FHS-NEXT - Framingham Novel EXam using Technology

FHS-NEXT - 使用技术的弗雷明汉小说考试

• 批准号: 10311514
• 负责人: Emelia J. Benjamin
• 金额: $ 61.58万
• 依托单位: BOSTON UNIVERSITY MEDICAL CAMPUS
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-12-15 至 2024-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10311514
• 关键词: Address; Adherence; Affect; Age; Apple; Behavior; Behavioral Sciences; Big Data; Blood Pressure; Blood Vessels; Cardiopulmonary; Cardiovascular Diseases; Cardiovascular system; Charge; Clinic; Clinical; Clinical Research; Cohort Studies; Communication; Communities; Custom; Data; Data Collection; Development; Devices; Disease; Disease Surveillance; Documentation; Epidemiology; Event; Evolution; Exercise; Exercise Test; Failure; Framingham Heart Study; Funding; Generations; Goals; Gold; Grant; Health; Health Technology; Health behavior; Heart Rate; Home; Home Blood Pressure Monitoring; Hypertension; Individual; Informatics; Interdisciplinary Study; Knowledge; Life Style; Measures; Medical; Methods; Modeling; Monitor; Nature; Oxygen; Participant; Persons; Phenotype; Physiologic pulse; Publishing; Recovery; Reporting; Research; Research Methodology; Resources; Rest; Risk Factors; Secure; Seminal; Surveys; System; Technology; Testing; Time; Training; United States National Institutes of Health; Work; World Health; arterial stiffness; arterial tonometry; base; blood pressure variability; cardiovascular disorder epidemiology; cardiovascular disorder risk; cardiovascular fitness; cardiovascular health; clinical epidemiology; clinical practice; cohort; data integration; database of Genotypes and Phenotypes; design; digital; digital health; disease phenotype; epidemiology study; exercise capacity; fitness; handheld mobile device; health data; improved; innovation; insight; mHealth; multi-ethnic; multidisciplinary; novel; prototype; sensor; sex; smart watch; smartphone Application; standard measure; tonometry; uptake; usability; user-friendly

Abstract Traditional epidemiology cohorts have contributed greatly to our understanding of CVD and its risk factors, but concerns have been raised about their resource intensive nature, as well as their failure to integrate data from outside the research center. Digital and mobile health (mHealth) technologies provide data on individuals’ behaviors, risk factors, and CVD events. The growing ubiquity of mHealth solutions provides an unprecedented opportunity to add novel “real world” cardiovascular phenotypes to cohort studies. MHealth may facilitate more frequent, convenient, and meaningful interactions with cohort participants. Despite the availability of myriad devices, few systems have been designed to facilitate long-term cardiovascular phenotyping and CVD surveillance. We propose to enhance the FHS-NExT (Framingham Heart Study-Novel Examination using Technology) system, which includes a custom smartphone application (app) and data from a smartwatch (heart rate/steps) and digital blood pressure (BP) cuff, for use by FHS Generation 3 (Gen3) and multi-ethnic Omni 2 participants. We will identify factors associated with long-term adherence, and relations between mHealth and digital phenotypes with validated measures of fitness and arterial stiffness. Specific aims: Aim 1. Enhance the FHS-NExT smartphone app to promote adherence and compare the new FHS-NExT app CVD risk factor surveys against conventional measures in the FHS Research Center. We will enhance the FHS-NExT app, add new messaging and interactive capabilities to facilitate long-term use of the FHS-NExT app (n=2250), smartwatch (n=1500), and BP device (n=1500) and correlate FHS CVD risk score as assessed using the app to the FHS CVD risk score from the research center exam. Aim 2. Identify factors associated with successful long-term use of the FHS-NExT system, including the app, smartwatch, and digital BP device. System adherence will be defined based on: 1) app completion of lifestyle and CVD risk factor surveys every 3 months (n=2250); 2) donning the smartwatch and recording ≥1000 steps daily (n=1500); and 3) taking BP measures ≥once weekly (n=1500). We will identify participant or system-related factors, that affect adherence to the FHS-NExT system (n=1500 participants) over 12 months. Aim 3. Examine relations of novel exercise capacity measures by cardiopulmonary exercise testing (CPET) with average resting HR and daily step counts from smartwatch recordings over 30 days. Aim 4. Examine relations of arterial stiffness by tonometry with mean weekly BP and mean BP variability over 6 months. We bring together a highly productive, multi-disciplinary team with expertise in app development, mHealth and digital research methods and analysis, “big data” integration, behavioral science, & CVD epidemiology. We propose to build new, scalable capabilities for digital and mHealth data collection, and test the relations between traditional in-clinic measures of cardiovascular fitness and arterial tonometry and novel mHealth phenotypes.

抽象的 传统的流行病学队列为我们对CVD及其危险因素的理解做出了巨大贡献，但 人们对其资源密集型性质以及他们未能整合来自的数据引起了人们的关注 在研究中心外。数字和移动健康（MHealth）技术提供了有关个人的数据 行为，风险因素和CVD事件。 MHealth Solutions的无处不在，提供了前所未有的 将新颖的“现实世界”心血管表型添加到队列研究中的机会。 MHealth可能会促进更多 经常与队列参与者进行方便且有意义的互动。尽管有无数 设备，几乎没有设计用于促进长期心血管表型和CVD的系统 监视。我们建议增强FHS-next（使用 技术）系统，其中包括自定义智能手机应用程序（APP）和智能手表的数据 （心率/步骤）和数字血压（BP）袖口，用于FHS 3（GEN3）和多种族使用 OMNI 2参与者。我们将确定与长期依从性相关的因素以及 MHealth和数字表型具有验证的健身和动脉刚度。具体目的： AIM 1。增强FHS-NEXT智能手机应用程序以促进依从性并比较新的FHS-Next APP CVD风险因素对FHS研究中心的常规措施进行调查。我们将 增强FHS-Next应用程序，添加新的消息传递和交互式功能，以促进长期使用 FHS-Next应用程序（n = 2250），智能手表（n = 1500）和BP设备（n = 1500），并将FHS CVD风险分数与 通过研究中心考试的FHS CVD风险评分进行评估。 目标2。确定与FHS-next系统成功使用的因素，包括 应用，智能手表和数字BP设备。系统依从性将根据以下方式定义：1）应用程序完成 每3个月的生活方式和CVD风险因素进行一次调查（n = 2250）； 2）戴上智能手表和录制 每天≥1000步（n = 1500）； 3）每周进行BP测量≥（n = 1500）。我们将确定参与者或 在12个月内影响遵守FHS-NEXT系统（n = 1500名参与者）的系统相关因素。 目标3。通过心肺运动测试检查新颖的运动能力度量的关系 （CPET）在30天内，智能手表录音的平均休息时间和每日步骤计数。 目标4。检查通过平均每周bp和平均BP的沟通法检查动脉僵硬的关系 6个月内的可变性。 我们将一个高产，多学科的团队汇集在一起​​，在应用程序开发，MHealth和 数字研究方法和分析，“大数据”整合，行为科学和CVD流行病学。我们 提议为数字和MHealth数据收集建立新的可扩展功能，并测试 传统的心血管健身和动脉神经术和新型MHealth表型的临界措施。

项目成果

Medication cost-reducing behaviors in older adults with atrial fibrillation: The SAGE-AF study.

• DOI: 10.1016/j.japh.2022.08.030
• 发表时间: 2023-01
• 期刊: JOURNAL OF THE AMERICAN PHARMACISTS ASSOCIATION
• 影响因子: 2.1
• 作者: Bamgbade, Benita A.;McManus, David D.;Briesacher, Becky A.;Lessard, Darleen;Mehawej, Jordy;Gurwitz, Jerry H.;Tisminetzky, Mayra;Mujumdar, Sarika;Wang, Weija;Malihot, Tanya;Abu, Hawa O.;Waring, Molly;Sogade, Felix;Madden, Jeanne;-Louis, Isabelle C. Pierre;Helm, Robert;Goldberg, Robert;Kramer, Arthur F.;Saczynski, Jane S.
• 通讯作者: Saczynski, Jane S.

Differences in Perceived and Predicted Bleeding Risk in Older Adults With Atrial Fibrillation: The SAGE-AF Study.

• DOI: 10.1161/jaha.120.019979
• 发表时间: 2021-09-07
• 期刊: Journal of the American Heart Association
• 影响因子: 5.4
• 作者: Bamgbade BA;McManus DD;Helm R;Mehawej J;Gurwitz JH;Mailhot T;Abu HO;Goldberg R;Wang Z;Tisminetzky M;Pierre-Louis IC;Saczynski JS
• 通讯作者: Saczynski JS

Is Catheter Ablation Associated with Preservation of Cognitive Function? An Analysis From the SAGE-AF Observational Cohort Study.

导管消融与认知功能的保留有关吗？

• DOI: 10.1101/2023.11.20.23298768
• 发表时间: 2023
• 期刊: medRxiv : the preprint server for health sciences
• 作者: Srichawla,BahadarS;Hamel,AlexanderP;Cook,Philip;Aleyadeh,Rozaleen;Lessard,Darleen;Otabil,EdithM;Mehawej,Jordy;Saczynski,JaneS;McManus,DavidD;Moonis,Majaz
• 通讯作者: Moonis,Majaz

Clinically Meaningful Change in Quality of Life and Associated Factors Among Older Patients With Atrial Fibrillation.

• DOI: 10.1161/jaha.120.016651
• 发表时间: 2020-09-15
• 期刊: Journal of the American Heart Association
• 影响因子: 5.4
• 作者: Abu HO;Saczynski JS;Mehawej J;Tisminetzky M;Kiefe CI;Goldberg RJ;McManus DD
• 通讯作者: McManus DD

Prognostic value of geriatric conditions for death and bleeding in older patients with atrial fibrillation.

老年病对老年心房颤动患者死亡和出血的预后价值。

• DOI: 10.1016/j.ijcha.2021.100739
• 发表时间: 2021-04
• 期刊: International journal of cardiology. Heart & vasculature
• 作者: Wang W;Lessard D;Saczynski JS;Goldberg RJ;Mehawej J;Gracia E;McManus DD
• 通讯作者: McManus DD