Improving Accuracy of Gene Prediction Programs of the G*

提高G*基因预测程序的准确性

• 批准号: 6686405
• 负责人: MARK BORODOVSKY
• 金额: $ 3.45万
• 依托单位: GEORGIA INSTITUTE OF TECHNOLOGY
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-12-01 至 2006-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6686405
• 关键词: Commonwealth of Independent States; computer program /software; cooperative study; genes; genetic models; genome; information dissemination; introns; mathematical model; method development; molecular biology information system; nucleic acid sequence; statistics /biometry

DESCRIPTION (provided by applicant) Generalization of the GeneMark family of gene recognition programs of gene prediction to analysis of closely related genomes using Bayesian segmentation approach. This research will be done primarily in Russia as an extension of NIH grant #5R01HG00783. The aim of this project is to build a global genomie alignment of two evolutionarily close genomes and to use a modification of the segmentation algorithm to parse syntenic regions of genome sequences. To this end the chain alignment of the extended regions of genomes will be constructed. Pairs of aligned sequences will be parsed into segments with different sequence variation statistics. A number of statistical models of genomic alignments will be built and the system, which automatically chooses the model relevant for the alignment of the particular region, will be designed. The final objective of the project is to develop a new algorithms of similarity based gene finding in the pairwise alignments of DNA sequences of closely related species. All the software programs will be available for users via the WWW interface.

描述（由申请人提供） 基因预测基因识别程序 GeneMark 系列的推广，可使用贝叶斯分割方法分析密切相关的基因组。 这项研究将主要在俄罗斯进行，作为 NIH 拨款 #5R01HG00783 的延伸。 该项目的目的是建立两个进化上接近的基因组的全局基因组比对，并使用分割算法的修改来解析基因组序列的同线区域。为此，将构建基因组延伸区域的链比对。比对的序列对将被解析为具有不同序列变异统计数据的片段。将建立许多基因组比对的统计模型，并设计自动选择与特定区域比对相关的模型的系统。该项目的最终目标是开发一种新的基于相似性的基因查找算法，用于密切相关物种 DNA 序列的成对比对。 所有的软件程序都可以通过WWW界面供用户使用。

项目成果

Short fuzzy tandem repeats in genomic sequences, identification, and possible role in regulation of gene expression.

基因组序列中的短模糊串联重复序列、鉴定以及在基因表达调控中的可能作用。

• 发表时间: 2006-03-15
• 作者: Boeva, Valentina;Regnier, Mireille;Papatsenko, Dmitri;Makeev, Vsevolod
• 通讯作者: Makeev, Vsevolod