A Biological Assessment System for Cognitive Persistence

认知持久性的生物评估系统

• 批准号: 6646870
• 负责人: Christopher Hyde
• 金额: $ 10万
• 依托单位: BIOASSESSMENTS, LLC
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-06-03 至 2004-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6646870
• 关键词: angiotensins; attention deficit disorder; biomarker; clinical research; cognition; diagnosis design /evaluation; electrocardiography; heart rate; human subject; mental disorder diagnosis; psychometrics; psychophysiology; ultrasonography

DESCRIPTION (provided by applicant): The low frequency cardiac rhythm (LFCR) is an innovative, but underutilized, biological marker. The PI's studies show that LFCR is strongly associated with the state of cognitive persistence in controls. Cognitive persistence refers to the ability to remain on-task and inhibit impulsive off-task behavior. Additional preliminary data also suggest that children with Attention Deficit Hyperactivity Disorder (ADHD) may have differences in LFCR during cognitive tasks. A testable biological model of angiotensin activity is proposed to explain the empirically observed correlation between LFCR and cognitive functioning. Three impediments prevent the more extensive inclusion of LFCR in research studies. First, the methodology is too complex and time-consuming for most researchers. Second, the biological basis of LFCR is inadequately understood. Third, the psychometric properties of LFCR have not been fully characterized. BioAssessments will develop a turnkey biological/assessment system that integrates biological monitoring and cognitive assessment to solve these three impediments. The goals of Phase I are to remove these three impediments to using LFCR in research. To address the first impediment, a prototype will be built that permits nonspecialists to readily monitor LFCR. To address the second impediment, two additional biological measures will be used to confirm the biological basis of LFCR: blood assays of angiotensin and Transcranial Doppler sonography (TCD). To address the third impediment, 40 elementary school children will be simultaneously monitored (LFCR, blood assays, TCD) while performing two cognitive tasks. These data will be used to characterize the psychometric properties of LFCR. The PI has demonstrated the feasibility of this concept in three prior projects with children and adults. The Phase I product will make LFCR measurements more accessible to researchers and better grounded in a biological mechanism. In Phase II, the clinical utility of the proposed product will be validated at several additional research sites. The proposed product has the potential to address a pressing clinical need for better ADHD assessment tools. In Phase III, the turnkey system would be marketed to researchers who do not have specialized psychophysiological expertise. Long-term commercial applications may include the clinical assessment of ADHD.

描述（由申请人提供）：低频心律（LFCR）是一种创新但未充分利用的生物标志物。 PI 的研究表明，LFCR 与对照组的认知持续状态密切相关。认知持久性是指保持专注于任务并抑制冲动的非任务行为的能力。其他初步数据还表明，患有注意力缺陷多动障碍 (ADHD) 的儿童在认知任务期间 LFCR 可能存在差异。提出了一种可测试的血管紧张素活性生物学模型来解释凭经验观察到的 LFCR 与认知功能之间的相关性。三个障碍阻碍了 LFCR 更广泛地纳入研究。首先，对于大多数研究人员来说，该方法过于复杂且耗时。其次，对 LFCR 的生物学基础了解不够。第三，LFCR 的心理测量特性尚未得到充分表征。 BioAssessments 将开发一个交钥匙生物/评估系统，集成生物监测和认知评估，以解决这三个障碍。第一阶段的目标是消除在研究中使用 LFCR 的这三个障碍。为了解决第一个障碍，将构建一个原型，允许非专业人士轻松监控 LFCR。为了解决第二个障碍，将使用另外两种生物学措施来确认 LFCR 的生物学基础：血管紧张素的血液检测和经颅多普勒超声检查 (TCD)。为了解决第三个障碍，将在执行两项认知任务的同时对 40 名小学生进行同时监测（LFCR、血液检测、TCD）。这些数据将用于表征 LFCR 的心理测量特性。 PI 在之前的三个儿童和成人项目中证明了这一概念的可行性。第一阶段产品将使研究人员更容易进行 LFCR 测量，并更好地立足于生物机制。在第二阶段，拟议产品的临床效用将在几个额外的研究地点得到验证。拟议的产品有可能满足临床对更好的多动症评估工具的迫切需求。在第三阶段，交钥匙系统将向不具备专门心理生理学专业知识的研究人员推销。长期商业应用可能包括 ADHD 的临床评估。