Hemispheric asymmetry in auditory processing - spectral and temporal modulations

听觉处理中的半球不对称 - 频谱和时间调制

• 批准号: 8703518
• 负责人: Adeen Flinker
• 金额: $ 5.33万
• 依托单位: NEW YORK UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-01 至 2015-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8703518
• 关键词: Address; Animal Model; Animals; Auditory; Auditory area; Back; Bilateral; Clinical; Cognition; Comprehension; Diagnostic; Due Process; Electrocorticogram; Employee Strikes; Exhibits; Fourier Transform; Frequencies; Handedness; Human; Language; Language Disorders; Left; Lesion; Magnetoencephalography; Neurons; Population; Process; Recruitment Activity; Reporting; Research; Resolution; Right-On; Role; Speech; Speech Intelligibility; Stimulus; Techniques; Testing; Time; Uncertainty; Voice; auditory stimulus; computerized tools; language processing; neuromechanism; novel; receptive field; research study; response; speech processing; stimulus processing; tool

DESCRIPTION (provided by applicant): Language processing remains one of the most striking examples of hemispheric asymmetry. While much research has focused on elucidating the functional differences, the exact underlying mechanisms of the laterality remain unknown. Language function is severely disrupted in left but not right hemisphere lesions while damage to the right hemisphere impairs the processing of prosody. Many studies in both humans and animal models have exhibited similar functional asymmetries, nevertheless, the exact neuronal mechanisms underlying hemispheric lateralization in language remain unknown. Several hypotheses have been proposed explaining the functional asymmetries, including a differing hemispheric capacity for temporal and spectral resolution, a difference in the temporal scale of information integration as well as global vs. local processing of stimuli. The aim of this study is to propose and test a unifying hypothesis whereby the left hemisphere processes a wide range of temporal modulations and a limited range of spectral modulations and the right hemisphere processes a wide range of spectral modulations and a limited range of temporal modulations. Using novel stimuli filtering techniques, we propose altering speech stimuli on a spectral modulation and temporal modulation axis and directly test our hypothesis using Magnetoencephalography (MEG) and Electrocorticography (ECoG). Specifically, we will address: 1) Left and right hemisphere sensitivity to spectral and temporal modulations; 2) Task-related modulations of auditory cortex; 3) Spectrotemporal auditory receptive fields in higher order auditory cortical fields. !

描述（由申请人提供）：语言处理仍然是半球不对称的最引人注目的例子之一。尽管许多研究集中在阐明功能差异上，但横向性的确切潜在机制仍然未知。语言功能在左侧严重中断，但不是右半球病变，而对右半球的损害会损害韵律的处理。人类和动物模型的许多研究都表现出相似的功能不对称性，尽管如此，语言中半球横向化的确切神经元机制仍然未知。已经提出了一些假设，以解释功能性不对称，包括时间和光谱分辨率的不同半球能力，信息整合时间尺度的差异以及刺激的局部处理。这项研究的目的是 为了提出和检验统一的假设，左半球可以对广泛的时间调制和有限的光谱调制范围进行处理，并且右半球可以进行广泛的光谱调制和有限的时间调制范围。使用新型的刺激滤波技术，我们提出了在光谱调制和时间调制轴上改变语音刺激，并使用磁脑电图（MEG）和电皮质学（ECOG）直接检验我们的假设。具体而言，我们将解决：1）左右半球对光谱和时间调制的敏感性； 2）听觉皮层的任务相关调制； 3）较高听觉皮质场的光谱频率听觉接收场。呢