Central Biochemistry Laboratory of the CKID Consortium
CKID联盟中央生化实验室
基本信息
- 批准号:10215266
- 负责人:
- 金额:$ 25.91万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2008
- 资助国家:美国
- 起止时间:2008-09-01 至 2023-07-31
- 项目状态:已结题
- 来源:
- 关键词:AddressAlbuminsAncillary StudyArchivesBicarbonatesBiochemicalBiochemistryBiological AssayBiological MarkersBloodBlood specimenCalciumCardiovascular DiseasesChildChildhoodChronic Kidney FailureClinicalCollaborationsCollectionCreatinineDataData Coordinating CenterDatabasesDry IceElectrolytesElectronic MailEquationFreezingGenerationsGlomerular Filtration RateGlucoseGoalsGrowthHairHealthHealth StatusHumanHyperuricemiaInflammationInstructionIohexolKidneyKidney Function TestsKidney TransplantationLabelLaboratoriesLipidsManualsManuscriptsMeasurementMeasuresMedicineMetabolismMicroalbuminuriaMinnesotaMonitorNail plateNephronsNeurocognitionOnline SystemsParticipantPersonsPhosphorusPlasmaPopulationProceduresProcessProductivityProspective StudiesProteinsProtocols documentationPublicationsPublishingQuality ControlReagentReproducibilityResearchResearch PersonnelRisk AssessmentRisk FactorsRoleSamplingShipsSiteSpecimenSubgroupSupervisionTelephoneTestingTimeTo specifyTrainingTransplant RecipientsTransportationTubeUnited States National Institutes of HealthUniversitiesUric AcidUrineVial deviceVisitVitamin DWorkbasecardiovascular healthcase-by-case basiscathelicidinclinical research sitecohortdata integrityimprovedinstrumentinstrumentationmeetingspost gamma-globulinspreservationrecruitrepositorysample collectionskeletalsymposiumurinary
项目摘要
The Central Biochemistry Laboratory (CBL) serves the subjects and investigators of the continuing Prospective
Study of Chronic Kidney Disease in Children (CKiD). The CBL provides participating clinical sites with
protocols, kits, reagents, supplies, and transportation required for collecting blood and urine for analysis at
URMC and other laboratories. Blood analytes include electrolytes, BUN, creatinine, glucose, calcium,
phosphorus, albumin, uric acid, lipid screen, hsCRP, intact PTH, and cystatin C. Urine analytes include
creatinine and protein. The CBL has determined optimal conditions for transporting these analytes, and
provides ambient shippers for each visit and quarterly dry ice shippers for frozen specimens. The CBL also
provides the kits and instructions for collection and shipment of blood, plasma, sera, urine, hair, and nail
samples to NIH repositories. Biochemical data from each CKiD visit are reviewed and entered into Nephron,
the CKiD data base. The CBL provides training at annual CKID meetings and is readily available to provide
information, instruction, and support during CKiD visits. The CBL contributes expertise in performing
biochemical assays and clinical interpretation of the results. The CBL collaborates regularly with the Data
Coordinating Center to provide expertise regarding laboratory medicine, optimizing GFR studies and
generating GFR estimating equations, maintaining the Manual of Procedures, assuring the quality control of all
assays, and providing continuity of biochemical assays through changes in instrumentation. The CBL
participates in all Steering Committee meetings and conference calls and collaborates with investigators in the
generation of abstracts, presentations, and manuscripts. The proposed aims of the CBL center on continuing
to provide accurate, precise, and efficient measures of biochemical measurements of general kidney health
and contribute as a scientific partner to further the research agenda of the CKiD Consortium. The CBL will
continue to provide the laboratory kits for collection, handling, and transport of samples, accurately receive,
process, and analyze these samples on a day-to-day basis, and provide timely data entry into Nephron. The
CBL has established a new subcontract with the UMN ARDL that will assure accurate measurement of iohexol
concentrations (and hence GFR) during this project period. Accordingly, the CBL will continue to develop and
optimize GFR estimating equations using conventional biomarkers in Cohort 3 subjects and other participants
with Stage 1 CKD, and in those having received a kidney transplant. The CBL has completed work on concept
sheets showing that hyperuricemia is associated with more rapid renal progression and that microalbuminuria
is no better predictor of renal progression than is urinary protein. The CBL will next examine beta trace protein
to determine if it is useful in predicting GFR. The long term goal is to better characterize the CKiD population
biochemically, maintain the integrity of the data, optimize the collection of specimens in a manner that
maintains recruitment and retention of CKiD subjects, and generate relevant publications.
中央生物化学实验室(CBL)为持续潜在的主题和研究人员服务
儿童慢性肾脏疾病的研究(CKID)。 CBL提供参与的临床站点
收集血液和尿液所需的协议,套件,试剂,供应和运输
URMC和其他实验室。血液分析物包括电解质,bun,肌酐,葡萄糖,钙,
磷,白蛋白,尿酸,脂质筛选,HSCRP,完整的PTH和胱抑素C.尿液分析物包括
肌酐和蛋白质。 CBL已确定运输这些分析物的最佳条件,并且
为每次访问提供环境托运人,并为冷冻标本提供季度干冰托运人。也是CBL
提供收集和发货的套件和说明,血浆,血清,血清,尿液,头发和指甲
样品到NIH存储库。每次CKID访问中的生化数据都会审查并输入Nephron,
CKID数据库。 CBL在年度CKID会议上提供培训,并且很容易提供
CKID访问期间的信息,指示和支持。 CBL在表演方面有助于专业知识
生化测定和结果的临床解释。 CBL定期与数据合作
协调中心以提供有关实验室医学,优化GFR研究的专业知识和
生成GFR估计方程,维护程序手册,确保所有人的质量控制
测定并通过仪器的变化提供生化测定的连续性。 CBL
参加所有指导委员会会议和电话会议,并与调查人员合作
产生摘要,演示和手稿。 CBL中心的拟议目标继续
提供准确,精确和有效的衡量一般肾脏健康的生化测量
并作为科学合作伙伴做出了贡献,以进一步发展CKID联盟的研究议程。 CBL会
继续提供用于收集,处理和运输样品的实验室套件,准确接收,
处理并每天分析这些样本,并及时地进入Nephron。这
CBL已建立了使用UMN ARDL的新分包合同,该合同将确保准确测量iohexol
在此项目期间的浓度(因此是GFR)。因此,CBL将继续发展和
使用3个受试者和其他参与者中常规生物标志物优化GFR估计方程
与第1阶段CKD一起接受肾脏移植的人。 CBL已经完成了概念的工作
表明高尿酸血症与更快的肾脏进展和微量白蛋白尿有关
与肾脏蛋白相比,肾脏进展的预测指标没有更好的预测指标。 CBL接下来检查β痕量蛋白
确定它在预测GFR中是否有用。长期目标是更好地描述CKID人群
在生化上,保持数据的完整性,以一种方式优化标本的收集方式
维持CKID主题的招聘和保留,并生成相关出版物。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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{{ truncateString('GEORGE J SCHWARTZ', 18)}}的其他基金
Bicarbonate Transport by the Maturing Renal Tubule
成熟肾小管的碳酸氢盐运输
- 批准号:
7989859 - 财政年份:2009
- 资助金额:
$ 25.91万 - 项目类别:
Central Biochemistry Laboratory of the CKiD Consortium
CKiD 联盟中央生物化学实验室
- 批准号:
7901894 - 财政年份:2009
- 资助金额:
$ 25.91万 - 项目类别:
Central Biochemistry Laboratory of the CKiD Consortium
CKiD 联盟中央生物化学实验室
- 批准号:
9323262 - 财政年份:2008
- 资助金额:
$ 25.91万 - 项目类别:
Central Biochemistry Laboratory of the CKiD Consortium
CKiD 联盟中央生物化学实验室
- 批准号:
7547815 - 财政年份:2008
- 资助金额:
$ 25.91万 - 项目类别:
Central Biochemistry Laboratory of the CKiD Consortium
CKiD 联盟中央生物化学实验室
- 批准号:
8142206 - 财政年份:2008
- 资助金额:
$ 25.91万 - 项目类别:
Central Biochemistry Laboratory of the CKID Consortium
CKID联盟中央生化实验室
- 批准号:
10454343 - 财政年份:2008
- 资助金额:
$ 25.91万 - 项目类别:
Central Biochemistry Laboratory of the CKiD Consortium
CKiD 联盟中央生物化学实验室
- 批准号:
8723158 - 财政年份:2008
- 资助金额:
$ 25.91万 - 项目类别:
Central Biochemistry Laboratory of the CKiD Consortium
CKiD 联盟中央生物化学实验室
- 批准号:
8581911 - 财政年份:2008
- 资助金额:
$ 25.91万 - 项目类别:
Central Biochemistry Laboratory of the CKiD Consortium
CKiD 联盟中央生物化学实验室
- 批准号:
8145535 - 财政年份:2008
- 资助金额:
$ 25.91万 - 项目类别:
Central Biochemistry Laboratory of the CKiD Consortium
CKiD 联盟中央生物化学实验室
- 批准号:
7681316 - 财政年份:2008
- 资助金额:
$ 25.91万 - 项目类别:
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