nuclear Medicine; Disease; Documentation; Dose; Evidence Based Medicine; FDA approved; Feedback; Florida; Future; Generations; Growth; Health; Healthcare; Hybrids; Image; Imaging Techniques; Infrastructure; Institution; Isotopes; Libraries; Low Dose Radiation; Malignant Neoplasms; Medical; Medical Imaging; Modality; Modeling; Modernization; Monte Carlo Method; Nuclear; Online Systems; Organ; Outcome; Patient Care; Patients; Penetration; Physics; Play; Population; Positron-Emission Tomography; Procedures; Protocols documentation; Radiation; Radiation Dose Unit; Radiation therapy; Radioisotopes; Radiology Specialty; Radiopharmaceuticals; Reporting; Reproducibility; Research; Resources; Risk Assessment; Roentgen Rays; Role; Series; Site; Software Design; Software Tools; Source; Standardization; System; Techniques; Testing; Therapeutic; Therapy trial; Time; Uncertainty; Universities; Update; X-Ray Computed Tomography; base; cancer therapy; clinical decision-making; cost; design; dosimetry; epidemiology study; image archival system; improved; innovation; molecular imaging; molecular targeted therapies; multidisciplinary; nuclear imaging; patient population; personalized medicine; response; risk minimization; simulation; single photon emission computed tomography; tool; treatment optimization; tumor

Project Summary The assessment of radiation organ absorbed dose to patients plays a critical role in both the development and clinical use of radiopharmaceuticals for both diagnostic imaging (cancer/disease detection) and radiation therapy (cancer treatment). Dosimetry also provides the basis of imaging/treatment optimization, and its accessibility and maturation will help define personalized medicine as applied to medical imaging and nuclear therapies in the coming decades. A variety of software codes exist for patient dosimetry in nuclear medicine, but they tend to reside within two extremes of functionality. At one end are more simplistic NM dosimetry tools that merge animal- derived or personalized biodistribution data with standard (population-averaged) models, a technique that has proved valuable historically but has seen minimal technological advancement. At the other end are complex NM dosimetry codes that import patient-specific CT/PET/SPECT images and allow for accurate, but computationally intensive, Monte Carlo simulation-based dosimetry. The issue with these higher-end codes is that they are much more nuanced, resource intensive, and tend to only reside within research-based medical institutions with expert support staff. In this Biomedical Research Partnership between MSK and UF, a new generation of nuclear medicine patient dosimetry code will be developed and released at no cost to the imaging and clinical community. The code – MIRDcalc – is built upon the universally available Microsoft Excel platform and can be used with an easy interactive interface or automated DOS command line. The database powering MIRDcalc stores all necessary information for implementing biodistribution-to-dosimetry calculations using the MIRD schema. The current generation of MIRDcalc thus will not include acquisition and derivation of the input time-activity data, which is beyond the scope of the current application, but will be incorporated into future versions of this code. It includes radionuclide S values for 333 radioisotopes, associated with 12 modern ICRP reference phantoms each with 58 source organs and 44 target organs and is readily expandable to accommodate additional isotopes and phantoms. The MIRDcalc software will be a free tool providing dosimetry that meets current standards, and a platform for further innovations as well as a central framework for supporting a dosimetry user community. Our planned innovations address issues of personalization, uncertainty calculation, documentation, and other key considerations. Of note, and a key feature of this partnership, is the addition of CT organ dosimetry to MIRDcalc, which presently does not exist in any current nuclear medicine software code despite the universal adoption of combination PET-CT and the ever-increasing penetration of SPECT-CT scanners in diagnostic radiology and nuclear medicine.

项目摘要 辐射器官吸收剂量的患者的评估在发育和 放射性药物用于诊断成像（癌症/疾病检测）和放射疗法的临床使用 （癌症治疗）。剂量测定还提供了成像/处理优化的基础，以及其可访问性和 成熟将有助于定义个性化医学，以适用于医学成像和核疗法 未来几十年。有多种软件代码用于核医学中的患者剂量法，但它们倾向于 驻留在两个极端功能之内。一方面是更简单的NM剂量测定工具，可以合并动物 - 带有标准（人口平均）模型的派生或个性化生物分布数据，该技术具有 历史上被证明是有价值的，但技术进步很小。另一端是复杂的NM 剂量计的代码，这些代码会导入患者特定的CT/PET/SPECT图像，并允许准确但计算 密集的，蒙特卡洛模拟的剂量法。这些高端代码的问题是它们很大 更细微的，资源密集，倾向于与专家一起居住在基于研究的医疗机构中 支持人员。 在新一代核医学患者的生物医学研究伙伴关系中 剂量法定代码将免费开发和发布成像和临床社区。代码 - MirdCalc - 建立在普遍可用的Microsoft Excel平台上，可与 交互式接口或自动DOS命令行。供电Mirdcalc的数据库存储所有必要的 用于使用Mird模式实施生物分布到毫无术计算的信息。电流 因此，MIRDCALC的产生将不包括获取和输入时间活性数据的衍生 除了当前应用程序的范围之外，但将被整合到本代码的未来版本中。它包括 333个放射性同位素的放射性s值，与12个现代ICRP参考幻影相关 来源器官和44个目标器官，很容易扩展以适应其他同位素和 幻影。 Mirdcalc软件将是一个免费的工具，可提供符合当前标准的剂量测定法，以及一个平台 进一步的创新以及支持剂量计用户社区的中心框架。我们的计划 创新解决了个性化，不确定性计算，文档和其他密钥的问题 考虑因素。值得注意的是，这种合作伙伴关系的关键特征是将CT器官剂量添加到Mirdcalc， 目前在任何当前的核医学软件代码目的地目的地都不存在的普遍采用 PET-CT的组合以及Spect-CT扫描仪在诊断放射学和 核医学。