Development of a Wearable Near-Infrared Blood Alcohol Content Monitor

可穿戴式近红外血液酒精含量监测仪的研制

• 批准号: 9608961
• 负责人: Ryan Timothy Myers
• 金额: $ 23.57万
• 依托单位: VIVONICS, INC.
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-01 至 2020-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9608961
• 关键词: Acute; Alcohol consumption; Alcoholic Beverages; Alcohols; Algorithms; American; Automobiles; Blood; Blood alcohol level measurement; Blood flow; Breath Tests; Calibration; Characteristics; Clinical; Clinical Research; Clothing; Communities; Custom; Data; Data Set; Dermal; Development; Devices; Dose; Esthetics; Ethanol; Foundations; Frequencies; General Population; Geography; Goals; Gold; Health; Heart Rate; Hydration status; Individual; Intoxication; Intracranial Pressure; Laboratories; Legal; Light; Medical; Melanins; Methods; Modeling; Monitor; Near-Infrared Spectroscopy; Optics; Organization administrative structures; Output; Persons; Phase; Physiologic Monitoring; Physiological; Physiology; Police; Police officer; Property; Questionnaires; Recording of previous events; Records; Reporting; Research; Scanning; Site; Spectrum Analysis; Stigmatization; Sweat; System; Techniques; Testing; Tissue Viability; Tissues; Translating; United States; User Compliance; Variant; Water; absorption; addiction; alcohol effect; alcohol response; base; density; dosage; help-seeking behavior; human subject; improved; interest; miniaturize; monitoring device; novel; personalized approach; programs; prototype; social stigma; tool; wearable device

Project Summary/Abstract The United States alcoholic beverage market topped $210 Billion in 2014, selling enough alcohol for each American to consume 9.2 liters (2.4 gallons) of pure alcohol in 2013. Due to alcohol consumption's long history and ample financial interest, there has been a great deal of research around alcohol and the benefits and detriments to consuming it. Despite the commonality of alcohol consumption and the ability for users to abuse the intoxicant, there remains a stigma around monitoring blood alcohol content (BAC) in a public forum (e.g. breathalyzers by police officers and breathalyzer controlled automobile ignitions). This stigma generally holds true even when part of a clinical study or while seeking help for an addiction. Thus, there is still a need for a BAC monitoring device that remains out of site or can be camouflaged into everyday items (e.g. clothing, jewelry, accessories), which has yet to be met be current systems. Near-infrared spectroscopy (NIRS) has been used by Vivonics to monitor and report a number of physiologically relevant parameters. Studies have shown the ability to use near-infrared wavelengths to estimate the blood alcohol concentration with a low error of 0.0049% BAC (legally intoxicated BAC is 0.08). The proposed effort will apply this approach but tailor implementation in a way that enables a miniaturized, wearable device which is accurate despite variations in physiology. Utilizing this concept, the goal of the proposed Phase I effort is to develop an accurate and temporally resolute BAC monitoring benchtop prototype. The overall goal of the Phase I effort is to demonstrate feasibility of the miniaturized NIRS approach, paving the way for human subject testing in Phase II. The long term goal of this program is to deliver an accurate and temporally resolute wearable BAC monitoring device that substantially improves subject compliance in clinical and academic research. The proposed program would not only benefit the research community, providing a tool to better understand how alcohol dose and frequency impacts physiological and physiological health, but would also benefit the general public on a larger scale by translating the findings from the research community into more responsible and healthy alcohol consumption practices.

项目概要/摘要 2014 年美国酒精饮料市场突破 2100 亿美元，每人销售足够的酒精 2013年美国人将消费9.2升（2.4加仑）纯酒精。由于酒精消费历史悠久 和充足的经济利益，围绕酒精及其好处和作用进行了大量研究 对其食用有不利影响。尽管饮酒具有普遍性并且使用者有滥用酒精的能力 作为一种麻醉品，在公共论坛（例如， 警察的呼气分析仪和控制汽车点火装置的呼气分析仪）。这种耻辱普遍存在 即使是在临床研究的一部分或在寻求成瘾帮助时也是如此。因此，仍然需要一个 BAC 监测装置可以留在现场或可以伪装成日常物品（例如衣服、 珠宝、配饰），这是当前系统尚未满足的。近红外光谱（NIRS）已被 Vivonics 使用它来监测和报告许多生理相关参数。研究表明 能够使用近红外波长以较低的误差估计血液酒精浓度 0.0049% BAC（合法中毒的 BAC 为 0.08）。拟议的工作将应用这种方法，但会进行定制 以一种能够实现小型化、可穿戴设备的方式实现，尽管存在变化，但该设备仍然准确 生理。利用这一概念，拟议的第一阶段工作的目标是开发一个准确且 暂时稳定的 BAC 监测台式原型。第一阶段工作的总体目标是证明 小型化 NIRS 方法的可行性，为第二阶段的人体测试铺平了道路。长的 该计划的长期目标是提供准确且临时稳定的可穿戴 BAC 监测设备 这大大提高了临床和学术研究中的受试者依从性。拟议的计划将 不仅有利于研究界，还提供了一个工具来更好地了解饮酒剂量和频率 影响生理和生理健康，但也将在更大范围内造福广大公众 将研究界的发现转化为更负责任和健康的饮酒方式 做法。