Extreme weather-related events and environmental exposures in the risk for Alzheimer's disease and related dementias

极端天气相关事件和环境暴露会增加阿尔茨海默病和相关痴呆症的风险

• 批准号: 10449041
• 负责人: Kathryn C Conlon
• 金额: $ 76.81万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-06-15 至 2027-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10449041
• 关键词: Address; Affect; African American population; Age; Aging; Air; Air Pollution; Alzheimer' s disease related dementia; Alzheimer' s disease risk; American; Amyloid; Birth; Brain; Caliber; California; Cardiovascular Diseases; Chemicals; Cognition; Cognitive; Cohort Studies; Computerized Medical Record; Data; Development; Droughts; Elderly; Environment; Environmental Exposure; Environmental Pollution; Environmental Risk Factor; Ethnic Origin; Ethnic group; Etiology; Event; Exposure to; Frequencies; Funding; Goals; Impaired cognition; Incidence; Individual; Intervention; Lead; Life; Life Experience; Link; Literature; Longevity; Magnetic Resonance Imaging; Malignant Neoplasms; Measures; Mercury; Methodology; Modernization; National Institute on Aging; Neurocognitive; Neuropsychological Tests; Neurotoxins; Older Population; Outcome; Outcome Study; Particulate; Particulate Matter; Pattern; Persons; Population; Population Heterogeneity; Positron-Emission Tomography; Precision Health; Prevention; Public Health; Race; Recommendation; Recording of previous events; Research; Risk; Risk Factors; Role; Sampling; Severities; Strategic Planning; Stroke; Temperature; Testing; Time; Ultrafine; United States National Institutes of Health; Wildfire; advanced disease; aging brain; behavior measurement; cardiovascular risk factor; climate change; clinical examination; cognitive function; cohort; dementia risk; disorder prevention; environmental chemical; extreme heat; extreme weather; fine particles; health data; healthy aging; imaging biomarker; improved; modifiable risk; multidimensional data; neuroimaging; neuroimaging marker; prevent; psychosocial; racial and ethnic; study population; symposium; trend; ultrafine particle

PROJECT SUMMARY The 2018 National Institute on Aging AD Research Summit recommendation of “Understanding the Impact of the Environment to Advance Disease Prevention” as a key strategic plan to treat and prevent Alzheimer's Disease and related dementias (ADRD) by 2025. Exposure to extreme weather-related events, air pollution, and environmental contaminants are pervasive, yet little is known about their relationships with ADRD, especially among a diverse older population. The proposed study addresses critical gaps in the literature by linking residential history on a diverse sample of over 3,379 individuals from 3 ongoing NIH-funded cohort studies (Kaiser Healthy Aging and Diverse Life Experiences (KHANDLE, n=1712, mean age 76.2, 71% non- White), the Study of Healthy Aging in African-Americans (STAR, n=764, mean age 68.4, 100% non-White) andLife After 90 (LA 90, n=903, mean age 92.7, 72% non-White)) to newly collected data on environmental exposures and will generate new granular, comprehensive, lifecourse measures of environmental exposures that will be used to examine their association with ADRD. All studies conduct harmonized neurocognitive assessments, clinical exams and neuroimaging, collect information on lifecourse risk factors, and are linked to health data (1960s-1990s) and electronic medical records (1996-present). Residential history at seven time points is collected (birth-current), and will be geocoded and linked to historic exposure data. The overall objective of this studyis to investigate exposure to extreme weather-related events, air pollution, and toxic environmental contaminants on cognitive function, ADRD, and neuroimaging biomarker in diverse aging populations. In a unique and unprecedented opportunity to comprehensively evaluate environmental exposures on late-life brainoutcomes, this study will address the following among 3,379 diverse Northern California residents: (1) Test the associations between exposure to extreme weather-related events (extreme heat, drought, wildfire) on neuroimaging markers, cognitive decline, and ADRD; (2) Determine the associations between exposure to ambient particulate air pollution (fine and ultrafine particulate matter (PM2.5, PM0.1)) on neuroimaging markers, cognitive decline, and ADRD; and (3) Assess the relationships between exposure to toxic environmental contaminants (lead, mercury) on neuroimaging markers, cognitive decline, and ADRD. Leveraging cumulative and time-dependent exposure to these environmental factors will illuminate lifecourse period in which exposureto these environmental factors is especially salient to healthy brain aging. Findings from this study have the potential to uncover new risk factors for ADRD and cognitive decline, and provide targets of ADRD interventionthat would improve healthy brain aging for people of all racial/ethnic groups.

项目摘要 2018年美国国家老化研究所研究峰会的建议 环境对预防疾病的影响”，作为治疗和治疗的关键战略计划 到2025年预防阿尔茨海默氏病和相关痴呆症（ADRD）。暴露于极端 与天气有关的事件，空气污染和环境污染物无处不在，但几乎没有 知道他们与ADRD的关系，尤其是在潜水员老年人中。这 拟议的研究通过将潜水员的历史联系起来来解决文献中的关键差距 来自3个正在进行的NIH资助的队列研究（Kaiser Healthy Emaging）的3,379多人的样本 和多样化的生活经历（Khandle，n = 1712，平均年龄76.2，71％非白人），研究 非裔美国人的健康衰老（Star，n = 764，平均年龄68.4，100％非白人）和生命之后 90（LA 90，n = 903，平均年龄92.7，72％非白人））到新收集的环境数据 暴露并将产生新的颗粒状，全面，生命的环境衡量标准 将用于检查其与ADRD的关联的暴露。所有研究进行 统一的神经认知评估，临床检查和神经影像学收集有关 生命力风险因素，并与健康数据（1960年代1990年代）和电子病历有关 （1996年）。收集了七个时间点的住宅历史（出生流），将是 地理编码并链接到历史暴露数据。这项研究的总体目的是调查 暴露于极端天气相关的事件，空气污染和有毒的环境污染物 潜水员老龄化人群中的认知功能，ADRD和神经影像标志物。独特 以及前所未有的机会，可以全面评估有关晚期的环境暴露 Brainoutcomes，这项研究将解决3,379名北加州潜水员 居民：（1）测试暴露于极端天气相关事件之间的关联（极端 热，干旱，野火）在神经影像学标记上，认知能力下降和ADRD； （2）确定 暴露于环境特定空气污染之间的关联 物质（PM2.5，PM0.1））关于神经影像标记，认知能力下降和ADRD； （3）评估 暴露于有毒环境污染物（铅，汞）之间的关系 神经影像学标记，认知能力下降和ADRD。利用累积和时间依赖性 暴露于这些环境因素将照亮生命周期，其中这些时期 环境因素对于健康的大脑衰老特别重要。这项研究的发现具有 潜力发现ADRD和认知能力下降的新危险因素，并提供ADRD的目标 干预将改善所有种族/族裔人群的健康脑老化。