Building a multi-scale vascular atlas of the mouse lower urinary tract

建立小鼠下尿路多尺度血管图谱

基本信息

批准号：
10355551
负责人：
JANET R KEAST
金额：
$ 31.98万
依托单位：
UNIVERSITY OF MELBOURNE
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-09-30 至 2026-07-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10355551
关键词：
3-Dimensional Address Adult Anatomy Atlases Axon Bladder Bladder Control Blood Vessels Clinical Clinical Medicine Communities Complex Computer Models Congestive Custom Data Data Collection Databases Development Diabetes Mellitus Dimensions Disease Embryo Environment Epithelial FAIR principles Female Fluid Balance Foundations Ganglia Generations Graph Growth Health Immunologic Surveillance Knowledge Lectin Life Cycle Stages Light Literature Lower urinary tract Lymphatic Maps Methodology Methods Microscopy Mus Muscle Nerve Nerve Plexus Organ Outcome Output Pattern Pelvis Perfusion Pregnancy Regulation Research Resolution Resources Rodent Sampling Sensory Source Stretching Structure Syndrome System Thick Three-Dimensional Image Time Tissue Engineering Tissues Urethra Validation Vascular System Venous Venous system Viral Visualization Weaning base design human data immature animal knowledge base male nerve supply neurovascular novel strategies prepuberty pressure relating to nervous system tool urinary bladder neck

项目摘要

ABSTRACT This GUDMAP Atlas project is focused on the lower urinary tract (LUT; bladder and urethra) of male and female mice. The Specific Aims are to build 3D multiscale anatomical atlases of (1) the mouse LUT vasculature and (2) the autonomic and sensory innervation of this vasculature. Times of the life cycle from embryo to adult have been selected to reveal the impact of major changes in organ structure and function on vascular patterning. The outcomes of Aim 1 will fill a major gap in GUDMAP and the broader literature, where LUT vascular structures have been under-explored in comparison with LUT muscle wall and epithelium. The outcomes of Aim 2 will provide a second important dimension to GUDMAP and the literature, by superimposing on the vascular atlases the closely associated axonal plexuses (sensory and autonomic) that regulate LUT vascular function. Most of these axon classes do not originate from pelvic ganglia, so provide to the GUDMAP database new resources that are quite distinct from the existing knowledge base. In addition to developing new knowledge on the vascular system, the outcomes of the project will support generation of new hypotheses on LUT function in health and disease. .

抽象的该 GUDMAP Atlas 项目重点关注男性和女性的下尿路（LUT；膀胱和尿道）雌性小鼠。具体目标是构建 (1) 小鼠 LUT 的 3D 多尺度解剖图谱脉管系统和（2）该脉管系统的自主神经和感觉神经支配。生命周期的次数从选择胚胎到成人来揭示器官结构和功能重大变化的影响关于血管模式。目标 1 的成果将填补 GUDMAP 和更广泛文献中的主要空白，与 LUT 肌肉壁相比，LUT 血管结构尚未得到充分探索上皮。目标 2 的成果将为 GUDMAP 和文献中，通过将密切相关的轴突丛（感觉和神经丛）叠加在血管图谱上自主神经）调节 LUT 血管功能。大多数这些轴突类并非起源于骨盆 ganglia，因此向 GUDMAP 数据库提供与现有资源截然不同的新资源知识库。除了开发有关血管系统的新知识外，该研究的成果该项目将支持 LUT 在健康和疾病中的功能的新假设的产生。。