The Interplay Between Negative Emotion Differentiation and Emotion Regulation Problems in Posttraumatic Stress Disorder

创伤后应激障碍中负面情绪分化与情绪调节问题之间的相互作用

基本信息

批准号：
10496561
负责人：
Cameron Pugach
金额：
$ 3.73万
依托单位：
UNIVERSITY OF NORTH CAROLINA GREENSBORO
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-01-01 至 2024-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10496561
关键词：
Active Learning Adult Affect American Behavioral Belief Biological Markers Brain region Cardiac Chronic Clinical Communities Cues Data Diagnosis Diagnostic Disease Drops Ecological momentary assessment Educational workshop Emotional Emotions Environment Etiology Exposure to Extinction Feeling Fright Funding Goals Grain Health Care Costs Heart Rate Impairment Individual Intervention Investigation Knowledge Label Laboratories Learning Life Link Maintenance Measurement Measures Mental disorders Mentorship Modeling Monitor National Institute of Mental Health National Research Service Awards Neurocognitive Deficit Outcome Parasympathetic Nervous System Patient Self-Report Pattern Periodicity Peripheral Persons Physiological Population Populations at Risk Post-Traumatic Stress Disorders Prevalence Process Psychophysiology Public Health Regulation Research Respiration Rest Risk Role Self Perception Services Severities Sinus Stimulus Symptoms System Testing Time Training Trauma Trauma recovery United States National Institutes of Health Variant biological adaptation to stress conditioned fear cost emotion regulation environmental adaptation experience falls flexibility functional disability improved indexing information processing insight member multilevel analysis negative affect negative emotional state physical conditioning post-traumatic stress prevent productivity loss psychiatric comorbidity psychologic respiratory response skills suicidal symptomatic improvement theories trait trauma exposure traumatic event

项目摘要

Project Summary/Abstract Posttraumatic stress disorder (PTSD) is characterized by inflexible patterns of experiential, behavioral, and physiological emotional responding. Following trauma exposure, the indiscriminate avoidance of trauma- related cues contributes to the maintenance of PTSD, which tends to be chronic and associated with a myriad of deleterious personal and public health consequences. Although inflexible emotional responding has been identified as a critical maintenance factor for PTSD, less is understood about how trauma-exposed people fall into these problematic emotion regulation patterns. Recent theory posits that the ability to differentiate between discrete negative emotions allows individuals to extract emotion-related information to guide the effective use of emotion regulation strategies in service of personal goals. When negative emotions are experienced with less granularity, emotion information becomes less readily available and places people at risk for maladaptive emotion regulation. Negative emotion differentiation (NED) has yet to be examined in the context of avoidance in PTSD, however, or in relation to markers of physiological inflexibility that are believed to contribute to emotion regulation problems across a range of clinical disorders, including PTSD. Thus, there is a need for an integrated investigation spanning multiple units of analysis to understand how NED confers risk for emotion regulation problems known to maintain PTSD. The objective of the proposed research is to elucidate whether NED is impaired in PTSD and associated with avoidance and resting respiratory sinus arrythmia (RSA) – a marker of physiological flexibility – in the lab and in daily life. Aims of the proposal include determining whether NED is impaired among those with PTSD relative to those without PTSD (Aim 1), whether NED is associated with self-reported trait avoidance and daily trauma-related avoidance (Aim 2), and whether NED is associated with resting RSA in the lab and in daily life (Aim 3). Given that NED is believed to guide emotion regulation strategy use based on the demands imposed by the environment, this project will also examine whether NED moderates the links between avoidance and PTSD (Aim 4). These aims will be tested using data from an ongoing NIH-funded study (1R15MH114142) of 80 trauma-exposed community members with and without PTSD. PTSD diagnosis and severity, trait-level avoidance, and resting RSA are assessed in the lab and three days of ecological momentary assessment and ambulatory physiological assessment are used to monitor daily trauma-related avoidance, resting RSA, and PTSD symptoms. The proposed project will advance the field by delineating associations between NED and emotion regulation problems across multiple units of analysis in PTSD. Elucidating the interplay between NED and emotion regulation problems may also provide insight into the etiology and maintenance of PTSD. As an NRSA F31 proposal, this project includes a training plan consisting of formal coursework, workshops, experiential learning, and mentorship in PTSD, emotion dynamics and regulation, autonomic psychophysiology, ambulatory assessment, and multilevel modeling.

项目摘要/摘要创伤后应激障碍（PTSD）的特征是经验，行为和身体情绪反应。暴露创伤后，不加区分的避免创伤相关提示有助于维持PTSD，这往往是慢性的，并且与无数有害的个人和公共卫生后果。尽管不灵活的情感反应一直是被确定为PTSD的关键维持因子，关于暴露于创伤的人如何跌倒的理解较少进入这些问题的情绪调节模式。最近的理论认为有区别的能力离散的负面情绪允许个人提取与情绪相关的信息以指导有效使用情绪调节策略为个人目标服务。当经历负面情绪时颗粒状较少，情绪信息变得越来越容易获得，使人们处于适应不良的风险情绪调节。负面情绪差异化（NED）尚未在回避的背景下进行检查但是包括PTSD在内的各种临床疾病中的情绪调节问题。那需要一个综合调查涵盖了多个分析单位，以了解NED如何承认情绪的风险已知维持PTSD的调节问题。拟议的研究的目的是阐明是否阐明 NED在PTSD中受到损害，与回避和静止呼吸窦A（RSA）有关身体灵活性的标记 - 在实验室和日常生活中。该提案的目的包括确定是否 NED相对于没有PTSD的人（AIM 1），NED是否受损，NED是否与避免自我报告的特征和每日与创伤有关的避免（AIM 2），以及NED是否与之相关在实验室和日常生活中休息RSA（AIM 3）。鉴于内德被认为可以指导情绪调节基于环境施加的要求的策略使用，该项目还将检查NED是否是否调节回避和PTSD之间的链接（AIM 4）。这些目标将使用来自 NIH资助的正在进行的研究（15MH114142）由80个受创伤的社区成员有或没有 PTSD。在实验室中评估了PTSD诊断和严重性，特质级避免和静止RSA，三个评估生态瞬时评估和门诊生理评估的天数用于监测每日与创伤有关的回避，静止的RSA和PTSD符号。拟议的项目将通过在多个分析单位中，NED与情绪调节问题之间的划定关联 PTSD。阐明NED和情绪调节问题之间的相互作用也可能会洞悉 PTSD的病因和维护。作为NRSA F31提案，该项目包括一个培训计划由PTSD中的正式课程，讲习班，专家学习和精神训练组成，情感动态和调节，自主心理生理学，门诊评估和多级建模。