ShEEP Request for Acquisition of Sable Promethion Caging

ShEEP 请求收购 Sable Promethion 笼具

• 批准号: 9213046
• 负责人: CATHERINE M KOTZ
• 金额: --
• 依托单位: MINNEAPOLIS VA MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-05-01 至 2016-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9213046
• 关键词: Aging; Air; American; Animals; Area; Basic Science; Behavioral; Carbon Dioxide; Cardiovascular system; Cells; Cereals; Computer software; Control Groups; Data; Detection; Devices; Dimensions; Discipline; Doctor of Philosophy; Eating; Energy Metabolism; Environment; Equipment; Equipment and supply inventories; Event; Experimental Designs; Funding; Gases; Generations; Goals; Healthcare; Home environment; Housing; Humidity; Indirect Calorimetry; Information Systems; Intake; International; Investigational Therapies; Light; Malignant Neoplasms; Martes zibellina; Measurement; Measures; Medical; Memory; Metabolic; Minor; Modeling; Monitor; Movement; Mus; Neurosciences; Noise; Obesity; Operating System; Overweight; Physical activity; Positioning Attribute; Productivity; Program Evaluation; Rattus; Reading; Records; Reliability of Results; Reproducibility; Research; Research Design; Research Personnel; Resolution; Rodent; Running; Safety; Sampling; Secure; Services; Sleep; Solid; Stream; Stress; Surveys; System; Technology; Temperature; Testing; Translational Research; Veterans; Water consumption; Weight; abstracting; barometric pressure; base; computer program; data acquisition; equipment acquisition; gas analyzer; instrument; metabolic phenotype; metabolic rate; pressure; programs; research and development; seal; sensor; sound; stem cell therapy

Abstract: We are requesting funds through the Shared Equipment Evaluation Program (ShEEP) under the Research Equipment Management program offered by the Office of Research and Development for purchase of an 8 cage mouse and an 8 cage rat Promethion continuous cage metabolic phenotyping systems (Sable Systems, Las Vegas NV,USA) to expand upon our current Promethion mouse and rat systems. By utilizing continuous air-flow sampling, which allows for rapid metabolic measurements every second for all cages simultaneously, we are able to collect synchronous metabolic and behavioral (movement, food intake, water intake ,wheel running activity) measures. In addition, the new upgraded systems will allow for an Environmental Sensor Array to continuously monitor changes in each of the housing room's environment (temperature, noise, light, etc). The equipment will be housed within the Minneapolis VAHCS Research Services Veterinary Medical Unit. The additional systems will allow for the study of more animals simultaneously, making it possible to complete control and test paradigms more quickly, and reducing variability between control and test groups. This in turn will allow greater throughput of all users' experimental designs, increasing the productivity of the Minneapolis VAHCS investigators.The use of this equipment will compliment an existing inventory of multiuser based instruments with the end goal of increasing the efficiency of and supporting translational VA research. Dr. Catherine Kotz will oversee the administration and usage of the equipment under the full support of Minneapolis VAHCS Director, Mr. Patrick J. Kelly and the Research & Development Committee Chair, Dr. Ronald Bach. The major and minor user groups for this equipment span multiple VA research disciplines and represents both basic and translational research in areas such as: aging, cardiovascular, cancer, neuroscience, stem cell therapies and obesity. The VA funded users combined will be used at least 75% of the instrument capacity. The minor users group will occupy between 25%-30% of instrument capacity. The ability for Minneapolis VAHCS to continue to remain one of the largest and most active research programs in the VAHCS depends on the ability of its investigators to gain access to the newest generation of high-sensitivity, high-resolution instruments. The acquisition of the Promethion continuous cage metabolic phenotyping systems requested would accelerate and enhance the rate at which researchers from multiple disciplines could acquire, analyze, display, and understand data with the long-term goal of benefiting the unique health care needs of US Veterans. This not only benefits the progress of VAHCS research in general but it would benefit the health care of all Americans.

摘要：我们正在通过共享设备评估计划（绵羊）要求资金 研究与开发办公室购买的研究设备管理计划 8个笼子小鼠和8个笼大鼠求职连续笼代谢表型系统（黑貂 系统，拉斯维加斯NV，美国），以扩展我们当前的Promethion小鼠和大鼠系统。通过使用 连续气流采样，该采样允许所有笼子每秒进行快速的代谢测量 同时，我们能够收集同步代谢和行为（运动，食物，水，水 进气，车轮跑步活动）。此外，新的升级系统将允许 环境传感器阵列可连续监视每个住房室环境的变化 （温度，噪声，光等）。该设备将安置在明尼阿波利斯VAHCS研究中 服务兽医医疗部门。其他系统将允许研究更多动物 同时，可以更快地完成控制和测试范例，并减少 控制组和测试组之间的差异。反过来，这将允许所有用户的实验更大 设计，提高明尼阿波利斯VAHCS调查人员的生产率。该设备的使用将 称赞现有的基于多源工具的库存，以提高效率的最终目标 的转化VA研究和支持。凯瑟琳·科兹（Catherine Kotz）博士将监督管理和使用 在明尼阿波利斯VAHCS总监Patrick J. Kelly先生和研究的全部支持下的设备和研究 发展委员会主席罗纳德·巴赫（Ronald Bach）博士。此设备的主要用户组和次要用户组 多个VA研究学科，并代表：老化，等领域的基本和转化研究 心血管，癌症，神经科学，干细胞疗法和肥胖症。 VA资助的用户组合将是 使用仪器容量的至少75％。次要用户组将占据25％-30％ 仪器容量。明尼阿波利斯VAHC的能力继续仍然是最大，最大的人之一 VAHC中的主动研究计划取决于其研究人员获得最新访问权限的能力 产生高敏性，高分辨率仪器。收购Promethion连续笼子 所要求的代谢表型系统将加速并提高研究人员的速度 多个学科可以以长期目标获取，分析，展示和理解数据 美国退伍军人的独特医疗保健需求。这不仅有利于VAHCS研究的进步 一般，但这将使所有美国人的医疗保健受益。