Biobehavioral Measurements of Alertness in Sleep Apnea

睡眠呼吸暂停警觉性的生物行为测量

• 批准号: 6748529
• 负责人: Daniel J Levendowski
• 金额: $ 28.53万
• 依托单位: ADVANCED BRAIN MONITORING, INC.
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-05-07 至 2005-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6748529
• 关键词: attention; biomedical equipment development; computer assisted diagnosis; electroencephalography; human data; information systems; memory; neuropsychological tests; neuropsychology; patient monitoring device; performance; polysomnography; psychomotor function; sleep apnea; wakefulness

DESCRIPTION (Applicant's abstract): The proposed research evaluates the efficacy of the Alertness Profiling (AP) System as a method for objectively quantifying alertness in Sleep Apnea (SA) patients. The AP simultaneously measures electroencephalographic (EEG) indices and performance during vigilance, attention and memory tests. Combining EED and neurobehavioral assessment in a one-hour session, the AP evaluates level of alertness and its effects on accuracy, reaction time and memory. The AP system integrates and easy to-apply EEG headset, PC-based performance tests and a normative database to provide diagnostic assessment and treatment outcome evaluation of SA. In Phase I, hardware and software refinements will be implemented to improve ease of-application, standardize administration, and minimize technician intervention. Pilot data, previously collected from 57 SA patients will be further analyzed to clarify interpretation of results and to develop and apply consensus SA diagnostic criteria. The AP is a convenient, cost-effective method for clinicians, employers, and researchers to measure daytime drowsiness and simultaneously quantify effects on neurobehavioral performance. With physicians increasingly responsible for evaluating vigilance (e.g. commercial drivers) new methods are required for routine assessment. The AP will provide physicians and epidemiological researchers and accurate determination of impact of SA on daytime alertness and performance. PROPOSED COMMERCIAL APPLICATION: NOT AVAILABLE

描述（申请人的摘要）：拟议的研究评估了 警觉性分析（AP）系统作为客观方法的有效性 量化睡眠呼吸暂停 (SA) 患者的警觉性。 AP 同时 测量脑电图 (EEG) 指数和表现 警惕性、注意力和记忆力测试。结合 EED 和神经行为 在一小时的评估中，AP 评估警觉性水平及其 对准确性、反应时间和记忆力的影响。 AP系统集成了 易于应用的脑电图耳机、基于 PC 的性能测试和标准化数据库 提供SA的诊断评估和治疗结果评估。在 第一阶段，将实施硬件和软件改进以提高易用性 应用程序化、标准化管理、最大限度减少技术人员 干涉。先前从 57 名 SA 患者收集的试点数据将被 进一步分析以澄清结果的解释并开发和应用 共识 SA 诊断标准。 对于临床医生、雇主和医疗机构来说，AP 是一种方便且经济高效的方法。 研究人员测量白天的睡意并同时量化影响 关于神经行为表现。随着医生的责任越来越大 评估警惕性（例如商业司机）需要新方法 常规评估。美联社将提供医生和流行病学 研究人员准确确定 SA 对白天警觉性的影响 表现。 拟议的商业应用：不可用

项目成果

EEG correlates of task engagement and mental workload in vigilance, learning, and memory tasks.

脑电图将警觉性、学习和记忆任务中的任务投入度和脑力负荷相关联。

• 发表时间: 2007-05
• 作者: Berka, Chris;Levendowski, Daniel J;Lumicao, Michelle N;Yau, Alan;Davis, Gene;Zivkovic, Vladimir T;Olmstead, Richard E;Tremoulet, Patrice D;Craven, Patrick L
• 通讯作者: Craven, Patrick L