A Biological Assessment System for Cognitive Persistence

认知持久性的生物评估系统

• 批准号: 7108002
• 负责人: Christopher Hyde
• 金额: $ 24.99万
• 依托单位: BIOASSESSMENTS, LLC
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-06-03 至 2008-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7108002
• 关键词: adolescence (12-20); angiotensin II; attention; attention deficit disorder; behavioral /social science research tag; biomedical equipment development; blood tests; brain circulation; central nervous system stimulants; cerebrovascular imaging /visualization; clinical research; cognition; computer assisted diagnosis; developmental psychology; diagnosis design /evaluation; electrocardiography; heart rhythm; human subject; impulsive behavior; interactive multimedia; mental disorder chemotherapy; mental disorder diagnosis; middle childhood (6-11); psychophysiology; ultrasound blood flow measurement; young adult human (21-34)

DESCRIPTION (provided by applicant): The low frequency cardiac rhythm (LFCR) is a promising biological marker for psychological research. The primary goal of this project is to make the LFCR methodology more accessible to researchers by providing a both a product and extensive support services. In Phase I, a prototype system was built and used to collect simultaneous physiological and cognitive data from 41 elementary school children. The LFCR consistently decreased when children attended to computerized tasks (i.e., under conditions requiring cognitive persistence). In a preliminary pilot study, children with ADHD did not have the same decrease in the LFCR when they attempted to pay attention on the same tasks; however, they did have decreased LFCR after taking their psycho stimulant medication. A secondary goal of this project is to more firmly establish the biological underpinnings of the LFCR. Prior to the Phase I work, angiotensin activity was hypothesized to mediate the relationship between LFCR, cerebral blood flow and cognitive activity. This hypothesis was partially confirmed with the empirical evidence collected in Phase I. Blood assays validated the connection between LFCR and circulating levels of angiotensin. Transcranial Doppler sonography (TCD) data validated that connection between cerebral blood flow and LFCR. These results provide strong empirical support for the proposed biological model of cognitive persistence. This work will be expanded in Phase II through three main tasks. 1) The prototype will be further refined into a user-friendly commercial product. 2) The database of physiological changes in children and adults during cognitive performance will be enlarged using LFCR, TCD, and blood assays (adults only); ADHD participants will be tested before and after taking medication. 3) Strategic collaborations with researchers will be formed to demonstrate the value of the biological measure in other areas of research. Two impediments currently limit the use of LFCR in research studies. First, the biological basis of LFCR was inadequately characterized. The Phase I and II findings will address this limitation. Second, the methodology is too complex for most researchers without expertise in this area. BioAssessments will overcome this impediment by providing both turnkey equipment and extensive support throughout all stages of the research project. The feasibility of this business model will be demonstrated by Phase II collaborations and publications that serve as case studies. The anticipated Phase III customer will be a researcher studying impulsivity in disorders such as Attention Deficit/Hyperactivity Disorder (ADHD) and substance abuse.

描述（由申请人提供）：低频心律（LFCR）是心理学研究中很有前途的生物标志物。该项目的主要目标是通过提供产品和广泛的支持服务，使研究人员更容易使用 LFCR 方法。在第一阶段，建立了一个原型系统，用于收集 41 名小学生的同步生理和认知数据。当儿童参与计算机化任务时（即在需要认知持久性的条件下），LFCR 持续下降。在一项初步的试点研究中，患有多动症的儿童在试图集中注意力于相同的任务时，LFCR 并没有出现同样的下降。然而，在服用精神兴奋药物后，他们的 LFCR 确实有所下降。该项目的第二个目标是更牢固地建立 LFCR 的生物学基础。在第一阶段工作之前，假设血管紧张素活性介导 LFCR、脑血流量和认知活动之间的关系。这一假设得到了第一阶段收集的经验证据的部分证实。血液检测验证了 LFCR 与血管紧张素循环水平之间的联系。经颅多普勒超声检查 (TCD) 数据验证了脑血流与 LFCR 之间的联系。这些结果为所提出的认知持久性生物学模型提供了强有力的实证支持。这项工作将在第二阶段通过三项主要任务得到扩展。 1）原型将进一步完善为用户友好的商业产品。 2) 将使用 LFCR、TCD 和血液检测（仅限成人）扩大儿童和成人认知表现期间生理变化的数据库；多动症参与者将在服药前和服药后接受测试。 3) 将与研究人员建立战略合作，以证明生物测量在其他研究领域的价值。目前有两个障碍限制了 LFCR 在研究中的使用。首先，LFCR 的生物学基础没有得到充分表征。第一阶段和第二阶段的研究结果将解决这一限制。其次，对于大多数没有该领域专业知识的研究人员来说，该方法过于复杂。 BioAssessments 将通过在研究项目的各个阶段提供交钥匙设备和广泛的支持来克服这一障碍。该商业模式的可行性将通过第二阶段的合作和作为案例研究的出版物来证明。预期的 III 期客户将是一名研究注意力缺陷/多动症 (ADHD) 和药物滥用等疾病冲动的研究人员。