Augmented Reality Real-Time Guidance for MRI-Guided Interventions

增强现实实时指导 MRI 引导干预

• 批准号: 10709008
• 负责人: Purnima Rajan
• 金额: $ 112.87万
• 依托单位: CLEAR GUIDE MEDICAL, INC.
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-16 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10709008
• 关键词: Adoption; Algorithms; Area; Arthrography; Artificial Intelligence; Augmented Reality; Biopsy; Bone neoplasms; Cadaver; Calibration; Caring; Child; Childhood; Clinical; Clinical Management; Companions; Computer Hardware; Computer Vision Systems; Consumption; Data; Detection; Development; Devices; Diagnosis; Doctor of Philosophy; Drainage procedure; Enrollment; Environment; Equipment; Feasibility Studies; Feedback; Goals; Hand; Head; Image; Injections; Institutional Review Boards; Intervention; Intuition; Ionizing radiation; Learning; Length; Lesion; Limb structure; MRI Scans; Magnetic Resonance Imaging; Marketing; Measures; Medical; Medical center; Modality; Monitor; Motion; Navigation System; Needle biopsy procedure; Needles; Optics; Patient Care; Patients; Pattern; Performance; Phase; Physicians; Procedures; Production; Research; Running; Scanning; Site; Skin; Small Business Innovation Research Grant; Surface; System; Tablets; Techniques; Technology; Testing; Time; Translating; Unmarried person; Validation; Visualization; Work; X-Ray Medical Imaging; accurate diagnosis; arm; bone; clinical practice; commercialization; comparison control; design; detection method; ergonomics; experience; experimental study; image guided; improved; instrument; magnetic resonance imaging biomarker; manufacturability; manufacture; painful neuropathy; patient population; pediatric patients; preference; procedure cost; prototype; radiologist; rapid diagnosis; reconstruction; safety and feasibility; soft tissue; standard of care; tool; tumor ablation; ultrasound; usability

Project Summary The objective of this proposal is to move into clinical practice the result of a preceding Phase I project, a compact instrument guidance system that allows physicians to see instruments advancing through an MRI volume without utilizing special needles, special headgear or calibration steps. MRI-guidance has been used for percutaneous needle injections to diagnose and treat neuropathic pain, perform needle biopsy, drainage, tumor ablation, and other clinical indications. In a pediatric setting, there is a preference for MR and ultrasound over CT and X-ray imaging because no ionizing radiation is emitted. Further, MR images are better for visualization of MSK soft tissue and bone lesions and would be preferred by clinicians but for the length of time to perform real-time needle insertions under MR guidance, and the poor ergonomics of in-bore insertions. Accurate and rapid diagnosis of bone tumors and other suspicious bone lesions in children is essential to appropriate clinical management. Bone biopsy procedures in children require higher targeting precision and accuracy due to their smaller sizes. MRI-guided bone biopsy is not routinely used because of current limitations in tools and technology. The “advance and check” technique whereby the needle trajectory is guided/monitored by intermediate scans has been translated from the CT environment, but this technique works well in the CT environment because of quick image acquisitions and short scanner bores. It is much more time consuming and much less convenient in the MRI environment. The overall objective of this Phase II effort is to adapt the technologies developed in the phase I to assist clinicians in accurate and fast image-guided instrument placement when using only MRI scans. The proposed navigation system for MRI-guided interventions will improve the standard of care by using computer vision and hardware advances to become a nearly hands-off companion device to the operator, automatically performing many steps which currently require user input. The LUMENA system projects the guidance feedback directly onto the intervention site as well as on a monitor. This approach allows the interventionalist to keep their focus on the insertion site instead of the monitor which is often not in front of them. The projected feedback is simple to follow and can be easily understood which makes the system intuitive with almost no learning curve. By making MRI-guided biopsies faster, the societal impact of the device is that it will allow more interventional procedures to be performed under MR-guidance, reducing ionizing radiation for patients and physicians alike.

项目概要 该提案的目的是将先前一期项目的结果付诸临床实践，即一个紧凑的 仪器引导系统，使医生能够看到仪器在 MRI 体积中前进，而无需 MRI 引导已用于经皮 针注射诊断和治疗神经性疼痛，进行针活检、引流、肿瘤消融和 在儿科环境中，MR 和超声检查优于 CT 和 X 射线检查。 因为不发射电离辐射，所以 MR 图像更适合 MSK 软件的可视化。 组织和骨骼损伤，叛军会首选，但需要进行实时针刺的时间长度 MR 引导下的插入，以及孔内插入的人体工程学较差。 准确、快速诊断儿童骨肿瘤和其他可疑骨病变对于 儿童骨活检程序需要更高的靶向精度和适当的临床管理。 由于目前的局限性，MRI 引导的骨活检并未常规使用。 工具和技术中引导/监控针轨迹的“前进和检查”技术。 通过中间扫描已从 CT 环境翻译而来，但该技术在 CT 中效果很好 由于快速的图像采集和较短的扫描仪孔径，它更加耗时且复杂。 在 MRI 环境中就不太方便了，第二阶段工作的总体目标是适应 第一阶段开发的技术有助于准确、快速的图像引导仪器 仅使用 MRI 扫描时的放置建议的 MRI 引导干预导航系统将。 通过使用计算机视觉和硬件进步来提高护理标准，成为几乎不干涉的 操作员的配套设备，自动执行当前需要用户输入的许多步骤。 LUMENA 系统将指导反馈直接投射到干预部位以及显示器上。 该方法允许介入医生将注意力集中在插入部位，而不是显示器上，而显示器通常是 预计的反馈很容易遵循并且很容易理解，这使得 系统直观，几乎没有学习曲线 通过使 MRI 引导的活检更快，可以产生社会影响。 设备的优点是它将允许在 MR 引导下进行更多的介入手术，减少电离 患者和医生的辐射。

项目成果

In situ guidance for MRI interventions using projected feedback.

使用预测反馈对 MRI 干预进行现场指导。

• 发表时间: 2023-06
• 作者: Foroughi, Pezhman;Demir, Alican;Hossbach, Martin;Rajan, Purnima;Yarmolenko, Pavel;Vellody, Ranjith;Cleary, Kevin;Sharma, Karun
• 通讯作者: Sharma, Karun