Cellular and Molecular Imaging Core

细胞和分子成像核心

基本信息

批准号：
10311497
负责人：
REBECCA LUCY HULL-MEICHLE
金额：
$ 10.57万
依托单位：
UNIVERSITY OF WASHINGTON
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-02-10 至 2022-11-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10311497
关键词：
Achievement Applications Grants Area Collaborations Comparative Pathology Computer software Core Facility Data Diabetes Mellitus Disease Ensure Equipment Fluorescence Fostering Funding Goals Histocytochemistry Human Resources Image Image Analysis Imaging Techniques Immunohistochemistry Individual Institution Investigation Knowledge Leadership Manuscripts Methodology Methods Microscopy Microtomy Morphology Obesity Pathologist Peer Review Grants Process Productivity Protocols documentation Publishing Quality Control Quantitative Microscopy Reagent Reproducibility Research Research Design Research Personnel Scanning Services Techniques Tissue imaging Tissues Training Universities Washington Work base body system cellular imaging comparative cost effective diabetes pathogenesis experimental study flexibility high standard imaging modality innovation instrumentation laser capture microdissection microscopic imaging molecular imaging preclinical study response tissue processing

项目摘要

The Cellular and Molecular Imaging Core, which had its origin in 1977, facilitates the outstanding and innovative research of Diabetes Research Center affiliates in the Seattle area by keeping pace with and pioneering new methodological and technical advances in histochemistry, microscopic imaging and image analysis. In the next funding cycle the CMIC will continue to promote the research of these investigators during the next funding cycle by providing: (1) Quantitative assessment of immunohistochemistry and morphological changes in tissues; (2) Access to state-of-the-art imaging instrumentation, in a cost-effective manner; (3) Expert diabetes-related technical and scientific support, including design of research protocols and interpretation of results; (4) Access to comparative pathologists, to assist with experimental and/or preclinical studies; and (5) Hands-on and didactic training to affiliates, their trainees and personnel with routine and highly specialized morphological, histochemical and imaging techniques. Through all of these services, the Cellular and Molecular Imaging Core places a great deal of emphasis on ensuring high standards of rigor and reproducibility for studies undertaken in the Core. This includes, but is not limited to, rigorous quality control for reagents, expert review of protocols and ensuring appropriate and adequate use of positive and negative controls. By achieving these goals, the Cellular and Molecular Imaging Core will support the scientific investigation of affiliate investigators who will use the core to further our understanding of diabetes, obesity and related disorders.

其起源于1977年的细胞和分子成像核心促进了杰出的和西雅图地区糖尿病研究中心分支机构的创新研究通过跟上和开创组织化学，微观成像和图像的新方法和技术进步分析。在下一个资金周期中，CMIC将继续促进这些研究者的研究下一个通过提供的资金周期：（1）免疫组织化学和形态学的定量评估组织的变化；（2）以具有成本效益的方式访问最先进的成像仪器；（3）专家糖尿病相关的技术和科学支持，包括研究方案的设计结果解释；（4）访问比较病理学家，以协助实验和/或临床前研究；（5）对分支机构的实践和教学培训，他们的学员和人员都有常规和高度专门的形态学，组织化学和成像技术。通过所有这些服务，蜂窝和分子成像核心核心非常重视确保高标准的严格标准和在核心进行的研究的可重复性。这包括但不限于严格的质量控制试剂，协议的专家审查以及确保适当且充分利用正面和负面控件。通过实现这些目标，细胞和分子成像核心将支持科学调查会员调查员，他们将利用核心来进一步了解糖尿病，肥胖和相关疾病。