Pediatric Preclinical Testing Consortium: Coordinating Center

儿科临床前检测联盟：协调中心

• 批准号: 9316556
• 负责人: GREGORY J GATTO
• 金额: $ 46.76万
• 依托单位: RESEARCH TRIANGLE INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-07-10 至 2020-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9316556
• 关键词: Address; Administrative Coordination; Bioinformatics; Biological; Cancer Etiology; Cancer Survivor; Cessation of life; Characteristics; Child; Childhood; Childhood Cancer Treatment; Clinical Trials; Collection; Community Clinical Oncology Program; Data; Data Analyses; Data Collection; Development; Dictionary; Elements; Ensure; Exhibits; Funding; General Population; Goals; Human; Leadership; Life Expectancy; Liquid substance; Logistics; Maintenance; Malignant Childhood Neoplasm; Malignant Neoplasms; Manuals; Manuscripts; Mission; Modeling; Molecular; Patients; Pediatric Oncology; Performance; Pharmaceutical Preparations; Pharmacologic Substance; Pharmacotherapy; Pre-Clinical Model; Preclinical Testing; Preparation; Procedures; Process; Program Evaluation; Quality Control; Quality of life; Radiation therapy; Recurrence; Reporting; Research; Research Personnel; Resources; Running; Scientist; Shipping; Side; Site; Specimen; Statistical Data Interpretation; System; Teleconferences; Test Result; Testing; Therapeutic Agents; Translating; advocacy organizations; cancer complication; cancer therapy; cancer type; clinical practice; data management; drug candidate; effective therapy; flexibility; innovation; meetings; member; novel therapeutics; operation; pre-clinical; premature; programs; public health relevance; quality assurance; tool; treatment effect; tumor; web page; web site; webinar

 DESCRIPTION (provided by applicant): The main goal of the Pediatric Preclinical Testing Consortium (PPTC) is to develop models that will translate to human clinical practice and effectively prioritize therapies for the treatment of pediatric cancers. An effective Coordinating Center (CC) will be critical to the Consortium's goals by providing broad organizational, scientific, and analytic expertise to support NCI scientists and the PPTC Research Programs. The CC will also be responsible for developing, implementing, and evaluating a comprehensive PPTC research program, providing leadership in data collection and ongoing program evaluation to ensure that the research program is making optimal progress toward the PPTC mission. Providing the organizational and administrative leadership necessary to enable the Consortium to function efficiently will also be a key function of the CC. RTI's goal as the proposed CC for the PPTC over the next 5 years is to optimize Consortium progress in generating reliable data to accelerate the development of more effective treatments for children with cancer by achieving the following specific aims: 1. Guide interactions between Consortium members and the pediatric oncology community at large. Provide the logistical support necessary to run an efficient and productive Consortium through effective teleconferences, webinars, Consortium meetings, and websites, both public and restricted. Employ these tools to facilitate interactions between PPTC members, pediatric clinicians, pharmaceutical companies, and pediatric oncology advocacy organizations to ensure that promising new therapies are utilized efficiently. 2. Generate reliable data that can be used for prioritization of the therapeuic agents in pediatric cancer. Provide efficient and robust procedures for data collection, statistica analysis of data collected from the Research Programs, and bioinformatic analysis of testing results that can relate treatment effects to molecular characteristics of the preclinical models utilized. 3. Provide the Consortium with a comprehensive, yet flexible set of scientific, statisticl and analytic resources needed to develop an innovative research program for creating a functional Consortium for pediatric preclinical testing. Develop tools to track the status of each potential drug candidate through the preclinical process. Document variables in a Consortium-side data dictionary as one element to build the data management system in REDCap.

 描述（由应用提供）：小儿临床前测试联盟（PPTC）的主要目标是开发将转化为人类临床实践的模型，并有效地优先考虑治疗小儿癌的治疗方法。有效的协调中心（CC）将通过提供广泛的组织，科学和分析专业知识来支持NCI科学家和PPTC研究计划，对财团的目标至关重要。 CC还将负责开发，实施和评估全面的PPTC研究计划，从而在数据收集和正在进行的计划评估方面提供领导才能，以确保研究计划在PPTC任务中取得了最佳进步。提供使财团有效运作所必需的组织和行政领导也将是CC的关键功能。在未来5年中，RTI作为PPTC提议的CC的目标是优化财团在生成可靠数据时通过实现以下具体目标来加速对癌症儿童的更有效治疗的发展：1。指导联盟成员与大部分儿科肿瘤社区之间的相互作用。通过有效的电信，网络研讨会，财团会议以及公众和限制性的网站提供必要的后勤支持，以通过有效的电信，网络研讨会，财团会议以及网站来运行高效和产品财团。使用这些工具来促进PPTC成员，儿科临床医生，制药公司和儿科肿瘤学倡导组织之间的互动，以确保有效地利用有希望的新疗法。 2。生成可靠的数据，可用于优先考虑儿科癌症治疗剂。为数据收集，从研究计划收集的数据分析以及对测试结果的生物信息学分析，提供有效且可靠的程序，这些分析可以将治疗效应与所使用的临床前模型的分子特征相关联。 3。为该财团提供一套全面但灵活的科学，统计和分析资源，以开发创新的研究计划，以创建用于儿科临床前测试的功能联盟。开发工具，通过临床前过程跟踪每个潜在药物的状态。财团端数据字典中的文档变量是在RedCap中构建数据管理系统的一个元素。