Spatiotemporal organization of the inferior frontal gyrus during speech production - Resubmission - 1

言语产生过程中额下回的时空组织 - 重新提交 - 1

• 批准号: 10369007
• 负责人: Adeen Flinker
• 金额: $ 56.45万
• 依托单位: NEW YORK UNIVERSITY SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-05-15 至 2024-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10369007
• 关键词: Address; Anatomy; Anterior; Articulation; Articulators; Behavior; Bilateral; Biological Assay; Broca Aphasia; Broca' s area; Clinical; Data; Electric Stimulation; Electrocorticogram; Electrodes; Etiology; Goals; Human; Impairment; Inferior frontal gyrus; Knowledge; Language; Left; Lesion; Maps; Measurement; Measures; Medical center; Middle Inferior Frontal Convolution; Mutism; Names; New York; Operative Surgical Procedures; Outcome Study; Output; Patients; Physical shape; Probability; Production; Research Personnel; Resolution; Resources; Retrieval; Role; Sampling; Semantics; Site; Spatial Distribution; Specificity; Speech; Speech Disorders; Surface; Techniques; Testing; Time; Traction; Universities; cognitive task; cohort; density; design; frontal lobe; improved; neuroimaging; neurophysiology; neurotransmission; novel therapeutic intervention; prevent; relating to nervous system; response; semantic processing; simulation; spatiotemporal; trait

Project Summary Speech is a uniquely human trait that is central to our everyday lives, but the mechanisms that enable retrieval and formation of articulatory sequences remain elusive. Several lines of evidence suggest that the left inferior frontal gyrus (IFG), or Broca’s region, is active prior to articulation per se and critically supports articulatory planning. However, it remains unclear how different anatomical parcellations of IFG support retrieval of semantic information and articulatory planning. To investigate this issue, we will leverage resources at NYU, assembling clinicians and researchers with complementary expertise to reexamine the role of the IFG in speech. We propose working in a cohort of neurosurgical patients who provide a rare and unique opportunity to collect direct cortical recordings and perturbations during speech production. Specifically, we will address the following questions: (1) what is the time constant of neural responses across IFG in relation to speech production, (2) what is the functional specificity of IFG regions, pars opercularis and pars triangularis, and (3) what are the functional boundaries Broca’s territory across the left and right frontal cortices. To gain traction on these issues, we have developed a battery of speech production tasks that is designed to mirror clinical electrical stimulation mapping and provides a within subject functional and causal comparison. We will use standard and high density electrocorticography (ECoG) to measure responses with high temporal precision within IFG. To determine causality, we will manipulate cortical activity using direct cortical stimulation and examine changes in behavior, timing of speech deficits and comparing with ECoG functional responses. The outcome of this study will greatly advance our understanding of the neurophysiologic mechanisms underlying speech production with a long-term goal of addressing a range of speech disorders and improving current language mapping techniques.

项目概要 言语是一种独特的人类特征，对我们的日常生活至关重要，但实现检索的机制 一些证据表明左下肢的发音序列的形成仍然难以捉摸。 额叶回 (IFG) 或布罗卡区在发音之前就处于活动状态，并且对发音起到重要支持作用 然而，目前尚不清楚 IFG 的不同解剖分区如何支持检索。 语义信息和发音规划。 为了调查这个问题，我们将利用纽约大学的资源，召集内部人士和研究人员 我们建议通过补充专业知识来重新审视 IFG 在演讲中的作用。 神经外科患者提供了一个难得且独特的机会来收集直接皮质记录和 具体来说，我们将解决以下问题：（1）什么是语音生成过程中的扰动。 IFG 中与言语产生相关的神经反应的时间常数，(2) 函数是什么 IFG 区域、岛盖部和三角部的特异性，以及 (3) 功能边界是什么 布罗卡区横跨左右额叶皮质。 为了获得对这些问题的关注，我们开发了一系列语音生成任务，旨在 镜像临床电刺激映射并提供受试者内部的功能和因果比较。 我们将使用标准和高密度皮层电图 (ECoG) 来测量高时间响应 为了确定因果关系，我们将使用直接皮层刺激来操纵皮层活动。 检查行为变化、言语缺陷发生时间并与 ECoG 功能反应进行比较。 这项研究的结果将极大地增进我们对神经生理机制的理解 潜在的言语产生，其长期目标是解决一系列言语障碍并改善 当前的语言映射技术。