Impact of early life fluoride exposure on cognitive and behavioural outcomes in children

生命早期接触氟化物对儿童认知和行为结果的影响

• 批准号: 9352339
• 负责人: Christine Till
• 金额: $ 8.61万
• 依托单位: YORK UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-30 至 2019-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9352339
• 关键词: Address; Age; Age-Months; American; Area; Attention; Attention deficit hyperactivity disorder; Behavior; Biological; Birth; Brain; Breast Feeding; Canada; Chemicals; Child; Child Behavior; Childhood; Cities; Cognitive; Cohort Studies; Communities; Consensus; Data Quality; Decision Making; Dental; Dental caries; Dentifrices; Environmental Health; Europe; Event; Exposure to; Fetus; Fluorides; Habits; Health; Human; Individual; Infant; Infant formula; Intake; Intervention; Lead levels; Learning; Life; Low income; Measures; Municipalities; National Research Council; Outcome; Participant; Policies; Population; Pregnancy; Pregnant Women; Problem behavior; Public Health; Questionnaires; Reporting; Research; Research Project Grants; Risk; Safety; Sampling; Short-Term Memory; Source; Spottings; Standardization; System; Testing; Thyroid Function Tests; Time; Toxic effect; United States; Urine; Ursidae Family; Variant; Vulnerable Populations; Water; Water consumption; Water fluoridation; Weight; Woman; behavioral outcome; blood lead; cognitive testing; cohort; comparison group; cost effective; dosage; drinking water; environmental chemical; epidemiology study; feeding; food preparation; infancy; learning ability; population health; postnatal; prenatal; public drinking; public health intervention; public health relevance; reconstitution; risk minimization; urinary

Project Summary / Abstract Water fluoridation is a population health intervention used in Canada and the United States to control tooth decay. The safety of administering fluoride via public drinking water is uncertain. Recent human studies suggest that exposure to fluoride in drinking water may alter thyroid function, increase blood lead levels, lower IQ, and increase the risk of developing ADHD. Still, many of the human studies included groups who were exposed to higher levels of fluoride and they often lacked a comparison group or sensitive measures of behavior or learning. Given widespread exposure to fluoridated water, the US National Research Council concluded in a 2007 report that rigorous epidemiological research is urgently needed to address the controversy about the safety of this public health intervention. The aim of this study is to determine if prenatal and childhood exposure to fluoride impacts learning abilities and behavioral problems in young Canadian children, with particular emphasis on vulnerable populations. The present proposal will build upon an exceptional national pregnancy cohort study: “Maternal-Infant Research on Environmental Chemicals” (MIREC). The MIREC cohort is ideally suited to address the research objectives because the requisite information (urine during pregnancy and child outcomes) was collected in a large sample that varied as a function of municipal water fluoridation. Fluoride concentrations will be measured using stored urine samples obtained from a sample of 1960 pregnant women living in ten large Canadian cities – half of which add fluoride to municipal water. Out of 1207 participants who were approached, standardized questionnaires assessing behavioral outcomes are available for 898 children (74% of sample) living in select cities across Canada. In addition, standardized cognitive assessments, or IQ scores, are available for 610 of the children in the birth cohort. The study will also examine whether neurodevelopmental outcomes differ among children who ingested infant formula using fluoridated versus non-fluoridated water. Finally, we will examine whether serial urinary fluoride concentrations in pregnant women are higher in women who live in communities that fluoridate their municipal drinking water. The results of this study will inform public health officials and decision makers about “real-time” fluoride levels of pregnant women living in fluoridated and non-fluoridated communities. It will also provide important information about whether fluoride exposure adversely impacts children’s behaviors or learning abilities. This information will direclty impact decision making concerning the safety of water fluoridation among vulnerable populations and is therefore an area of high

项目摘要 /摘要 水氟化是加拿大和美国用于控制牙齿的人口健康干预措施 衰变。通过公共饮用水管理氟化物的安全性尚不确定。最近的人类研究 表明在饮用水中暴露于氟化物可能会改变甲状腺功能，增加血铅水平， 降低智商，并增加发展多动症的风险。尽管如此，许多人类研究包括 暴露于较高水平的氟化物，他们通常缺乏比较组或敏感测量值 行为或学习。鉴于美国国家研究委员会的宽度暴露于氟化水中 总结在2007年的一份报告中，迫切需要严格的流行病学研究来解决 关于这种公共卫生干预的安全的争议。 这项研究的目的是确定产前和儿童期暴露于氟化物是否会影响学习能力 加拿大年轻儿童的行为问题，特别着重于脆弱的人群。 本提案将基于一项杰出的国家怀孕队列研究：“产妇侵害 环境化学品研究”（MIREC）。MIREC队列非常适合解决 研究目标是因为必要的信息（怀孕期间的尿液和儿童结局）是 收集在大型样品中，该样本随着市政水氟化的函数而变化。氟化物浓度 将使用从居住在十个中的1960年孕妇样本中获得的储存的尿液样品来测量 加拿大大城市 - 其中一半在市政水中增加氟化物。在1207名参与者中 有898名儿童的接近，评估行为结果的标准化问卷 （74％的样本）居住在加拿大各地的特定城市。另外，标准化的认知评估或 智商分数可用于出生队列中的610名儿童。该研究还将检查是否 在使用氟化与使用的儿童中，神经发育结果不同 非氟化水。最后，我们将检查孕妇的系列尿液浓度是否 居住在浮动市政饮用水的社区中的妇女中，妇女的妇女更高。 这项研究的结果将为公共卫生官员和决策者提供有关“实时”氟化物的信息 居住在氟化和未氟化社区中的孕妇水平。它也将提供重要的 有关氟化物暴露是否不利影响儿童的行为或学习能力的信息。 这些信息将为有关水的氟化安全性的影响 脆弱的人群，因此是一个高的地区