Mediators of fibrosis in the development of lower urinary tract dysfunction

下尿路功能障碍发展中纤维化的介质

• 批准号: 9353662
• 负责人: WILLIAM A RICKE
• 金额: $ 120万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-09-24 至 2019-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9353662
• 关键词: Address; Automobile Driving; Basic Science; Benign; Benign Prostatic Hypertrophy; Biological; Biomedical Research; Clinical Research; Communities; Databases; Development; Fibrosis; Functional disorder; Future; Goals; Histology; Hormonal; Inflammatory; Lower urinary tract; Mediator of activation protein; Metabolic; Modeling; Molecular; Mus; National Institute of Diabetes and Digestive and Kidney Diseases; Patient Selection; Patients; Physiological; Process; Prostate; Prostatic; Prostatic Diseases; Research; Research Activity; Research Personnel; Research Project Grants; Resources; Testing; Tissues; Training; Urology; lower urinary tract symptoms; meetings; men; next generation; programs; public health relevance; targeted treatment; urinary; urologic

DESCRIPTION (provided by applicant): The Specific Aims of the UW-Madison George M. O'Brien Urology Cooperative Research Center are: 1. To investigate molecular and cellular biological mechanisms driving fibrosis in the prostates of mice and men; and 2. To investigate the relationship of hormonal, developmental, metabolic, and inflammatory processes in development of fibrosis associated with lower urinary tract dysfunction tract using functional urological testing. Fibrosis is commonly observed in the prostates of men with Benign Prostatic Hyperplasia (BPH) and Lower Urinary Tract Symptoms (LUTS). Fundamental causes of prostatic fibrosis and the relationship of prostatic fibrosis to LUTS remain unclear. The overall goals of this Center are to critically investigate fundamental mechanisms that underlie development of prostatic fibrosis and to determine the relationship between benign prostatic disease and lower urinary tract dysfunction. Our center consists of four research projects, and each incorporates unique models of benign prostatic disease in mice and analysis of tissues from BPH patients to address the objectives of the Center. The Administrative Core will provide oversight and alignment of projects. The Administrative Core will also manage the Educational Enrichment Program and Opportunity Pool. The Biomedical Research Core will provide project leaders and other investigators with the resources in mouse urinary function testing and histology to achieve the goals of the research. The Biomedical Core, in cooperation with the NIDDK and other groups, will also develop a robust database to make results and pertinent information generated by the Center and elsewhere readily accessible. This is a new venture and one that is of substantial importance to the urological research community. The long-range goal is to achieve an individualized and mechanistic understanding of LUTS pathophysiology and thereby refine patient selection for existing therapies. We will leverage our extensive institutional resources to develop an outstanding educational enrichment program that incorporates new researchers from all levels into urologic research. By meeting these objectives, this Center will make significant progress toward understanding mechanisms underlying LUTS, resulting in new mechanistically-targeted therapeutic options.

描述（由申请人提供）：UW-Madison George M. O'Brien泌尿外科合作研究中心的具体目的是：1。研究小鼠和男性前列腺中促进纤维化的分子和细胞生物学机制；和2。研究激素，发育，代谢和炎症过程在纤维化发展中与使用功能性泌尿外科测试相关的纤维化发展。在患有前列腺增生（BPH）和较低尿路症状（LUTS）的男性前列腺中通常观察到纤维化。前列腺纤维化的基本原因以及前列腺纤维化与LUT的关系尚不清楚。该中心的总体目标是批判性研究前列腺纤维化发展的基本机制，并确定良性前列腺疾病和较低的尿路功能障碍之间的关系。我们的中心由四个研究项目组成，每个研究项目都包含小鼠良性前列腺疾病的独特模型，并分析了BPH患者的组织以解决该中心的目标。行政核心将提供对项目的监督和一致性。行政核心还将管理教育丰富计划和机会池。生物医学研究核心将为项目负责人和其他研究人员提供鼠标尿功能测试和组织学中的资源，以实现研究目标。与NIDDK和其他组合作的生物医学核心也将开发一个强大的数据库，以使中心和其他地方易于访问的结果和相关信息。这是一项新事业，对泌尿外科研究界非常重要。远程目标是实现对LUTS病理生理学的个性化和机械理解，从而完善患者对现有疗法的选择。我们将利用广泛的机构资源来开发一项杰出的教育丰富计划，该计划将各级研究人员纳入泌尿外科研究。通过实现这些目标，该中心将取得重大进展，以理解LUTS的机制，从而带来新的机械性治疗选择。