Development of a Wearable Near-Infrared Blood Alcohol Content Monitor

可穿戴式近红外血液酒精含量监测仪的研制

• 批准号: 9608961
• 负责人: Ryan Timothy Myers
• 金额: $ 23.57万
• 依托单位: VIVONICS, INC.
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-01 至 2020-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9608961
• 关键词: Acute; Alcohol consumption; Alcoholic Beverages; Alcohols; Algorithms; American; Automobiles; Blood; Blood alcohol level measurement; Blood flow; Breath Tests; Calibration; Characteristics; Clinical; Clinical Research; Clothing; Communities; Custom; Data; Data Set; Dermal; Development; Devices; Dose; Esthetics; Ethanol; Foundations; Frequencies; General Population; Geography; Goals; Gold; Health; Heart Rate; Hydration status; Individual; Intoxication; Intracranial Pressure; Laboratories; Legal; Light; Medical; Melanins; Methods; Modeling; Monitor; Near-Infrared Spectroscopy; Optics; Organization administrative structures; Output; Persons; Phase; Physiologic Monitoring; Physiological; Physiology; Police; Police officer; Property; Questionnaires; Recording of previous events; Records; Reporting; Research; Scanning; Site; Spectrum Analysis; Stigmatization; Sweat; System; Techniques; Testing; Tissue Viability; Tissues; Translating; United States; User Compliance; Variant; Water; absorption; addiction; alcohol effect; alcohol response; base; density; dosage; help-seeking behavior; human subject; improved; interest; miniaturize; monitoring device; novel; personalized approach; programs; prototype; social stigma; tool; wearable device

Project Summary/Abstract The United States alcoholic beverage market topped $210 Billion in 2014, selling enough alcohol for each American to consume 9.2 liters (2.4 gallons) of pure alcohol in 2013. Due to alcohol consumption's long history and ample financial interest, there has been a great deal of research around alcohol and the benefits and detriments to consuming it. Despite the commonality of alcohol consumption and the ability for users to abuse the intoxicant, there remains a stigma around monitoring blood alcohol content (BAC) in a public forum (e.g. breathalyzers by police officers and breathalyzer controlled automobile ignitions). This stigma generally holds true even when part of a clinical study or while seeking help for an addiction. Thus, there is still a need for a BAC monitoring device that remains out of site or can be camouflaged into everyday items (e.g. clothing, jewelry, accessories), which has yet to be met be current systems. Near-infrared spectroscopy (NIRS) has been used by Vivonics to monitor and report a number of physiologically relevant parameters. Studies have shown the ability to use near-infrared wavelengths to estimate the blood alcohol concentration with a low error of 0.0049% BAC (legally intoxicated BAC is 0.08). The proposed effort will apply this approach but tailor implementation in a way that enables a miniaturized, wearable device which is accurate despite variations in physiology. Utilizing this concept, the goal of the proposed Phase I effort is to develop an accurate and temporally resolute BAC monitoring benchtop prototype. The overall goal of the Phase I effort is to demonstrate feasibility of the miniaturized NIRS approach, paving the way for human subject testing in Phase II. The long term goal of this program is to deliver an accurate and temporally resolute wearable BAC monitoring device that substantially improves subject compliance in clinical and academic research. The proposed program would not only benefit the research community, providing a tool to better understand how alcohol dose and frequency impacts physiological and physiological health, but would also benefit the general public on a larger scale by translating the findings from the research community into more responsible and healthy alcohol consumption practices.

项目摘要/摘要 美国酒精饮料市场在2014年超过2100亿美元 美国在2013年消费9.2升（2.4加仑）的纯酒精。由于酒精消费的悠久历史 而且充足的财务利益，关于酒精和利益的研究很多 消耗它的损害。尽管饮酒的共同点和用户滥用的能力 在公共论坛中监测血液酒精含量（BAC）的污名（例如， 警察和呼吸仪控制的汽车点火器的呼吸器。这个污名通常持有 即使是临床研究的一部分或寻求成瘾的帮助时，也是如此。因此，仍然需要 剩下现场或可以伪装成日常物品的BAC监视设备（例如服装， 珠宝，配件），尚未达到当前系统。近红外光谱（NIRS）已经 Vivonics用于监测和报告许多与生理相关的参数。研究表明 使用近红外波长以低误差为 0.0049％BAC（合法陶醉的BAC为0.08）。拟议的努力将采用这种方法，但量身定制 实施的方式可以实现微型，可穿戴设备，尽管有所不同 生理。利用这个概念，提议的I期努力的目标是开发准确的和 暂时性地凝结BAC监测台式原型。第一阶段努力的总体目标是证明 小型NIRS方法的可行性，为II阶段的人类受试者测试铺平了道路。长 该程序的术语目标是提供准确且具有暂时性的可穿戴BAC监控设备 这大大提高了临床和学术研究中的主题依从性。拟议的计划将 不仅使研究社区受益，提供了一种工具来更好地了解酒精剂量和频率 影响生理和生理健康，但也将通过 将研究界的发现转化为更负责和健康的饮酒量 实践。